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The 67-kDa Laminin Receptor and Tumor Progression

  • Chapter
Attempts to Understand Metastasis Formation I

Part of the book series: Current Topics in Microbiology 213/I and Immunology ((CT MICROBIOLOGY,volume 213/1))

Abstract

Penetration of host basement membranes by maligant cells is the critical event in tumor invasion and metastasis. Basement membranes are specialized extracellular matrices that underlie epithelia and endothelia and surround muscle, nerve,and fat. The major glycoprotein of the basement membrane is laminin, a large, multidomain protein (BECK et al.1990). Cancer cells need to cross host basement membranes several times during the metastatic cascade: when detaching from the primary tumor, during intra- and extravasation, and at the metastatic site during the penetration of organ parenchyma, muscles, and nerves. It has been hypothesized that the attachment of tumor cells via cell-surface receptors to components of the basement membrane, and in particular to laminin, is the prerequisite for basement membrane penetration (LIOTTA 1986). Normal and cancer cells express a variety of cell-surface proteins that are capable of binding to laminin (MERCURIO1990). Laminin receptors include several integrins (ABELDAand BUCK 1990), as well as a variety of nonintegrin proteins (MERCURIOI 990), including a 67-kDa high-affinity laminin receptor.

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References

  • Abelda S, Buck CA (1990) Integrins and other adhesion molecule. FASEB J 4: 2868–2880.

    Google Scholar 

  • Auth D, Brawerman G (1992) A 33 kDa polypeptide with homology to the laminin receptor: component of the translation machinery. Proc Natl Acad Sci USA 89: 4368–4372.

    Article  PubMed  CAS  Google Scholar 

  • Axelos M, Bardet C, Lescure B (1993) An Arabidopsis cDNA encoding a 33-kilodalton laminin receptor homolog. Plant Physiol 103: 299–300.

    Article  PubMed  CAS  Google Scholar 

  • Barsky SH, Rao CN, Williams JE, Liotta LA (1984) Laminin molecular domains which alter metastasis in a murine model. J Clin Invest 74: 843–848.

    Article  PubMed  CAS  Google Scholar 

  • Beck K, Hunter I, Engel J (1990) Structure and function of laminin: anatomy of a multidomain glycoprotein. FASEB J 4: 148–160.

    PubMed  CAS  Google Scholar 

  • Campo E, Monteagudo C, Castronovo V, Claysmith AP, Fernandez PL, Sobel ME (1992) Detection of laminin receptor mRNA in human cancer cell lines and colorectal tissues by in situ hybridization. Am J Pathol 141: 1073–1083.

    PubMed  CAS  Google Scholar 

  • Castronovo V (1993) Laminin receptors and laminin binding proteins during tumor invasion and metastasis. Invasion Metastasis 13: 1–30.

    PubMed  CAS  Google Scholar 

  • Castronovo V, Colin C, Claysmith AP, Chen PH, Lifrange E, Lambotte R, Krutzsch HC, Liotta LA, Sobel ME (1990) Immunodetection of the metastasis-associated laminin receptor in human breast cancer cells obtained by fine needle aspiration biopsy. Am J Pathol 137: 1373–1381.

    PubMed  CAS  Google Scholar 

  • Castronovo V, Claysmith AP, Barker KT, Cioce V, Krutzsch HC, Sobel ME (1991 a) Biosynthesis of the 67 kD high affinity laminin receptor. Biochem Biophys Res Commun 177: 177–183.

    Article  PubMed  CAS  Google Scholar 

  • Castronovo V, Taraboletti G, Sobel ME (1991b) Functional domains of the 67kDa laminin receptor precursor. J Biol Chem 226: 20440–20446.

    Google Scholar 

  • Castronovo V, Taraboletti G, Sobel ME (1991c) Laminin receptor complementary DNA-deduced synthetic peptide inhibits cancer cell attachment to endothelium. Cancer Res 51: 5672–5678.

    PubMed  CAS  Google Scholar 

  • Castronovo V, Campo E, Van den Brule FA, Claysmith AP, Cioce V, Liu FT, Fernandez P, Sobel ME (1992) Inverse modulation of steady-state messenger RNA levels of two nonintegrin laminin-binding proteins in human colon carcinoma. J Natl Cancer Inst 84: 1161–1169.

    Article  PubMed  CAS  Google Scholar 

  • Cioce V, Castronovo V, Shmookler BM, Garbisa S, Grigioni WF, Liottai_A, Sobel ME (1991) Increased expression of the laminin receptor in colon cancer. J Natl Cancer Inst 83: 29–36.

    Article  PubMed  CAS  Google Scholar 

  • Cioce V, Marguiles IMK, Sobel ME, Castronovo V (1993) Interaction between the 67 kilodalton metastasis-associated laminin receptor and laminin. Kidney Int 43: 30–37.

    Article  PubMed  CAS  Google Scholar 

  • Colnaghi Ml (1994) The simultaneous expression of c-erbB-2 oncoprotein and laminin receptor on primary breast tumors has a predicting potential analogous to that of the limph node status. Adv Exp Med Biol 353: 149–154.

    Google Scholar 

  • Daidone MG, Silvestrini R, D’Errico A, Di FG, Benini E, Mancini AM, Garbisa S, Liotta LA, Grigioni WF (1991) Laminin receptors, collagenase IV and prognosis in node negative breast cancers. Int J Cancer 48: 529–532.

    Article  PubMed  CAS  Google Scholar 

  • Davis SC, Tzagoloff A, Ellis SR (1992) Characterization of a yeast mitochondrial ribosomal protein structurally related to the mammalian 68 kDa high affinity laminin receptor. J Biol Chem 267: 5508–5514.

    PubMed  CAS  Google Scholar 

  • Demeter LM, Stoler MH, Sobel ME, Broker TR, Chow LT (1992) Expression of high affinity laminin receptor mRNA correlates with cell proliferation rather than invasion in human pappilloma-virus-associated cervical neoplasm. Cancer Res 52: 1561–1567.

    PubMed  CAS  Google Scholar 

  • D’Errico A, Garbisa S, Liotta LA, Castronovo V, Stetler-Stevenson WG, Grigioni WF (1991) Augmentation of type IV collagenase, laminin receptor and Ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression. Mol Pathol 4: 239–246.

    Google Scholar 

  • Engel J, Odermatt E, Engel A, Madri JA, Furthmayr H, Rohde H, Timpl R (1981) Shapes, domain Organization and flexibility of laminin and fibronection, two multifunctional proteins of the extracellular matrix. J Mol Biol 150: 97–120.

    Article  PubMed  CAS  Google Scholar 

  • Ferrarini M, Pupa SM, Zocchi MR, Rugarli C, Menard S (1994) Distinct pattern of HSP72 and monomeric laminin receptor expression in human lung cancers infiltrated by gamma/delta T lymphocytes. Int J Cancer 57: 486–490.

    Article  PubMed  CAS  Google Scholar 

  • Gasparini G, Barbareschi M, Boracchi P, Bevilacqua P, Verderio P, Dalla Palma P, Menard S (1995) 67 kDa laminin receptor expression adds prognostic information to intra-tumoral microvessel density in node-negative breast cancer. Int J Cancer 60: 604–610.

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Hernandez M, Davies E, Staswick PE (1994) Arabidopsis p40 homologue: a novel acidic protein associated with the 40 S subunit of ribosomes. J Biol Chem 269: 20744–20749.

    PubMed  CAS  Google Scholar 

  • Graf J, Ogle RC, Robey FA, Sasaki M, Martin GR, Yamada Y, Kleinman HK (1987) A pentapeptide from the laminin betal chain mediates cell adhesion and binds to the 67,000 laminin receptor. Biochemistry 26: 6896–6900.

    Article  PubMed  CAS  Google Scholar 

  • Grigiom WF, Garbisa S, D’Errico A, Baccarini P, Stetler-Stevenson WG, Liotta LA, Mancini AM (1991) Evaluation of hepatocellular carcinoma aggressiveness by a panel of extracellular matrix antigens. Am J Pathol 138: 647–654.

    Google Scholar 

  • Grosso LE, Park PW, Mecham RP (1991) Characterization of a putative clone for the 67 kDa elastin-laminin receptor suggests that it encodes a cytoplasmic protein rather than a cell surface receptor. Biochemistry 50: 3346–3350.

    Article  Google Scholar 

  • Guo N, Krutzsch HC, Vogel T, Roberts DD (1992) Interaction of a laminin binding peptide from a 33 kDa protein related to the 67 kDa laminin receptor with laminin and melanoma cells are heparin dependent. J Biol Chem 267: 17743–17747.

    PubMed  CAS  Google Scholar 

  • Horan-Hand P, Thor A, Schlom J, Rao CN, Liotta LA (1985) expression of laminin receptor in normal and carcinomatous tissues as defined by a monoclonal antibody. Cancer Res 45: 2713–2719.

    Google Scholar 

  • Keppel E, Schaller HC(1991) A 33 kDa protein with homology to the “laminin binding protein” is associated with cytoskeleton in hydra and in mammalian cells. J Cell Sci 100: 789–797.

    Google Scholar 

  • Kim YJ, Baker BS (1991) EMBL Databank Accession Number M77133 Kondoh N, Schweinfest CW, Henderson KW, Papas TS (1992) Differential expression of S19 ribosomal protein, laminin binding protein and human lymphocyte antigen class I messenger RNAs associated with colon carcinoma progression and differentiation. Cancer Res 52: 791–796.

    Google Scholar 

  • Lesot LA, Kühl U, Von der Mark K (1983) Isolation of a laminin binding protein from muscle cell membrane. EMBO J 2: 861–865.

    PubMed  CAS  Google Scholar 

  • Liotta H (1986) Tumor invasion and metastasis-role of the extracellular matrix. Rhoads Memorial Award lecture. Cancer Res 46: 1–7.

    CAS  Google Scholar 

  • Liotta LA, Horan-Hand P, Rao CN, Bryant G, Barsky SH, Schlom J (1985) Monoclonal antibodies to the human laminin receptor recognize structurally distinct sites. Exp Cell Res 156: 117–126.

    Article  PubMed  CAS  Google Scholar 

  • Mafune K, Ravikumar TS (1992) Antisense RNA of 32kDa laminin binding protein inhibits attachment and invasion of a human colon carcinoma cell line. J Surg Res 52: 340–346.

    Article  PubMed  CAS  Google Scholar 

  • Makrides S, Chitpatima ST, Bandyopadhyay R, Brawerman G (1988) Nucleotide sequence for a major messenger RNA for a 40 kilodalton polypeptide that is under translational control in mouse tumor cells. Nucleic Acids Res 16: 2349.

    Article  PubMed  CAS  Google Scholar 

  • Malinoff HL, Wicha MS (1983) Isolation of a cell surface receptor protein for laminin from murine fibrosarcoma cells. J Cell Biol 96: 1475–1479.

    Article  PubMed  CAS  Google Scholar 

  • Martignone S, Pellegrini R, Villa E, Tandon NN, Mastoiani A, Tagliabue E, Menard S, Colnaghi Ml (1992) Characterization of two monoclonal antibodies directed against the 67 kDa high affinity laminin receptor and application for the study of breast carcinoma progression. Clin Exp Metastasis 10: 379–386.

    Article  PubMed  CAS  Google Scholar 

  • Martignone S, Menard S, Bufalino R, Cascinelli N, Pellegrini R, Tagliabue E, Andreola S, Rilke F, Colnagh Ml (1993) Prognostic significance of the 67 kilodalton laminin receptor expression in human breast carcinomas. J Natl Cancer Inst 85: 398–402.

    Article  PubMed  CAS  Google Scholar 

  • Mc Caffrey P, Neve RL, Drager UC (1990) A dorso-ventral asymmetry in the embryonic retina defined by protein conformation. Proc Natl Acad Sci USA 87: 8570–8574.

    Article  Google Scholar 

  • Mecham RP, Hinek A, Griffin GL, Senior RM, Liotta LA (1989) The elastin receptor shows structural and functional similarities to the 67 kDa tumor laminin receptor. J Biol Chem 264: 16652–16657.

    PubMed  CAS  Google Scholar 

  • Menard S, Squicciarini P, Luini A, Sacchini V, Rovini D, Tagliabue E, Veronesi P, Salvadori B, Veronesi U, Colnaghi Ml (1994) Immunodetection of bone marrow micrometastases in breast carcinoma patients and its correlation with primary tumor prognostic features. Br J Cancer 69: 1126–1129.

    Article  PubMed  CAS  Google Scholar 

  • Mercurio AM (1990) Laminin: multiple forms, multiple receptors. Curr Opin Cell Biol 2: 845–849.

    Article  PubMed  CAS  Google Scholar 

  • Minafra S, Luparello C, Pucci-Minafra I, Sobel ME, Garbisa S (1992) Adhesion of 8701-BC breast cancer cells to type V collagen and 67 kDa receptor. J Cell Sci 102: 323–328.

    PubMed  CAS  Google Scholar 

  • Rabacchi SA, Neve RL, Drager UC (1990) A positional marker for the dorsal embryonic retina is homologous to the high affinity laminin receptor. Development 109: 521–531.

    PubMed  CAS  Google Scholar 

  • Rahman A, Panneerselvam M, Guirguis R, Castronovo V, Sobel ME, Abraham K, Daddona PE, Liotta LA (1989) Anti-laminin receptor antibody targeting of liposomes with encapsulated doxorudicin to human breast cancer cells in vitro. J Natl Cancer Inst 81: 1794–1800.

    Article  PubMed  CAS  Google Scholar 

  • Rao CN, Barsky SH, Terranova VP, Liotta LA (1983) Isolation of a tumor cell laminin receptor, Biochem Biophys Res Commun 111: 804–808.

    Article  PubMed  CAS  Google Scholar 

  • Rao CN, Castronovo V, Schmitt MC, Wewer UM, Claysmith AP, Liotta LA, Sobel ME (1989) Evidence for a precursor of the high affinity metastasis-associated murine laminin receptor. Biochemistry 28: 7476–7486.

    Article  PubMed  CAS  Google Scholar 

  • Rao M, Manishen WJ, Maheswari Y, Sykes DE, Sijanova EY, Tyner AL, Weiser MM (1994) Laminin receptor expression in rat intestine and liver during development and differentiation. Gastroenterology 107: 764–772.

    Article  PubMed  CAS  Google Scholar 

  • Romanoy VI, Sobel ME, Pinto da Silva P, Menard S, Castronovo V (1994) Cell localization and redistribution of the 67kDa laminin receptor and alpha 6 beta 1 integrin subunits in response to laminin stimulation: an immunogold electron microscopy study. Cell Adhes Commun 2: 201–209.

    Article  Google Scholar 

  • Romanov VI, Wrathall LS, Simmons TD, Pinto da Silva P, Sobel ME (1995) Protein synthesis is required for laminin-induced expression of the 67 kDa laminin receptor and its 37 kDa precursor. Biochem Biophys Res Commun 208: 637–643.

    Article  PubMed  CAS  Google Scholar 

  • Senior RM, Hinek A, Griffin GL, Pipoly DJ, Crouch EC, Mecham RP (1989) Neutrophils show Chemotaxis to type IV collagen and its 7S domain and contain a 67-kD type IV collagen-binding protein with lectin properties. Am J Resp Cell Mol Biol 1: 479–489.

    CAS  Google Scholar 

  • Siyanova EY (1992) Expression of LBP32/67 human gene in E. coli and analysis of its binding with laminin. Bull Exp Biol Med 113: 101–104.

    Article  Google Scholar 

  • Sobel ME (1993) Differential expression of the 67 kDa laminin receptor in cancer. Semin Cancer Biol 4: 311–317.

    PubMed  CAS  Google Scholar 

  • Taraboletti G, Belotti D, Giavazzi R, Sobel ME, Castronovo V (1993) Enhancement of metastatic potential of murine and melanoma cells by laminin receptor peptide G: attachment to subendothelial matrix as a pathway for hematogenous metastasis. J Natl Cancer Inst 85: 235–240.

    Article  PubMed  CAS  Google Scholar 

  • Van den Brule FA, Price J, Sobel ME, Lambotte R, Castronovo V (1994a) Inverse expression of two laminin binding proteins, 67LR and galectin-3, correlates with the invasive phenotype of throphoblastic tissue. Biochem Biophys Res Commun 201: 388–393.

    Article  PubMed  Google Scholar 

  • Van den Brule FA, Berchuck A, Bast RC, Tong Liu F, Gillet C, Sobel ME, Castronovo V (1994b) Differential expression of the 67-kD laminin receptor and 31 kD human laminin-binding protein in human ovarian carcinomas. Eur J Cancer 30A: 1096–1099.

    Article  PubMed  Google Scholar 

  • Van den Ouweland AMW, Van Duijnhoven HLP, Deichman KA, van Groningen JJM, de Leij L, Van de Ven WJM (1989) Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes. Nucleic Acids Res 17: 3829–3843.

    Article  PubMed  Google Scholar 

  • Wewer UM, Liotta LA, Jaye M, Ricca GA, Drohan WN, Claysmith AP, Rao CN, Wirth P, Coligan JE, Albrechtsen R, Mudryi M, Sobel ME (1986) Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilites to bind laminin, Proc Natl Acad Sci USA 83: 7137–7141.

    Google Scholar 

  • Yow H, Wong JM, Chen HS, Lee C, Steel GDJ, Chen LB (1988) Increased mRNA expression of a laminin binding protein in human colon carcinoma: complete sequence of a f ull length cDNA encoding protein. Proc Natl Acad Sci USA 85: 6394–6398.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. N. Montuori
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  2. M. E. Sobel
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Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Ursula Günthert Ph.D., P.D.

  2. Max-βDelbrūck-Centrum für Molekulare Medizin, Robert-Rōssle-Straße 10, D-13122, Berlin, Germany

    Walter Birchmeier Ph.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Montuori, N., Sobel, M.E. (1996). The 67-kDa Laminin Receptor and Tumor Progression. In: Günthert, U., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation I. Current Topics in Microbiology 213/I and Immunology, vol 213/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61107-0_13

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  • DOI: https://doi.org/10.1007/978-3-642-61107-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64697-3

  • Online ISBN: 978-3-642-61107-0

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