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Antibody-like Receptors on Immunocompetent Cells

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Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 54))

Abstract

It is probably not an exaggeration to say that one of the central problems of immunology is: how does a cell recognize an antigen when it sees one? Burnet was probably the first to recognize clearly the importance of the recognition problem and also the first to attempt to offer a solution (Burnet and Fenner, 1949). His original indirect template theory, based on so-called recognition units for self-markers, was too much of an exercise in imagination to gain wide acceptance. When he advanced his next theory, the “clonal selection theory” (Burnet, 1959), it naturally encountered strong opposition by the chemically oriented, and by then firmly entrenched, instructive theories. However, as immunology progressed at an ever increasing rate, more and more facts accumulated, which could be best explained in terms of clonal selection. The word “receptor” began to appear in the literature.

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References

  • Abdou, N. I., Richter, M.: Cells involved in the immune response. VI. The immune response to red blood cells in irradiated rabbits after administration of normal, primed, or immune allogeneic rabbit bone marrow cells. J. exp. Med. 129, 757–774 (1969a).

    Article  PubMed  CAS  Google Scholar 

  • Abdou, N. I., Richter, M.: Cells involved in the immune response. X. The transfer of antibody-forming capacity to irradiated rabbits by antigen-reactive cells isolated from normal allogeneic rabbit bone marrow after passage through antigen-sensitized glass bead columns. J. exp. Med. 130, 141–163 (1969b).

    Article  PubMed  CAS  Google Scholar 

  • Abdou, N. I., Richter, M.: Cells involved in the immune response. XL Identification of the antigen-reactive cell as the tolerant cell in the immunologically tolerant rabbit. J. exp. Med. 130, 165–184 (1969 c).

    Article  PubMed  CAS  Google Scholar 

  • Ada, G. L., Byrt, P.: Specific inactivation of antigen-reactive cells with 125I-labelled antigen. Nature (Lond.) 222, 1291–1292 (1969).

    Article  CAS  Google Scholar 

  • Adler, F. L.: Competition of antigens. Progr. Allergy 8, 41–57 (1964).

    CAS  Google Scholar 

  • Adler, F. L., Fishman, M., Dray, S.: Antibody formation initiated in vitro. III. Antibody formation and allotypic specificity directed by ribonucleic acid from peritoneal exudate cells. J. Immunol. 97, 554–558 (1966).

    PubMed  CAS  Google Scholar 

  • Argyris, B. F.: Role of thymus in adoptive tolerance. J. Immunol. 100, 1255–1258 (1968).

    PubMed  CAS  Google Scholar 

  • Armstrong, W. D., Diener, E., Shellam, G. R.: Antigen-reactive cells in normal, immunized, and tolerant mice. J. exp. Med. 129, 393–410 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Biozzi, G., Stiefel, C., Mouton, D., Bouthillier, Y., Decreusefond, C.: A kinetic study of antibody producing cells in the spleen of mice immunized intravenously with sheep erythrocytes. Immunology 14, 7–20 (1968).

    PubMed  CAS  Google Scholar 

  • Birnbaum, M., Sulitzeanu, D.: Immunological paralysis of sensitized cells, induced in vitro. Immunology 17, 635–637 (1969).

    PubMed  CAS  Google Scholar 

  • Bretscher, P. A., Cohn, M.: Minimal model for the mechanism of antibody induction and paralysis by antigen. Nature (Lond.) 220, 444–448 (1968).

    Article  CAS  Google Scholar 

  • Britton, S.: Regulation of antibody synthesis against Escherichia coli endotoxin. IV. Induction of paralysis in vitro by treating normal lymphoid cells with antigen. J. exp. Med. 129, 469–481 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Burnet, F. M., Fenner, F.: Production of antibodies, 2nd ed. Melbourne: Macmillan 1949.

    Google Scholar 

  • Burnet, M.: The clonal selection theory of acquired immunity. Cambridge: University Press 1959.

    Google Scholar 

  • Byers, V. S., Sercarz, E. E.: The X-Y-Z scheme of immunocyte maturation. V. Paralysis of memory cells. J. exp. Med. 128, 715–728 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Byrt, P., Ada, G. L.: An in vitro reaction between labelled flageUin or haemocyanin and lymphocyte-like cells from normal animals. Immunology 17, 503–516 (1969).

    PubMed  CAS  Google Scholar 

  • Cross, A. M., Mäkelä, O.: Selective inhibition of the secondary response of primed cells by incubation with hapten. Immunology 15, 389–394 (1968).

    PubMed  CAS  Google Scholar 

  • Daguillard, F., Richter, M.: Cells involved in the immune response. XII. The differing responses of normal rabbit lymphoid cells to phytohemagglutinin, goat anti-rabbit immunoglobulin antiserum and allogeneic and xenogeneic lymphocytes. J. exp. Med. 130, 1187–1208 (1969).

    Article  PubMed  CAS  Google Scholar 

  • David, J. R., Schlossman, S. F.: Immunochemical studies on the specificity of cellular hypersensitivity. The in vitro inhibition of peritoneal exudate cell migration by chemically defined antigens. J. exp. Med. 128, 1451–1459 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Diener, E., Armstrong, W. D.: Immunological tolerance in vitro: Kinetic studies at the cellular level. J. exp. Med. 129, 591–603 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Dutton, R.W.: In vitro studies of immunological responses of lymphoid cells. Advan. Immunol. 6, 253–336 (1967).

    Article  CAS  Google Scholar 

  • Dwyer, J. M., Mackay, I. R.: Antigen-binding lymphocytes in human blood. Lancet 1970 I, 164–167.

    Article  Google Scholar 

  • Fazekas de St. Groth, S., Webster, R. G.: Disquisitions on original antigenic sin. 1. Evidence in man. J. exp. Med. 124, 331–345 (1966a).

    Article  Google Scholar 

  • Fazekas de St. Groth, S., Webster, R. G.: Disquisitions on original antigenic sin. II. Proof in lower creatures. J. exp. Med. 124, 347–361 (1966b).

    Article  Google Scholar 

  • Francis, T.: Influenza: The Newe Acquayantance: Ann. intern. Med. 39; 203–221 (1953).

    PubMed  Google Scholar 

  • Gell, P. G. H., Sell, S.: Studies on rabbit lymphocytes in vitro. II. Induction of blast transformation with antisera to six IgG allotypes and summation with mixtures of antisera to different allotypes. J. exp. Med. 122, 813–821 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Gottlieb, A.A.: Studies on the binding of soluble antigens to a unique ribonucleo- protein fraction of macrophage cells. Biochemistry 8, 2111–2116 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Greaves, M. F., Torrigiani, G., Roitt, L M.: Blocking of the lymphocyte receptor site for cell mediated hypersensitivity and transplantation reactions by anti light chain sera. Nature (Lond.) 222, 885–886 (1969).

    Article  CAS  Google Scholar 

  • Henson, P. M.: The adherence of leucocytes and platelets induced by fixed IgG antibody or complement. Immunology 16, 107–121 (1969).

    PubMed  CAS  Google Scholar 

  • Herzenberg, L. A., Goodlin, R. C., Rivera, E. C.: Immunoglobulin synthesis in mice. Suppression by anti-allotype antibody. J. exp. Med. 126, 701–713 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Huber, H., Michlmayr, G., Fudenberg, H. H.: The effect of anti-lymphocyte globulin on human monocytes in vitro. Clin. exp. Immunol. 5, 607–617 (1969).

    PubMed  CAS  Google Scholar 

  • Humphrey, J. H., Keller, H. U.: Some evidence for specific interaction between immunologically competent cells and antigens. In: Developmental aspects of antibody formation and structure (J. Sterzl and I. Riha, eds.). London-New York: Academic Press (in press).

    Google Scholar 

  • Isaković, K., Smith, S. B., Waksman, B. H.: Role of the thymus in tolerance. I. Tolerance to bovine gamma globulin in thymectomized, irradiated rats grafted with thymus from tolerant donors. J. exp. Med. 122, 1103–1123 (1965).

    Article  PubMed  Google Scholar 

  • Jerne, N. K.: Summary: Waiting for the end. In: Cold Spr. Harb. Symp. quant. Biol. 32, 591–603 (1967).

    Article  CAS  Google Scholar 

  • Lay, W. H., Nussenzweig, V.: Receptors for complement on leukocytes. J. exp. Med. 128, 991–1007 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Lay, W. H., Ca++ dependent binding of antigen -19 S antibody complexes to macrophages. J. Immunol. 102, 1172–1178 (1969).

    PubMed  CAS  Google Scholar 

  • Little, J. R., Eisen, H.N.: Specificity of the immune response to the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl groups. Ligand binding and fluorescence properties of crossreacting antibodies. J. exp. Med. 129, 247–265 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Marbrook, J.: Primary immune response in cultures of spleen cells. Lancet 1967 II, 1279–1281.

    Article  Google Scholar 

  • Miller, J. F. A. P., Mitchell, G. F.: Thymus and antigen reactive cells. In: Transplan. Reviews (G. Möller, ed.) 1, 3–42 (1969).

    Google Scholar 

  • Mitchison, N. A.: Antigen recognition responsible for the induction in vitro of the secondary response. In: Cold Spr. Harb. Symp. quant. Biol. 32, 431–439 (1967).

    Article  CAS  Google Scholar 

  • Möller, E., Britton, S., Möller, G.: Homeostatic mechanisms in cellular antibody synthesis and cell-mediated immune reactions. In: Regulation of the antibody response (B. Cinader, ed.), p. 141–181. Springfield, 111.: Ch. C. Thomas 1968.

    Google Scholar 

  • Mosier, D. F., Coppleson, L. W.: A three-cell interaction required for the induction of the primary immune response in vitro. Proc. nat. Acad. Sci. (Wash.) 61, 542–547 (1968).

    Article  CAS  Google Scholar 

  • Naor, D., Bentwich, Z., Cividalli, G.: Inability of peripheral lymphoid cells of agammaglobulinaemic patients to bind radioiodinated albumins. Aust. J. exp. Biol. med. Sci. 47, 759–761 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Naor, D., Bentwich, Z., Cividalli, G. Sulitzeanu, D.: Binding of radioiodinated bovine serum albumin to mouse spleen cells. Nature (Lond.) 214, 687–688 (1967).

    Article  CAS  Google Scholar 

  • Naor, D., Bentwich, Z., Cividalli, G. Sulitzeanu, D.: Affinity of radioiodinated bovine serum albumin for lymphoid cells. Binding of I125 I-BSA to lymphoid cells of immune mice. Israel J. med. Sci. 5, 217–229 (1969 a).

    PubMed  CAS  Google Scholar 

  • Naor, D., Bentwich, Z., Cividalli, G. Sulitzeanu, D.: Binding of 125I-BSA to lymphoid cells of tolerant mice. Int. Arch. Allergy 36, 112–113 (1969b).

    Article  PubMed  CAS  Google Scholar 

  • Naor, D., Bentwich, Z., Cividalli, G. Sulitzeanu, D.: Affinity of radioiodinated bovine serum albumin for lymphoid cells. III. Further experiments with cells of normal animals. Israel J. Med. Sci. (in press).

    Google Scholar 

  • Nisbet, N. W., Simonsen, M., Zaleski, M.: The frequency of antigen-sensitive cells in tissue transplantation. A commentary on clonal selection. J. exp. Med. 129, 459–467 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Nossal, G. J. V., Bussard, A. E., Lewis, H., Mazie, J. C.: Formation of hemolytic plaques by peritoneal cells in vitro. L A new technique enabling micromanipulation and yielding higher plaque numbers. In: Developmental aspects of antibody formation and structure (J. Sterzl and I. Riha, eds.). New York: Academic Press (in press).

    Google Scholar 

  • Nossal, G. J. V., Bussard, A. E., Lewis, H., Mazie, J. C., Williams, G. M., Austin, C.M.: Antigens in immunity. XIII. The antigen content of single antibody forming cells early in primary and secondary immune responses. Aust. J. exp. Biol. med. Sci. 45, 581–594 (1967).

    Article  Google Scholar 

  • Osoba, D.: Restriction of the capacity to respond to two antigens by single precursors of antibody-producing cells in culture. J. exp. Med. 129, 141–152 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Papermaster, B.W.: The clonal differentiation of antibody-producing cells. Cold Spr. Harb. Symp. quant. Biol. 32, 447–460 (1967).

    Article  CAS  Google Scholar 

  • Paul, W. E., Siskind, G. W., Benacerraf, B.: A study of the “termination” of tolerance to BSA with DNP-BSA in rabbits: relative affinities of the antibodies for the immunizing and the paralyzing antigens. Immunology 13,147–15 7 (1967a).

    Google Scholar 

  • Paul, W. E., Siskind, G. W., Benacerraf, B.: Specificity of cellular immune responses. Antigen concentration dependence of stimulation of DNA synthesis in vitro by specifically sensitized cells, as an expression of the binding characteristics of cellular antibody. J. exp. Med. 127, 25–42 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Paul, W. E., Siskind, G. W., Benacerraf, B., Ovary, Z.: Secondary antibody responses in haptenic systems: cell population selection by antigen. J. Immunol. 99, 760–770 (1967b).

    PubMed  CAS  Google Scholar 

  • Playfair, J. H. L.: Strain differences in the immune response of mice. II. Responses by neonatal cells in irradiated adult hosts. Immunology 15, 815–826 (1968).

    PubMed  CAS  Google Scholar 

  • Playfair, J. H. L.: Specific tolerance to sheep erythrocytes in mouse bone marrow cells. Nature (Lond.) 222, 882–883 (1969).

    Article  CAS  Google Scholar 

  • Playfair, J. H. L., Papermaster, B. W., Cole, L.J.: Focal antibody production by transferred spleen cells in irradiated mice. Science 149, 998–1000 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Plescia, O. J.: The role of the carrier in antibody formation. In: Current topics in microbiology and immunology, vol. 50, p. 78–106. Berlin-Heidelberg-New York: Springer 1969.

    Chapter  Google Scholar 

  • Plotz, P. H.: Specific inhibition of an antibody response by affinity labelling. Nature (Lond.) 223, 1373–1374 (1969).

    Article  CAS  Google Scholar 

  • Raff, M. C., Sternberg, M., Taylor, R. B.: Immunoglobulin determinants on the surface of mouse lymphoid cells. Nature (Lond.) 225, 553–554 (1970).

    Article  CAS  Google Scholar 

  • Rajewsky, K., Rottländer, E., Peltre, G., Müller, B.: The immune response to a hybrid protein molecule. Specificity of secondary stimulation and of tolerance induction. J. exp. Med. 126, 581–606 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Rajewsky, K., Rottländer, E., Peltre, G., Müller, B.,Schirrmacher, V., Nase, S., Jerne, N. K.: The requirement of more than one antigenic determinant for immunogenicity. J. exp. Mëd. 129, 1131–1143 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Roitt, I. M., Greaves, M. F., Torrigiani, G., Brostoff, J., Playfair, J. H. L.: The cellular basis of immunological responses. A synthesis of some current views. Lancet 1969 II, 367–371.

    Google Scholar 

  • Schlossman, S. F., Herman, J., Yaron, A.: Antigen recognition: in vitro studies on the specificity of the cellular immune response. J.exp.Med. 130,1031–1045 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Segal, S., Globerson, A., Feldman, M., Haimovich, J., Givol, D.: Specific blocking of antibody synthesis in vitro by affinity labelling reagents. Nature (Lond.) 223, 1374–1375 (1969).

    Article  CAS  Google Scholar 

  • Sela, M., Fuchs, S., Arnon, R.: Studies on the chemical basis of the antigenicity of proteins. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosine. Biochem. J. 85, 223–235 (1962).

    PubMed  CAS  Google Scholar 

  • Sell, S., Gell, P. G. H.: Studies on rabbit lymphocytes in vitro. IV. Blast transformation of the lymphocytes from newborn rabbits induced by anti-allotype serum to a paternal IgG allotype not present in the serum of the lymphocyte donors. J. exp. Med. 122, 923–928 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Shearer, G. M., Cudkowicz, G.: Cellular differentiation of the immune system of mice. III. Separate antigen-sensitive units for different types of anti sheep im- munocytes formed by marrow-thymus cell mixtures. J. exp. Med. 129, 935–951 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Shearer, G. M., Cudkowicz, G., Connell, M., St. James, Priore, R. L.: Cellular differentiation of the immune system of mice. I. Separate splenic antigen sensitive units for different types of anti sheep antibody-forming cells. J. exp. Med. 128, 437–457 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Shearer, G. M., Cudkowicz, G., Priore, R.L.: Cellular differentiation of the immune system of mice. II. Frequency of unipotent splenic antigen-sensitive units after immunization with sheep erythrocytes. J. exp. Med. 129, 185–199 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Siskind, G. W., Dunn, P., Walker, J. G.: Studies on the control of antibody synthesis. II. The effect of antigen dose and of suppression by passive antibody on the affinity of antibody synthesized. J. exp. Med. 127, 55–66 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Staples, P. J., Gery, L, Waksman, B. H.: Role of the thymus in tolerance. III. Tolerance to bovine gamma globulin after direct injection of antigen into the shielded thymus of irradiated rats. J. exp. Med. 124, 127–139 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Steiner, L. A., Eisen, H. N.: Sequential changes in the relative affinity of antibodies synthesized during the immune response. J. exp. Med. 126, 1161–1183 (1967 a).

    Article  PubMed  CAS  Google Scholar 

  • Steiner, L. A., Eisen, H. N.: The relative affinity of antibodies synthesized in the secondary response. J. exp. Med. 126, 1185–1205 (1967b).

    Article  PubMed  CAS  Google Scholar 

  • Stulberg, M., Schlossman, S. F.: The specificity of antigen-induced thymidine- 2-14C incorporation into-lymph node cells from sensitized animals. J. Immunol. 101, 764–769 (1968).

    Google Scholar 

  • Sulitzeanu, D.: Affinity of antigen for white cells and its relation to the induction of antibody formation. Bact. Rev. 32, 404–424 (1968).

    PubMed  CAS  Google Scholar 

  • Sulitzeanu, D., Kleinman, R., Benezra, D., Gery, L: Cellular interactions and the secondary response in vitro. Nature (Lond.) (in press).

    Google Scholar 

  • Sulitzeanu, D., Naor, D.: The affinity of radioiodinated BSA for lymphoid cells. II. Binding of 125I-BSA to lymphoid cells of normal mice. Int. Arch. Allergy 35, 564–578 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Taylor, R. B.: Immune paralysis of thymus cells by Bovine Serum Albumin Nature (Lond.) 220, 611 (1968).

    CAS  Google Scholar 

  • Theis, G. A., Green, I., Benacerraf, B., Siskind, G. W.: A study of immunologic tolerance in the dinitrophenyl poly-L-Lysine immune system. J. Immunol. 102, 513–518 (1969).

    PubMed  CAS  Google Scholar 

  • Uhr, J. W.: Inhibition of antibody formation by serum antibody. In: Regulation of the antibody response (B. Cinader, ed.), p. 114–126. Springfield, Ill.: Ch. C. Thomas 1968.

    Google Scholar 

  • Warren, L., Glick, M. C.: The metabolic turnover of the surface membrane of the I. cell. In: Biological properties of the mammahan surface membrane. The Wistar Institute Symposium monograph No 8 (L. A. Manson, ed.), p. 3–15. Philadelphia: The Wistar Institute Press 1968.

    Google Scholar 

  • Wigzell, H., Anderson, B.: Cell separation on antigen-coated columns. Elimination of high rate antibody-forming cells and immunological memory cells. J. exp. Med. 129, 23–36 (1969).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, Hebrew University — Hadassah Medical School, Israel

    D. Sulitzeanu

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  1. D. Sulitzeanu
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Editors and Affiliations

  1. Berkeley, USA

    W. Arber

  2. New Brunswick, USA

    W. Braun

  3. Göttingen, Germany

    F. Cramer

  4. Freiburg, Germany

    R. Haas

  5. Philadelphia, USA

    W. Henle  & H. Koprowski  & 

  6. München, Germany

    P. H. Hofschneider

  7. Basel, Switzerland

    N. K. Jerne

  8. Prague, Czech Republic

    P. Koldovský  & L. Syruček  & 

  9. Copenhagen, Denmark

    O. Maaløe

  10. Gieβen, Germany

    R. Rott

  11. Wilhelmshaven, Germany

    H. G. Schweiger

  12. Rehovoth, Israel

    M. Sela

  13. Seattle, USA

    P. K. Vogt

  14. Würzburg, Germany

    E. Wecker

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Sulitzeanu, D. (1971). Antibody-like Receptors on Immunocompetent Cells. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65123-6_1

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