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The Structure of Coxsackievirus B3

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The Coxsackie B Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 223))

Abstract

Picornaviruses are small, nonenveloped, icosahedral viruses. The mature virions are approximately 300 Å in diameter and the interior of the capsid shell is packed with single-stranded plus sense RNA (Mw ∼ 8×106 Daltons) (Rueckert 1990). The virus capsid is composed of 60 protomers, each consisting of one copy of the viral proteins VP1, VP2, VP3 and VP4 arranged in a T= 1 (Pseudo T = 3) icosahedral lattice (CASPAR and KLUG 1962) (Fig. 1). Atomic resolution structures have been determined for all Picornaviridae genera (Hogle et al. 1985; Rossmann et al. 1985; Luo et al. 1987; Acharya et al. 1989) with the exception of the hepatoviruses. Their structures demonstrate conservation of the eight-stranded antiparallel β-sandwich of VP1, VP2 and VP3 while VP4, which is completely interior, is not well defined in many of the structures. The regions of most structural dissimilarity for VP1, VP2 and VP3 occurs at the NH2- and COOH-terminals and the loops that connect the β-strands. Many of the differences at the COOH-terminals and β-strand loops present themselves on the surface of the virion and give each virus its unique surface topology and hence define how these viruses interact with cells and mediate early steps in the viral life cycle including receptor recognition and viral uncoating.

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Authors and Affiliations

  1. Department of Biological Sciences, Purdue University, 1392 Lilly Hall of Life Science, West Lafayette, IN, 47907, USA

    J. K. Muckelbauer & M. G. Rossmann

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  1. J. K. Muckelbauer
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  2. M. G. Rossmann
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Editors and Affiliations

  1. Department of Pathology and Microbiology, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE, 69198-6495, USA

    Steven Tracy Ph.D. (Professor) & Nora M. Chapman Ph.D. (Assistant Professor) (Professor) &  (Assistant Professor)

  2. National Center for Infectious Diseases, Centers for Disease Control and Prevention, Clifton Road, Atlanta, GA, 30333, USA

    Brian W. J. Mahy Ph.D., Sc.D. (Director of Viral and Rickettsial Diseases) (Director of Viral and Rickettsial Diseases)

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© 1997 Springer-Verlag Berlin Heidelberg

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Muckelbauer, J.K., Rossmann, M.G. (1997). The Structure of Coxsackievirus B3. In: Tracy, S., Chapman, N.M., Mahy, B.W.J. (eds) The Coxsackie B Viruses. Current Topics in Microbiology and Immunology, vol 223. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60687-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-60687-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64507-5

  • Online ISBN: 978-3-642-60687-8

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