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The Role Sprouting Might Play During the Recovery of Motor Function

  • Conference paper
Lesion-Induced Neuronal Plasticity in Sensorimotor Systems

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

A number of mechanisms have been proposed as explanations for the recovery of motor function which follows CNS lesions in adult mammals (for reviews see Goldberger 1974; Lawrence and Stein 1978). One of these is axonal (collateral) sprouting from intact fibers in response to loss of projections to a terminal field in which the damaged and the sprouting axons overlap. Sprouting in the spinal cord of new or additional terminals in a particular system might strengthen the reflex control exerted by that system (cf. Pubols and Goldberger 1980). The resulting enhancement of particular reflexes could mediate recovery of motor function if the enhanced reflexes were substituted for the reflexes lost due to the lesion. According to this scheme the movements which recover might differ in some respects from the movements lost, although their overall adaptive value might be similar to the normal movements. Furthermore, one might anticipate that, after a particular lesion, not all of the remaining reflex systems contribute equally to recovery and that not all systems will respond by sprouting to an equal extent. The system most proximate anatomically to the one damaged and whose function most nearly approximates the function initially lost might be expected to predominate.

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Authors and Affiliations

  1. Department of Anatomy, The Medical College of Pennsylvania, 3300 Henry Avenue, Philadelphia, PA, 19129, USA

    M. E. Goldberger

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  1. M. E. Goldberger
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Editors and Affiliations

  1. Universität Bremen, Bibliothekstraße, 2800, Bremen 33, Germany

    Hans Flohr

  2. Institut für Hirnforschung, Universität Zürich, August-Forel-Straße 1, 8029, Zürich, Switzerland

    Wolfgang Precht

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© 1981 Springer-Verlag Berlin Heidelberg

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Goldberger, M.E. (1981). The Role Sprouting Might Play During the Recovery of Motor Function. In: Flohr, H., Precht, W. (eds) Lesion-Induced Neuronal Plasticity in Sensorimotor Systems. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68074-8_11

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  • DOI: https://doi.org/10.1007/978-3-642-68074-8_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68076-2

  • Online ISBN: 978-3-642-68074-8

  • eBook Packages: Springer Book Archive

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