Skip to main content
SpringerLink
Log in

Primary Hyperoxaluria and Related Conditions

  • Chapter
Renal Calculus

  • 218 Accesses

Abstract

Primary hyperoxaluria is the name at present given to a genetically determined disorder of oxalate metabolism, the clinical manifestations of which are recurrent calcium oxalate nephrolithiasis and later in the disease radiologically demonstrable nephro-calcinosis, with a continuously high output of oxalic acid and usually of glycollic acid and glyoxylic acid in the urine and progressive renal damage leading to death in uraemia. At autopsy, though not demonstrable clinically, extrarenal crystalline deposits of calcium oxalate are found in many organs as well as in the kidney, the syndrome then being called ‘oxalosis’.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Admirand,W.H., Earnest,D., Williams,H.: Hyperoxaluria and bowel disease. Clin. Res. 19, 562 (Abstr.) (1971)

    Google Scholar 

  2. Allen,A.C.: The kidney: medical and surgical disease. London: Churchill 1952

    Google Scholar 

  3. Andrus,S.B., Gershoff,S.N., Faragalla,F.F., Prien,E.L.: Production of calcium oxalate renal calculi in vitamin B6 deficient rats. Lab. Invest. 9, 7 (1960)

    PubMed  CAS  Google Scholar 

  4. Antoine,B., Slama,R., Josso,F., Montera,H. de, Habib,R., Richet,G.: The destruction of renal parenchyma by invasion by calcium oxalate crystals. Two new cases of ‘renal oxalosis’. Presse Med. 68, 803 (1960)

    PubMed  CAS  Google Scholar 

  5. Aponte,G.E., Fetter,T.B.: Familial idiopathic oxalate nephrocalcinosis. Am. J. Clin. Pathol. 24, 1363 (1954)

    PubMed  CAS  Google Scholar 

  6. Archer,H.E., Dormer,A.E., Scowen,E.F., Watts,R.W.E.: Primary hyperoxaluria. Lancet II, 320 (1957a)

    Article  Google Scholar 

  7. Archer,H.E., Dormer,A.E., Scowen,E.F., Watts,R.W.E.: Studies on the urinary excretion of oxalate by normal subjects. Clin. Sci. 16, 405 (1957b)

    PubMed  CAS  Google Scholar 

  8. Archer,H.E., Dormer,A.E., Scowen,E.F., Watts,R.W.E.: The etiology of primary hyperoxaluria. Br. Med. J. 1, 175 (1958)

    Article  PubMed  CAS  Google Scholar 

  9. Berman,L.B., Schiemer,G.E., Feys,J.: The nephrotoxic lesion of ethylene glycol. Ann. Int. Med. 46, 611 (1962)

    Google Scholar 

  10. Bourke,E., Frindt,G., Flynn,P., Schreiner,G.E.: Primary hyperoxaluria with normal alpha-ketoglutarate: glyoxylate carboligase activity. Ann. Int. Med. 76, 279 (1972)

    PubMed  CAS  Google Scholar 

  11. Chadwick,V.S., Modha,K., Dowling,R.H.: Mechanism for hyperoxaluria in patients with ileal dysfunction. N. Engl. J. Med. 289, 172 (1973)

    Article  PubMed  CAS  Google Scholar 

  12. Chikos,P.M., McDonald,G.B.: Regional enteritis complicated by nephrocalcinosis and nephrolithiasis. Case report. Radiology 121, 75 (1976)

    CAS  Google Scholar 

  13. Chisholm,G.D., Heard,E.G.: Oxalosis. Br. J. Surg. 50, 78 (1962)

    Article  PubMed  CAS  Google Scholar 

  14. Chou,L.Y., Donohue,W.L.: Oxalosis: possible ‘inborn error of metabolism’ with nephrolithiasis and nephrocalcinosis due to calcium oxalate as the predominating features. Pediatrics 10, 660 (1952)

    PubMed  CAS  Google Scholar 

  15. Cochran,M., Hodgkinson,A., Zarembski,P.M.: Hyperoxaluria in adults. Br. J. Surg. 55, 121 (1968)

    Article  PubMed  CAS  Google Scholar 

  16. Cusworth,D.C., Dent,C.E.: Renal clearance in normal subjects and in patients with aminoaciduria. Biochem. J. 74, 550 (1960)

    PubMed  CAS  Google Scholar 

  17. Daniels,R.A., Michels,R., Aisen,P., Gold-stein,G.: Familial hyperoxaluria: report of a family, review of the literature. Am. J. Med. 29, 820 (1960)

    Article  PubMed  CAS  Google Scholar 

  18. Davis,J.S., Klineberg,W.G., Stowell,R.E.: Nephrolithiasis and nephrocalcinosis with calcium oxalate crystals in kidneys and bones. J. Pediat. 36, 323 (1950)

    Article  PubMed  CAS  Google Scholar 

  19. Dempsey,E.F., Forbes,A.P., Melick,R.A., Henneman,P.H.: Urinary oxalate excretion. Metabolism 9, 52 (1960)

    PubMed  CAS  Google Scholar 

  20. Dent,C.E., Friedman,M.: Hypophospha-turic osteomalacia with complete recovery. Br. Med. J. I, 1676 (1964)

    Google Scholar 

  21. Dent,C.E., Stamp,T.C.B.: Treatment of primary hyperoxaluria. Arch. Dis. Child. 45, 244 (1970)

    Article  Google Scholar 

  22. Deodhar,S.D., Tung,K.S.K., Zuhlke,V., Nakatoto,S.: Renal transplantation in a patient with primary familial oxalosis. Arch. Pathol. 87, 118 (1969)

    PubMed  CAS  Google Scholar 

  23. Derot,M., Legrain,M., Prunier,P., Quenu,L.: Two cases of familial oxalosis in adults. J. Urol. Nephrol. 68, 589 (1962)

    CAS  Google Scholar 

  24. Desgrez,P., Thomas,J., Thomas,E., Rabus-sier,P.: Facteurs influençant l’équilibre urinaire dans la lithiase calcique. Rein Foie 4, 189 (1962)

    Google Scholar 

  25. De Toni,G., Durand,P., Rosso,C.: L’asslosi una nuova malattia del ricambio a carattere tessurismico. Minerva Pediatr. 2, 623 (1967)

    Google Scholar 

  26. De Vries,A., Kochwa,S., Lazebnick,J.: Glycinuria, hereditary disorder associated with nephrolithiasis. Am. J. Med. 23, 408 (1957)

    Article  Google Scholar 

  27. Dowling,R.H., Rose,G.A., Sutor,J.S.: Hyperoxaluria and renal calculi in ileal disease. Lancet I, 1103 (1971)

    Article  Google Scholar 

  28. Dunn,H.G.: Oxalosis. Am. J. Dis. Child. 90, 58 (1955)

    CAS  Google Scholar 

  29. Dunn,H.G., Haworth,A., Jones,N.A.: The pathology of oxalate nephritis. J. Pathol. Bacteriol. 27, 299 (1924)

    Article  CAS  Google Scholar 

  30. Elder,T.D., Wyngaarden,J.B.: The biosynthesis and turnover of oxalate in normal and hyperoxaluric subjects. J. Clin. Invest. 39, 1337 (1960)

    Article  PubMed  CAS  Google Scholar 

  31. Faber,S.R., Feitler,W.W, Bleüer,R.E, Ohlson,M.A., Hodges,R.E.: The effects of an induced pyridoxine and pentothenic acid deficiency on excretion of oxalic and xanthurenic acids in the urine. Am. J. Clin. Nutr. 12, 406 (1963)

    Google Scholar 

  32. Frederick,E.W., Rabkin,M.T., Ritchie,R.H Jr., Smith,L.E Jr.: Studies on primary hyperoxaluria. I. In vivo demonstrations of a defect in glyoxylate metabolism. N. Engl. J. Med. 269, 821 (1963)

    Article  PubMed  CAS  Google Scholar 

  33. Friedman,E.A., Greenberg,J.B., Merrill,J.P., Dammin,G.J.: Consequences of ethylene glycol poisoning. Am. J. Med. 32, 811 (1962)

    Article  Google Scholar 

  34. Gerritsen,T., Kaveggia,E., Waisman,H.A.: A new type of idiopathic hyperglycinemia with hypo-oxaluria. Pediatrics 36, 882 (1965)

    PubMed  CAS  Google Scholar 

  35. Gershoff,S.N., Andrus,S.B.: Effect of vitamin B6 and magnesium on renal deposition of calcium oxalate induced by ethylene glycol administration. Proc. Soc. Exp. Biol. Med. 109, 99 (1962)

    PubMed  CAS  Google Scholar 

  36. Gershoff,S.N., Faragalla,F.F.: Endogenous oxalate synthesis and glycine, serine, desoxypyridoxine interrelationships in vitamin B6 deficient rats. J. Biol. Chem. 234, 239 (1959)

    Google Scholar 

  37. Gershoff,S.N., Prien,E.L.: Excretion of urinary metabolites in calcium oxalate urolithiasis. Effect of tryptophan and vitamin B6 administration. Am. J. Clin. Nutr. 8, 812 (1960)

    PubMed  CAS  Google Scholar 

  38. Gershoff,S.N., Faragalla,F.F., Nelson,D.A., Andrus,S.B.: Vitamin B6 deficiency and oxalate nephrocalcinosis in the cat. Am. J. Med. 27, 72 (1959)

    Google Scholar 

  39. Gibbs,A., Watts,R.W.E.: Biochemical studies on treatment of primary hyperoxaluria. Arch. Dis. Child. 42, 505 (1967)

    Article  PubMed  CAS  Google Scholar 

  40. Giertz,G.: Hyperoxaluria. Urologists’ Correspondents Club 2nd Jan. 1970

    Google Scholar 

  41. Godwin,J.T., Fowler,M.R., Dempsey,E.F., Henneman,P.H.: Primary hyperoxaluria and oxalosis; Report of a case and review of the literature. N. Engl. J. Med. 259, 1099 (1958)

    Article  PubMed  CAS  Google Scholar 

  42. Hall,E.G., Scowen,E.F, Watts,R.W.E.: Clinical manifestations of primary hyperoxaluria. Arch. Dis. Child. 35, 108 (1960)

    Article  PubMed  CAS  Google Scholar 

  43. Harrison,A.R.: Urinary calculi in bowel disorders. In: Scientific foundations of urology. Williams,D.I., Chisholm,G.D. (eds.), Vol. I, p. 315. Heinemann: London 1976

    Google Scholar 

  44. Hockaday,T.D.R., Clayton,J.E., Frederick,E.W., Smith,L.H Jr.: Primary hyperoxaluria. Medicine 43, 315 (1964)

    PubMed  CAS  Google Scholar 

  45. Hockaday,T.D.R., Frederick,E.W., Clay-ton,J.E., Smith,L.H. Jr.: Studies on primary hyperoxaluria. II. Urinary oxalate, glycol-ate and glyoxylate measurement by isotope dilution methods. J. Lab. Clin. Med. 65, 677 (1965)

    PubMed  CAS  Google Scholar 

  46. Hodgkinson,A.: The urinary excretion of oxalic acid in nephrolithiasis. Proc. R. Soc. Med. 51,970 (1958)

    PubMed  CAS  Google Scholar 

  47. Hodgkinson,A.: Oxalate metabolism and hyperoxaluria. In: Scientific foundations of urology. Williams,D.L, Chisholm,G.D. (eds.), Vol. I, p. 289. Heinemann: London 1976

    Google Scholar 

  48. Hofmann,A.F., Thomas,P.J., Smith,L.H., McCall,J.T.: Pathogenesis of secondary hyperoxaluria in patients with ileal resection. Gastroenterology 58, 960 (1970)

    Google Scholar 

  49. Klauwers,J., Wolf,P.L., Cohn,R.: Failure of renal transplantation in primary oxalosis. J. Am. Med. Assoc. 209, 551 (1969)

    Article  CAS  Google Scholar 

  50. Koch,J., Stokstad,E.L.R., Williams,H.E., Smith,L.H. Jr.: Deficiency of 2-oxo-glu-tarate, glyoxylate carboligase activity in primary hyperoxaluria. Proc. Natl. Acad. Sci. USA. 57, 1123 (1967)

    Article  PubMed  CAS  Google Scholar 

  51. Koten,J.W., Gastel,C. van, Mees,E.J.: Two cases of primary oxalosis. J. Clin. Pathol. 18, 223 (1965)

    Article  PubMed  CAS  Google Scholar 

  52. Lagrue,G., Laudat,M.H., Meyer,P., Sapil,M., Milliez,P.: Oxalose familiale avec acidose hyperchloremique secondaire. Semaine Hopital de Paris 35, 2023 (1959)

    CAS  Google Scholar 

  53. Largiader,F., Zollinger,H. U.: Oxalosis. Part I. Empirical studies. Virchows Arch. 333, 368 (1960)

    Article  CAS  Google Scholar 

  54. Lapoutre,C.: Calculs multiples chez un enfant: infiltration du parenchyme renal par des depots cristallins. J. Urol. 20,424 (1925)

    Google Scholar 

  55. Ludwig,G.D.: Renal calculi associated with hyperoxaluria. Ann. N.Y. Acad. Sci. 104, 621 (1963)

    Article  PubMed  CAS  Google Scholar 

  56. Lund,T., Reske-Nielsen,E.: Nephrolithiasis and nephrocalcinosis with calcium oxalate crystals in the kidneys and other organs. Report on two cases. Acta Pathol. Microbiol. Scand. 38, 353 (1956)

    Article  PubMed  CAS  Google Scholar 

  57. Lyon,E.S., Borden,T.A., Ellis,J.E., Ver-meulen,C.W.: Calcium oxalate lithiasis produced by pyridoxine deficiency and inhibition with high magnesium diets. Invest. Urol. 4, 133 (1966)

    PubMed  CAS  Google Scholar 

  58. Marshall,V.F., Horwith,M.: Oxalosis. J. Urol. 82, 278 (1959)

    CAS  Google Scholar 

  59. Mazze,R.I. et al.: Methoxyflurane anaesthesia. Arch. Pathol. 92, 484 (1971)

    PubMed  CAS  Google Scholar 

  60. McLaurin,A.W., Beisel,W.R., McCormick,G.J., Scaletter,R., Herman,R.H.: Primary hyperoxaluria. Ann. Int. Med. 55, 70 (1961)

    PubMed  CAS  Google Scholar 

  61. Melon,J.M. et al: Experimental oxalic lithiasis induced with ethylene glycol in rats. Its value in trial hypoxaluria treatment. Therapie 26, 991 (1971)

    PubMed  CAS  Google Scholar 

  62. Milne,M.D.: Oxalosis in an adult. Br. Med. J. II, 637 (1961)

    Google Scholar 

  63. Modlin,M.: Hyperoxaluria urinary calculi and ulcerative colitis. Br. Med. J. III, 292 (1972)

    Article  Google Scholar 

  64. Newnes,G.H., Black,J.A.: Calcium oxalate nephrocalcinosis. Gt. Ormond St. J. 5, 40 (1953)

    Google Scholar 

  65. Nyhan, W.L.: Non-ketoic hyperglycinemia. In: The metabolic basis of inherited disease Stanbury,J.B., WyngaardenJ.B., Fredrick-son,D.G. (eds.). 3rd ed. New York: McGraw-Hill 1972

    Google Scholar 

  66. Olgaard,H., Soderkjelm,L.: Familial oxalosis. Acta Soc. Med. Upsal. 62, 176 (1957)

    Google Scholar 

  67. Paddock,R.B., Parker,J.W., Guadagni,N.P.: The effects of methoxyflurane on renal function. Anesthesiology 25, 707 (1964)

    Article  PubMed  CAS  Google Scholar 

  68. Pons,C.A., Custer,R.P.: Acute ethylene glycol poisoning: clinicopathologic report of 18 fatal cases. Am. J. Med. Sci. 211, 544 (1946)

    PubMed  CAS  Google Scholar 

  69. Prien,E.L., Gershoff,S.N.: Newton-Welles-ley Med. Bull. 18, 28 (1966)

    Google Scholar 

  70. Pyrah,L.N., Anderson,C.K., Hodgkinson,A., Zarembski,P.M.: A case of oxalate nephrocalcinosis and primary hyperoxaluria. Br. J. Urol. 31, 235 (1959)

    Article  PubMed  CAS  Google Scholar 

  71. Scowen,E.F., Stansfield,A.G., Watts,R.W.E.: Oxalosis and primary hyperoxaluria. J. Pathol. Bacteriol. 77, 195 (1959)

    Article  PubMed  CAS  Google Scholar 

  72. Silver,L., Brendler,H.: The use of magnesium oxide in the management of familial hyperoxaluria. J. Urol. 106, 274 (1971)

    PubMed  CAS  Google Scholar 

  73. Smith,L.H. Jr., Williams,H.E.: Treatment of primary hyperoxaluria. Mod. Treat. 4, 522 (1969)

    Google Scholar 

  74. Solomons,C.C., Goodman,S.L, Riley,C.M.: Calcium carbimide in the treatment of primary hyperoxaluria. N. Engl. J Med. 276, 207 (1964)

    Article  Google Scholar 

  75. Swartz,D., Israels,S.: Primary hyperoxaluria. J. Urol. 90, 94 (1963)

    PubMed  CAS  Google Scholar 

  76. Vermeulen,C.W., Grove,W.J., Goetz,R., Raggins,H.D., Carroll,N.O.: Experimental lithiasis. I. Development of calculi upon foreign bodies introduced into the bladders of rats. J. Urol. 64, 541 (1950)

    PubMed  CAS  Google Scholar 

  77. Vermeulen,C.W., Lyon,E.S., Gill,W.B., Chapman,W.H.: Prevention of phosphate stones by phytate, phosphate and hexa-metaphosphate: experimental urolithiasis. J. Urol. 82, 249 (1959)

    PubMed  CAS  Google Scholar 

  78. Walls,J., Morley,A.R., Kerr,D.N.: Primary hyperoxaluria in adult siblings: with some observations on the role of regular haemo-dialysis therapy. Br. J. Urol. 41, 546 (1969)

    Article  PubMed  CAS  Google Scholar 

  79. Watts,R.W.E., Crawhall,J.C.: The first glycine metabolic pool in man. Biochem. J. 73, 277 (1959)

    PubMed  CAS  Google Scholar 

  80. Williams,H.E., Smith,L.H Jr.: Disorders of oxalate metabolism. Am. J. Med. 45, 713 (1968a)

    Article  Google Scholar 

  81. Williams,H.E., Smith,L.H. Jr.: L-glyceric aciduria: a new genetic variant of primary hyperoxaluria. N. Eng. J. Med. 278, 233 (1968b)

    Article  CAS  Google Scholar 

  82. Williams,H.E., Smith,L.H.: L-glyceric aciduria. In: Renal Stone Research Symposium. Hodgkinson, A., Nordin, B.E.C. (eds.), p. 309. London: Churchill 1969

    Google Scholar 

  83. Wyngaarden,J.B., Elder,T.D.: Primary hyperoxaluria and oxalosis. In: The metabolic basis of inherited disease Stanbury,J.B., Wyngaarden,J., Fredrickson,D.S. (eds.). New York: McGraw-Hill 1966

    Google Scholar 

  84. Zarembski,P.M., Hodgkinson,A.: The renal clearance of oxalic acid in normal subjects and in patients with primary hyperoxaluria. Invest. Urol. 1, 87 (1963)

    PubMed  CAS  Google Scholar 

  85. Zarembski,P.M., Hodgkinson,A., Cochran,M.: Treatment of primary hyperoxaluria with calcium carbimide. N. Engl. J. Med. 277, 1000 (1967)

    Article  PubMed  CAS  Google Scholar 

  86. Zarembski,P.M., Hodgkinson,A., Cochran,M.: Urinary excretion of lactic acid and other organic acids in patients with primary hyperoxaluria. In: Renal Stone Research Symposium. Hodgkinson,A., Nordin,B.E.C. (eds.), p. 319. London: Churchill 1969

    Google Scholar 

  87. Zollinger,H.U., Rosenmund,H.: Uramie bei androgen bedingter subakuter und chronischen Calciumoxalatniere (calciumoxala-tnephritis und calcium oxalatsehrump-fniere). Schweiz. Med. Wochnschr. 82, 1261 (1952)

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Leeds, UK

    Dr. Leslie N. Pyrah (Emeritus Professor of Urological Surgery, Past President of the British Association of Urological Surgeons)

  2. 55 Weetwood Lane, Leeds, LS16 5NP, Great Britain

    Dr. Leslie N. Pyrah (Emeritus Professor of Urological Surgery, Past President of the British Association of Urological Surgeons)

Authors
  1. Dr. Leslie N. Pyrah
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Pyrah, L.N. (1979). Primary Hyperoxaluria and Related Conditions. In: Renal Calculus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67124-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67124-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67126-5

  • Online ISBN: 978-3-642-67124-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation