Abstract
Studies on the thymus have revealed differences in its control of the development of immunological responsiveness in different species [1]. In the chicken, cellmediated immune responses have been demonstrated to be thymus-dependent but humoral antibody responses have been found to be affected by a different lymphoid organ, the bursa of Fabricius [2]. It has been argued that a similar system might operate in mammals [3, 4] but investigations in the mouse have so far failed to reveal unequivocal evidence of a dichotomy in the development of immunological responsiveness. Studying the responses to a wide variety of antigens, varying from skin homografts and oxazolone to serum proteins and bacterial antigens, in normal, thymus-deprived and thymus-reconstituted CBA mice, it has been show that all, with the possible exception of pneumococcal polysaccharide, are thymus dependent. This finding will be considered in relation to the numbers of residual thymusderived cells in deprived mice [5]. The significance of the demonstrated spectrum of thymus dependency in mice and its relation to the “bursal equivalent” theory will be discussed.
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Leuchars, E. (1971). The Spectrum of Thymus Dependency. In: Dumonde, D.C. (eds) The Role of Lymphocytes and Macrophages in the Immunological Response. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65133-5_1
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DOI: https://doi.org/10.1007/978-3-642-65133-5_1
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