Skip to main content

Effects of Nutritional Antioxidants and Other Dietary Constituents on Coxsackievirus-Induced Myocarditis

  • Chapter
The Coxsackie B Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 223))

Abstract

Nutrition of the host has been largely neglected in studies of viral pathogenesis. Much more emphasis has been placed on the effect of nutrition on the host’s immune system. A functioning immune system is required for both initial protection from viral illness as well as subsequent viral clearance once the pathogen has gained entrance to the host. Any perturbation of the immune system induced by a change in host nutritional status would be expected to affect the course of a viral infection. For example, severely malnourished children are more susceptible to infection and severe disease with rotavirus, which is thought to be due in part to a dysfunctional immune response (DAGAN et al. 1990). Therefore, the vast majority of nutrition research related to viral infection has emphasized the effect of nutrition on the host immune system, which in turn leads to a change in host susceptibility to infectious disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bai J, Wu S, Ge K, Deng X, Su C (1980) The combined effect of selenium deficiency and viral infection on the myocardium of mice. Acta Acad Med Sinica 2:31–33

    Google Scholar 

  • Beck MA, Kolbeck PC, Shi A, Rohr LH, Morris VC, Levander OA (1994a) Increased virulence of a human enterovirus (coxsackievirus B3) in selenium-deficient mice. J Infect Dis 170:351–357

    Article  PubMed  CAS  Google Scholar 

  • Beck MA, Kolbeck PC, Rohr LH, Shi Q, Morris VC, Levander OA (1994b) Benign human enterovirus becomes virulent in selenium-deficient mice. J Med Virol 43:166–170

    Article  PubMed  CAS  Google Scholar 

  • Beck MA, Kolbeck PC, Rohr LH, Shi Q, Morris VC, Levander OA (1994c) Vitamin E deficiency intensifies the myocardial injuiy of coxsackievirus B3 infection of mice. J Nutr 124:345–358

    PubMed  CAS  Google Scholar 

  • Beck MA, Shi Q, Morris VC, Levander OA (1995) Rapid genomic evolution of a non-virulent Coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates. Nat Med 1:433–436

    Article  PubMed  CAS  Google Scholar 

  • Beck MA, Shi Q, Morris VC, Levander OA (1996) From avirulent to virulent: Vitamin E deficiency in mice drives rapid genomic evolution of a coxsackie B3 virus. FASEB J 10:A191

    Google Scholar 

  • Chapman, N.M., Tu, Z., Tracy, S., Gauntt, C.J. (1994) An infectious cDNA copy of the genome of a noncardiovirulent coxsackievirus B3 strain: its complete sequence analysis and comparison to the genomes of cardiovirulent coxsackieviruses. Arch Virol 134:115–130.

    Article  Google Scholar 

  • Chen Y, Saari JT, Kang YJ (1994) Weak antioxidant defenses make the heart a target for damage in copper-deficient rats. Free Rad Biol Med 17:529–536

    Article  PubMed  CAS  Google Scholar 

  • Dagan R, Bar-David Y, Sarov B, Katz M, Kassis I, Greenberg D, Glass RI, Margolis CZ, Sarov I (1990) Rotavirus diarrhea in Jewish and Bedouin children in the Negev region of Israel: epidemiology, clinical aspects and possible role of malnutrition in severity of illness. Ped Inf Dis J 9:314–321

    Article  CAS  Google Scholar 

  • Davies KJA, Quintanilha T, Brooks GA, Packer L (1982) Free radicals and tissue damage produced by exercise. Biochem Biophy Res Commun 107:1178–1205

    Google Scholar 

  • Ganther HE (1980) Interactions of vitamin E and selenium with mercury and silver. In: Levander OACheng L (eds) Micronutrient interactions: vitamins, minerals, and hazardous elements, Annals of the NY Acad Sci, vol. 355, New York Acadademy of Sciences, New York, pp 212–226

    Google Scholar 

  • Gatmaitan BG, Chason JL, Lerner AM (1970) Augmentation of the virulence of murine coxsackievirus B-3 myocardiopathy by exercise. J Exp Med 131:1121–1136

    Article  PubMed  CAS  Google Scholar 

  • Gauntt CJ, Godeny EK, Lutton CW, Fernandes G (1989) Role of natural killer cells in experimental murine myocarditis. Springer Semin Immunopathol 11:51–59

    Article  PubMed  CAS  Google Scholar 

  • Gauntt CJ, Trousdale MD, LaBadie DRL, Paque RE, Nealon T (1979) Properties of coxsackievirus B3 variants which are amyocarditic or myocarditic for mice. J Med Virol 3:207–220

    Article  PubMed  CAS  Google Scholar 

  • Ge KY, Xue A, Bai J (1983) Keshan disease- an endemic cardiomyopathy in China. Virchows Arch {A} 401:1–14

    Article  CAS  Google Scholar 

  • Gu BQ (1983) Pathology of Keshan disease. A comprehensive review. Chinese Med J 96:251–261

    CAS  Google Scholar 

  • Halliwell B, Gutteridge JMC, Cross CE (1992) Free radicals, antioxidants, and human disease: Where are we now? J Lab Clin Med 119:598–620

    PubMed  CAS  Google Scholar 

  • Hiraoka Y, Kishimoto C, Masahiko K, Ochiai H, Sasayama S (1992) Effects of polyethylene glycol conjugated superoxide dismutase on coxsackievirus B3 myocarditis in mice. Cardiovas Res 26:956–961

    Article  CAS  Google Scholar 

  • Hiraoka Y, Kishimoto C, Takada H, Durokawa M, Ochiai H, Shiraki K, Sasayama S (1993) Role of oxygen derived free radicals in the pathogenesis of coxsackievirus B3 myocarditis in mice. Cardiovas Res 27:957–961

    Article  CAS  Google Scholar 

  • Ilback N-G, Mohammed A, Fohlman J, Friman G (1976) Cardiovascular lipid accumulation with coxsackievirus infection in mice. Am J Pathol 136:159–167

    Google Scholar 

  • Ilback N-G, Fohlman G, Friman G (1989a) Protective effect of selenium on the development of coxsackievirus B3-induced inflammatory lesions in the murine myocardium. J Trace Elements Exp Med 2:257–266

    Google Scholar 

  • Ilback N-G, Fohlman J, Friman G (1989b) Exercise in coxsackie B3 myocarditis: Effects on heart lymphocyte subpopulations and the inflammatory reaction. Am Heart J 117:1298–1302

    Article  PubMed  CAS  Google Scholar 

  • Ilback N-G, Fohlman J, Friman G (1992a) A common viral infection can change nickel target organ distribution. Toxicol Appl Pharmacol 114:166–170

    Article  PubMed  CAS  Google Scholar 

  • Ilback N-G, Fohlman J, Friman G, Glynn AW (1992b) Altered distribution of 109cadmium in mice during viral infection. Toxicol 71:193–202

    Article  CAS  Google Scholar 

  • Ilback N-G, Fohlman J, Friman G (1995a) Selenium (Se) supplementation decreases myocardial injury and increases survival in coxsackie B3 (CB3) virus infected mice. J Invest Med 43:269A

    Google Scholar 

  • Ilback N-G, Lindh U, Wesslso L, Fohlman J, Priman G (1995b) Heart trace elements are changed after viral infection (coxsackie B3) in methyl mercury exposed mice. J Invest Med 43:269A

    Google Scholar 

  • Jin S (1984) III. Keshan disease in children. Chinese Med 2: 348–352

    Google Scholar 

  • Keshan Disease Research Group of the Chinese Academy of Medical Sciences (1979) Observations on effect of sodium selenite in prevention of Keshan disease. Chin Med J 92:471–476

    Google Scholar 

  • Kumar CT, Reddy VK, Prasad M, Thyagaraju K, Reddanna P (1992) Dietary supplementation of vitamin E protects heart tissue from exercise-induced oxidant stress. Mol Cell Biochem 111:109–115

    Article  PubMed  CAS  Google Scholar 

  • Li G, Wang F, Kang D, Li C. (1985) Keshan disease: an endemic cardiomyopathy in China. Hum Path 16: 602–609

    Article  PubMed  CAS  Google Scholar 

  • Li Y, Zhang H, Yang Y, Chen H, Archard LC (1995) High prevalence of enteroviral genomic sequences in an endemic cardiomyopathy (Keshan disease) detected by nested polymerase chain reaction. Progress in Clinical Virology 1995 Joint Meeting, Prague, Czech Republic, pg 172

    Google Scholar 

  • Loria RM, Kibrik S, Madge GE (1976) Infection of hypercholesterolemic mice with coxsackievirus B. J Inf Dis 133:655–662

    Article  CAS  Google Scholar 

  • Meeker HC, Eskew ML, Scheuchenzuber W, Scholz RW, Zarkower A (1985) Antioxidant effects on cellmediated immunity. J Leuk Biol 38:451–158

    CAS  Google Scholar 

  • National Research Council. Committee on Medical and Biologic Effects of Environmental Pollutants (1976) Selenium. Division of Medical Sciences, Assembly of Life Sciences, National Academy of Sciences, National Academy Press, Washington DC

    Google Scholar 

  • Reyes MP, Thomas JA, Ho KL, Smith FE, Lerner AM (1982) Elevated thymocyte norepinephrine and cyclic guanosine 3’,5’ monophosphate in sensitized T-lymphocytes from exercised mice with coxsackievirus B-3 myocarditis. Biochem Biophys Res Commun 109:701–708

    Article  Google Scholar 

  • Roath PD, Beck MA, Chen X, Xue A, Wang S, Levander OA (1996) Detection of enterovirus RNA from heart tissue blocks and blood obtained from a Keshan disease endemic area of China using reverse transcriptase-polymerase chain reaction (RT-PCR). FASEB J 10:A537

    Google Scholar 

  • Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179:585–590

    Article  Google Scholar 

  • Schwarz K, Foltz CM (1957) Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J Am Chem Soc 79:3292–3293

    Article  CAS  Google Scholar 

  • Su C, Gong C, Li J, Chen L, Zhou D, Jin Q (1979) Preliminary results of viral etiology of Keshan disease. Chinese J Med 59:466–172

    Google Scholar 

  • Taylor EW, Ramanathan C, Madimpalli RG (1996) A general method for predicting potential new genes in nucleic acid sequences: application to the human immunodeficiency virus. In: Witten M (ed) Computational medicine, public health and technology. World Scientific, London, 1:285–309

    Google Scholar 

  • Taylor EW, Ramanathan CS, Jalhari RK, Nadimpalli RG (1994) A basis for new approaches to the chemotherapy of AIDS: novel genes in HIV-1 potentially encode selenoproteins expressed by ribosomal frameshifting and termination suppression. J Med Chem 37:2637–2654

    Article  PubMed  CAS  Google Scholar 

  • Tracy S, Chapman N, Tu Z (1992) Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice. Arch Virology 122:399–409.

    Article  CAS  Google Scholar 

  • Whanger PD, Ridlington JW, Holcomb CL (1980) Interactions of zinc and selenium on the binding of cadmium to rat tissue proteins. In: Levander OACheng L (eds) Micronutrient interactions: vitamins, minerals, and hazardous elements. Annals of the NY Acad Sci, New York Academy of Sciences, New York vol. 355 pp 333–346

    Google Scholar 

  • Woodruff JF (1970) The influence of quantitated post-weaning undernutrition on coxsackievirus B3 infection of adult mice. II. Alteration of host defense mechanisms. J Inf Dis 121: 164–181

    Article  CAS  Google Scholar 

  • Woodruff JF, Kilbourne ED (1970) The influence of quantitated post-weaning undernutrition on coxsackievirus B3 infection of adult mice. I. Viral persistence and increased severity of lesions. J Inf Dis 121: 137–163

    Article  CAS  Google Scholar 

  • Yu WH (1981) Analysis of the incidence of Keshan disease in 25 years in Heilongjiang province. Chinese J Epidemiol 2: 26–34

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Beck, M.A., Levander, O.A. (1997). Effects of Nutritional Antioxidants and Other Dietary Constituents on Coxsackievirus-Induced Myocarditis. In: Tracy, S., Chapman, N.M., Mahy, B.W.J. (eds) The Coxsackie B Viruses. Current Topics in Microbiology and Immunology, vol 223. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60687-8_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60687-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64507-5

  • Online ISBN: 978-3-642-60687-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics