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Absorption, Distribution, and Excretion of Antineoplastic and Immunosuppressive Agents

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Antineoplastic and Immunosuppressive Agents Part I

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Abstract

The general principles of pharmacological disposition apply almost universally to compounds which are foreign to the mammalian organism, including antineoplastic and immunosuppressive agents. Thus, the interrelated mechanisms of absorption, binding, distribution, metabolism, and excretion are the chief factors that determine the effective concentration of a drug at a receptor site (Fig. 1). In this chapter, a brief consideration is given to those processes which regulate the response of an organism to several commonly used antineoplastic and immunosuppressive agents. Excluded is the more complex process of metabolism since this aspect of pharmacological disposition is considered in two later chapters, and also in the chapters dealing with individual agents.

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Authors
  1. Vincent T. Oliverio
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Istitutes of Health, Bethesda, Maryland, 20014, USA

    David G. Johns M. D.

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© 1974 Springer-Verlag Berlin · Heidelberg

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Oliverio, V.T. (1974). Absorption, Distribution, and Excretion of Antineoplastic and Immunosuppressive Agents. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents Part I. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65678-1_12

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  • DOI: https://doi.org/10.1007/978-3-642-65678-1_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65680-4

  • Online ISBN: 978-3-642-65678-1

  • eBook Packages: Springer Book Archive

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