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Roles of T Cells in Coxsackievirus B-Induced Disease

  • Chapter
The Coxsackie B Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 223))

Abstract

Enteroviral infection, for example by coxsackieviruses, is thought to be the initiating event of human myocarditis. This is supported by epidemiological studies showing an increased incidence of viral myocarditis following endemics of coxsackie B virus (CVB) infections (Helin et al. 1968). However, the assumed pathogenetic role of enteroviral infection in the pathogenesis of viral myocarditis was established only in the last decade, by the demonstration of enteroviral RNA in the myocardium of patients with myocarditis and dilated cardiomyopathy using molecular biological methods (Bowles et al. 1986). The percentage of patients with myocarditis having enteroviral sequences in the myocardium differs widely between different studies, possibly due to different probes used for hybridization, differences in the primers selected for amplification or unspecific contamination with viral RNA especially in the polymerase chain reaction, thus giving false positive results. In general and in studies testing more than 100 patients for the presence of enteroviral RNA in the myocardium, about 30%–40% of the patients were positive.

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Authors and Affiliations

  1. Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University, Hindenburgdamm 30, 12200, Berlin, Germany

    P. L. Schwimmbeck & H.-P. Schultheiss

  2. Department of Pathology, College of Medicine, University of Vermont, Burlington, VT, USA

    S. A. Huber

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  1. P. L. Schwimmbeck
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  2. S. A. Huber
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  3. H.-P. Schultheiss
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Editors and Affiliations

  1. Department of Pathology and Microbiology, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE, 69198-6495, USA

    Steven Tracy Ph.D. (Professor) & Nora M. Chapman Ph.D. (Assistant Professor) (Professor) &  (Assistant Professor)

  2. National Center for Infectious Diseases, Centers for Disease Control and Prevention, Clifton Road, Atlanta, GA, 30333, USA

    Brian W. J. Mahy Ph.D., Sc.D. (Director of Viral and Rickettsial Diseases) (Director of Viral and Rickettsial Diseases)

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Schwimmbeck, P.L., Huber, S.A., Schultheiss, HP. (1997). Roles of T Cells in Coxsackievirus B-Induced Disease. In: Tracy, S., Chapman, N.M., Mahy, B.W.J. (eds) The Coxsackie B Viruses. Current Topics in Microbiology and Immunology, vol 223. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60687-8_13

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