Skip to main content
  • 68 Accesses

Abstract

Alterations in haematological parameters often resulting in anaemia are among the major clinical complications encountered in patients who have had gastric surgery. The reported incidence of anaemia following partial gastrectomy has ranged from 3% to 63% [1]. Examination of the peripheral blood smear of anaemia patients after gastric surgery may be confusing, because iron-deficiency anaemia and vitamin-deficiency anaemia may coexist [2]. The reported incidence of anaemia depends on how carefully it is looked for. Although not anaemic, many more patients have low serum iron or vitamin B12 levels [3]. The incidence of anaemia increases with time. In one study, anaemia was found to be present in 9% of patients (iron-deficiency anaemia) during the first year after gastrectomy, but later 30% of the patients were found to have anaemia [4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Deller, D.J., Wilts, L.J.: Changes in the blood after partial gastrectomy with special reference to vitamin B12:I. Serum vitamin B12, hemoglobin, serum iron and bone marrow. Quart. J. Med. 31, 71 (1962)

    PubMed  CAS  Google Scholar 

  2. Lous, P., Schwartz, M.: The absorption of vitamin B12 following partial gastrectomy. Acta Med. Scand. 164, 407 (1959)

    CAS  Google Scholar 

  3. Mollin, D.L., Hines, J.D.: Observations on the nature and pathogenesis of anaemia following partial gastrectomy. Proc. Royal Soc. Med. 57, 575 (1964)

    CAS  Google Scholar 

  4. Lyngar, E.: Blood changes after partial gastrectomy for ulcer. Acta Med. Scand. (Suppl.) 1, 247 (1950)

    Google Scholar 

  5. Johnston, I.D.A.: The management of side-effects of surgery for peptic ulceration. Brit. J. Surg. 57, 787 (1970)

    Article  PubMed  CAS  Google Scholar 

  6. Baird, I.McL., Blackburn, E.K., Wilson, G.M.: The pathogenesis of anemia after partial gastrectomy: 1) Development of anemia in relation to time after partial gastrectomy: operation, blood loss, and diet. Quart. J. Med. 28, 21 (1959)

    PubMed  CAS  Google Scholar 

  7. Baird, I.McL., Wilson, G.M.: The pathogenesis of anemia after partial gastrectomy. 2. Iron absorption after partial gastrectomy. Quart. J. Med. 28, 35 (1959)

    PubMed  CAS  Google Scholar 

  8. Baird, I.McL., St. John, D.J.B., Nasser, S.S.: Role of occult blood loss in anemia after partial gastrectomy. Gut 11, 55 (1970)

    Article  PubMed  CAS  Google Scholar 

  9. Mahmud, K., Ripley, D., Doscherholmen, A.: Vitamin B12 absorption tests, their unreliability in postgastrectomy states. J.A.M.A. 216, 1167 (1971)

    Article  PubMed  CAS  Google Scholar 

  10. Mahmud, K., Ripley, D., Swaim, W.R., Doscherholmen, A.: Hematologic complications of partial gastrectomy. Ann. Surg. 177, 432 (1973)

    Article  PubMed  CAS  Google Scholar 

  11. Hines, J.D., Hoffbrand, A.V., Mollin, D.L.: The haematological complications of a partial gastrectomy. Am. J. Med. 43, 555 (1967)

    Article  PubMed  CAS  Google Scholar 

  12. Pryor, J.P., O’Shea, M.J., Brooks, P.L., Datar, G.K.: The long-term metabolic consequences of partial gastrectomy. Am. J. Med. 51, 5 (1971)

    Article  PubMed  CAS  Google Scholar 

  13. Hobbs, J.R.: Iron deficiency anemia after partial gastrectomy. Gut 2, 141 (1961)

    Article  PubMed  CAS  Google Scholar 

  14. Kimber, C., Patterson, J.F., Weintraub, C.R.: The pathogenesis of iron deficiency anemia following partial gastrectomy. J. Am. med. Assoc. 202, 935 (1967)

    Article  CAS  Google Scholar 

  15. Holt, J.M., Mayet, F.G.H., Warner, G.T. et al.: Iron absorption and blood loss in patients with hiatus hernia. Brit. Med. J. 3, 22 (1968)

    Article  PubMed  CAS  Google Scholar 

  16. Holt, J.M., Gear, M.W.L., Warner, G.T.: The role of chronic blood loss in the pathogenesis of post-gastrectomy iron-deficiency anemia. Gut 11, 847 (1970)

    Article  PubMed  CAS  Google Scholar 

  17. MacGregor, I.L., Parent, J., Meyer, J.H.: Gastric emptying of liquid meals and pancreatic and biliary secretions after subtotal gastrectomy or truncal vagotomy and pyloroplasty in man. Gastroenterology 72, 195 (1977)

    PubMed  CAS  Google Scholar 

  18. MacLean, L.D.: Incidence of megaloblastic anemia after subtotal gastrectomy. New Engl. J. Med. 257, 262 (1957)

    CAS  Google Scholar 

  19. Jones, C.T., Williams, J.A., Cox, F.V. et al.: Peptic ulceration. Some hematological and metabolic consequences of gastric surgery. Lancet II, 425 (1962)

    Article  Google Scholar 

  20. Weir, D.G., Gatenby, P.B.B.: Anaemia following gastric operations for peptic ulceration in Dublin. Brit. J. Med. Science 447, 105 (1963)

    CAS  Google Scholar 

  21. Weir, D.G., Gatenby, P.B.B.: Subacute combined degeneration of the cord after partial gastrectomy. Brit. Med. J. 2, 1175 (1963)

    Article  PubMed  CAS  Google Scholar 

  22. Hall, C.A.: Importance of red cell B12 and folate levels after partial gastrectomy. Am. J. Clin. Nutr. 27, 899 (1974)

    PubMed  CAS  Google Scholar 

  23. Rygvold, O.: Hypovitaminosis B12 following partial gastrectomy by the Billroth II method. Scand. J. Gastroent. (Suppl. 9 ) 29, 57 (1974)

    Google Scholar 

  24. Loewenstein, F.: Absorption of cobalt (Co) labeled vitamin B12 after subtotal gastrectomy. Blood 13, 339 (1958)

    PubMed  CAS  Google Scholar 

  25. Doscherholmen, A., Swaim, W.R.: Impaired assimilation of CO57 vitamin B12 in patients with hypochlorhydria and achlorhydria after gastric resection. Gastroenterology 64, 913 (1973)

    PubMed  CAS  Google Scholar 

  26. Streeter, A.M., Balasubramaniam, D., Boyle, R., et al.: Malabsorption of vitamin B12 after vagotomy. Am. J. Surgery 128, 340 (1974)

    Article  CAS  Google Scholar 

  27. Toskes, P.P., Deren, J.J.: Vitamin B12 absorption and malabsorption. Gastroenterology 65, 662 (1973)

    PubMed  CAS  Google Scholar 

  28. Wheldon, E.J., Venables, C.W., Johnston, I.D.A.: Late metabolic sequela of vagotomy and gastroenterostomy. Lancet I, 437 (1970)

    Google Scholar 

  29. Schjonsky, H.: The absorption of vitamin B12 in the blind loop syndrome. Scand. J. Gastroenterol. 29, 65 (1974)

    Google Scholar 

  30. Brandt, L.J., Bernstein, L.H., Wagle, A.: Production of vitamin B12 analogues in patients with small-bowel bacterial overgrowth. Ann. int. Med. 87, 546 (1977)

    PubMed  CAS  Google Scholar 

  31. Deller, D.J., Ibbotson, R.N., Crompton, B.: Metabolic effects of partial gastrectomy with special reference to calcium and folic acid: Part II. The contribution of folic acid deficiency to the anemia. Gut 5, 225 (1964)

    Article  PubMed  CAS  Google Scholar 

  32. Wastell, C.: Malabsorptive states after gastrointestinal surgery. Brit. Med. J. 3, 661 (1968)

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Becker, H.D., Caspary, W.F. (1980). Postgastrectomy Anaemia. In: Postgastrectomy and Postvagotomy Syndromes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67350-4_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67350-4_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67352-8

  • Online ISBN: 978-3-642-67350-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics