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Neurochemistry of Synaptic Renewal

  • Conference paper
Lesion-Induced Neuronal Plasticity in Sensorimotor Systems

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

  • 42 Accesses

Abstract

The renewal of synapses in the central nervous system (CNS) of mammals, particularly after traumatic deafferentation, has been studied extensively for many decades (reviewed Clemente 1964; Bernstein et al. 1978a,b; Cotman and Nadler 1978). Due to the limited regenerative capacity in the CNS of the adult mammal, it was surprising to find that morphological synaptic renewal could occur and that the new synaptic complexes were physiologically efficacious. While it is clear that the regrowth and subsequent synapse formation demonstrated in such studies is subtended by basic biochemical processes, understanding of these events is very limited. This paper will examine some of the neurochemical data which seem correlated to synaptic renewal in the CNS of adult mammals.

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Author information

Authors and Affiliations

  1. Laboratory of Nervous System Injury and Regeneration, VA Medical Center, (151Q), Washington, D.C., 20422, USA

    J. J. Bernstein & M. R. Wells

  2. Department of Neurosurgery and Physiology, George Washington University, College of Medicine, Washington, D.C., 20422, USA

    J. J. Bernstein

  3. Department of Anatomy and Embryology, Hadassah Medical School, Jerusalem, Israel

    J. J. Bernstein & D. Ganchrow

Authors
  1. J. J. Bernstein
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  2. D. Ganchrow
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  3. M. R. Wells
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Editor information

Editors and Affiliations

  1. Universität Bremen, Bibliothekstraße, 2800, Bremen 33, Germany

    Hans Flohr

  2. Institut für Hirnforschung, Universität Zürich, August-Forel-Straße 1, 8029, Zürich, Switzerland

    Wolfgang Precht

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© 1981 Springer-Verlag Berlin Heidelberg

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Bernstein, J.J., Ganchrow, D., Wells, M.R. (1981). Neurochemistry of Synaptic Renewal. In: Flohr, H., Precht, W. (eds) Lesion-Induced Neuronal Plasticity in Sensorimotor Systems. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68074-8_7

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  • DOI: https://doi.org/10.1007/978-3-642-68074-8_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68076-2

  • Online ISBN: 978-3-642-68074-8

  • eBook Packages: Springer Book Archive

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