Abstract
This review deals with maternal T cell reactivity in pregnancy. Since other chapters consider recurrent spontaneous abortion in human, we focus(very briefly) only on data in such situations when they cast light on maternal T cell status in normal human pregnancy. It is necessary, however, to deal with abortion models in mice since these are models for study of T cell reactivity during gestation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abastado JP, Jaulin C, Schutze M-P, Langlade-Denoyen P, Plata F, Ozato K, Kourilsky P(1987) Fine mapping of epitopes by intradomain Kd/Dd recombinants. J Exp Med 166:327–340
Allen WR, Kydd JH, Antczack DF(1986) Successful application of immunotherapy to a model of pregnancy failure in equids. In:Clark DA, Croy BA(eds) Reproductive immunology 1986. Elsevier Amsterdam, pp 253–261
Allen WR, Kydd J, Donaldson WL, Oriol JG, Antczak D(1987) Expression of immune response to fetal antigens in equine pregnancy. Coll INSERM 154:255
Allen WR, Kydd JH, Antczak DF(1990) Xenogeneic donkey-in-horse pregnancy created by embryo transfer:immunological aspects of a model of early abortion. In:Chaouat G(ed) The immunology of the foetus. CRC, Boca Raton Amstrong DTA, Chaouat G(1989) Effects of lymphokines and immune complexes on murine placental cell growth in vitro. Biol Reprod 4:400–406
Antczack DF, Allen WR(1984) Invasive trophoblast in the genus Equus. Ann Immunol(Paris) 135 D:325–331
Arck PC, Merali FS, Manuel JS, Chaouat G, Clark DA(1995) Stress triggered abortion:inhibition of protective suppression and promotion of tumor necrosis factor alpha(TNF alpha) release as a mechanism triggering resorptions in mice. Am J Reprod Immunol 33(1):74–81
Athanassakis I, Bleackley RC, Paetkau V, Guilbert L, Barrp J, Wegmann TG(1987) The immunostimulatory effects of T cells and T cell lymphokines on murine foetally derived placental cells. J Immunol 138:37–44
Athanassakis I, Chaouat G, Wegmann TG(1990) The effects of anti CD4 and anti CD8 antibody treatment on placental growth and function in allogenic and syngenic pregnancy. Cell Immunol 129:13–21 118
Athanassakis vassiliadis I, Papamettheakis J(1991) Modulation of class II antigens on fetal placenta lads to fetal abortion. In:Chaouat G, Mowbray J(eds) Biologie cellulaire et moleculaire de la relation materno fetale. Libbey, Paris, pp 69–81
Athanassakis vassiliadis I, Papamettheakis J(1991) Modulation of class II antigens on fetal placenta lads to fetal abortion. In:Chaouat G, Mowbray J(eds) Biologie cellulaire et moleculaire de la relation materno fetale. Libbey, Paris, pp 69–81
Baines MG, Speers EA, Pross HGF, Millar KG(1980a) Characteristics of the maternal lymphoid response in mice to paternal strain alloantigens induced by homologous pregnancy. Immunology 31:363–369
Baines MG, Millar KG, Pross HF(1980b) Allograft enhancement during normal murine pregnancy. J Reprod Immunol 2:141–148
Barg M, Burton RC, Smith J A, Luckenbach GA, Decker J, Mitchell GF(1978) Effect of placental tissues on immunological responses. Clin Exp Immunol 140:1588–1597
Barret DS, Rayfield LS, Brent L(1982) Suppression of natural cell mediated cytotoxicity in man by maternal and neonatal serum. Clin Exp Immunol 47:742–748
Beaman KD, Hoversland RC(1988) Induction of “spontaneous” abortion by blocking antigen specific suppression. J Reprod Fertil 82:135-139 Beer AE, Billingham RE(1973) Maternally acquired runt disease. Science 179:240–243
Beer AE, Billingham RE(1974) Host responses to intrauterine tissues, cellular and fetal allografts. J Reprod Fertil Suppl 21:59
Beer AE, Scott JR, Billingham RE(1975) Histocompatibility and maternal immunological status as determinants of foeto-placental size and litter weight in rodents. J Exp Med 142:180–198
Beer AE, Quebbeman JF, Semprini AE(1983a) Immunological aspects of recurrent abortions in humans. In:Edelmann P, Sureau C(eds) Immunologic de la Reproduction humaine. Sandoz, Basel
Beer AE, Quebbeman JF, Semprini AE, Smouse PE, Haines RF(1983b) Recurrent abortion:analysis of the role of parental sharing of histocompatibility antigens and maternal immunological responses to paternal antigens. In:Isojima S, Billington WD(eds) Reproductive immunology 1983. Elsevier, Amsterdam, pp 185–197
Bell SC, Billington WD(1980) Major antipaternal alio antibody induced by pregnancy is non complement fixing lgGl. Nature 288:387–388
Bell SC, Billington WD(1983) Anti fetal alloantibody in the pregnant female. Immunol Rev 75:5–30
Bianchi DW, Flint AF, Pizzimenti MF et al(1990) Isolation of fetal DNA from nucleated erythrocytes in maternal blood. Proc Natl Acad Sci USA 87:3279
Bianchi DW, Stewart JE, Garber MF et al(1991) Possible effect of gestationel age on the detection of fetal nucleated erythrocytes in maternal blood. Prenat Diagn 11:523
Bianchi DW, Mahr A, Zickwolf GK et al(1992) Detection of fetal cells with 47, XY, + 21 karyotype in maternal peripheral blood. Hum Genet 90:368 Bianchi DW, Zickwolf GK, Yih MC et al(1993) Haploid-specific antibodies enhance detection of fetal nucleated erythrocytes in maternal blood. Prenat Diagn 13:293
Billingham RE(1988) Immunobiological aspects of the foeto maternal relationship. In:Lachman P, Peters D(eds) Clinical aspects of immunology, 4th edn. Blackwell, Oxford
Billington WD, Burrows FJ(1986) The rat placenta expresses paternal class I MHC antigens. J Reprod Immunol 9:155–160
Bobe P, Kiger N(1987) Immunogenetic aspects of feto maternal tolerance. Coll INSERM 154:235–247
Bobe P, Doric M, Kinsky RG, Voisin GA(1984) Modulation of mouse anti SRBC response by placental extracts. Cell Immunol. 89:355 - 364
Bobe P, Chaouat G, Stanislavski M, Kiger N(1986) Immunogenetics of spontaneous abortion in mice. II. Anti abortive effects are independent of systemic regulatory mechanisms. Cell Immunol 98:577–586
Breyere EJ, Barret MK(1976) Pregnancy induced hypo responsiveness to paternal alloantigens. II. Factors affecting altered expression of immunity in parous rats. Transplantation 34:258–263
Bulmer JD, Ritson A(1988) The decidua in early pregnancy. In:Beard RW, Sharp F(eds) Early pregnancy loss, mechanisms and treatment. 18th RCOG study group. Royal College of Obstetricians and Gynaecologists, London, pp 171–181
Bruce Chwatt LJ(1983) Malaria and pregnancy. Br Med J 286:1457
Bruch JF, Metezeau P, Garcia-fonknechten N et al(1991) Trophoblast-like cells sorted from peripheral blood using flow cytometry:a multiparametric study involving transmission electron microscopy and foetal DNA amplification. Prenat Diagn 11:787
Canepa S(1985) Properietes immunologiques in vitro de surnageants de cultures de choriocarcinomes humains. DERBH University, Paris
Chandler P, Benjamin D, Simpson E(1980) Tolerance to H-Y antigens. In:Fougereau M, Dausset J(eds) 4th International Congress of Immunology, Paris 1980. Book of abstracts. Abstract 04 08 05
Chaouat G(1986) Placental infiltration of resorbing CBA x DBA/s embryos. J Reprod Immunol Suppl p 134
Chaouat G(1995) Low doses of LPS synergises with inflammatory cytokines in induction of murine resorbtions or labour. Alloimmunisation can prevent the abortifacient effects, but not the induction of pretern delivery. Cell Immunol 157:328–340
Chaouat G, Chaffaux S(1981) Induction by placental extracts of suppressor cells of the graft vs. host reaction. Am J Reprod Immunol 6(3):107–112
Chaouat G, Voisin GA(1979) Regulatory T cell subpopulations in pregnancy. I. Evidence for suppressive activity of the early phase of MLR J Immunol 122:1383–1388
Chaouat G, Voisin GA(1980) Regulatory T cells subpopulations in pregnancy. II. Evidence for suppressive activity of the late phase of MLR Immunology 39:239
Chaouat G, Voisin GA(1981a) Regulatory T cells in pregnancy. III. Evidence for the involvement of two T cell subsets. Immunology 44:393–399
Chaouat G, Voisin GA(1981b) Regulatory T cells in pregnancy. IV. Genetic characteristics and mode of action of early MLR suppressive population J Immunol 127:1335–1336
Chaouat G, Voisin GA(1981c) Regulatory T cells in pregnancy. V. Allopregnancy induced T cell suppressor factor is H-2 restricted and bears la determinants. Cell Immunol 62:186–195
Chaouat G, Voisin GA(1982) Regulatory T cells in pregnancy. VI. Evidence for T cell suppression of CTL generation. Cell Immunol 68:668–322
Chaouat G, Voisin GA, Daeron M, Kanellopoulos J(1977) Anticorps facilitants et cellules suppressives dans la reaction immunitaire maternelle anti-foetale. Ann Immunol(Paris) 128:21–24
Chaouat G, Voisin GA, Escalier D, Robert P(1979) Facilitation reaction(enchancing antibodies and suppressor conceptus. Clin Exp Immunol 35:13–24
Chaouat G, Chaffaux S, Voisin GA(1980a) Immuno-active products of placenta I. J Reprod Immunol 2:127–136
Chaouat G, Chaffaux S, Monnot P, Hoffmann M(1980b) Regulation of maternal cellular immunity to the conceptus. Am J Reprod Immunol 1:18
Chaouat G, Kiger N, Wegmann TG(1983) Vaccination against spontaneous abortion in mice. J Reprod Immunol 5:389–392
Chaouat G, Kolb JP, Kiger N, Stanislawski M, Wegmann TG(1985) Immunological concomitants of vaccination against abortion in mice. J Immunol 134:1594
Chaouat G, Lankar D, Kolb JP, Clark DA(1987) G.2 modeles d’ avortements d’ origine immunitaire chez la souris de laboratoire:mecanismes abortifs, modalites et mecanismes du traitement par rimmunisation contre un male relie ou non relie suivant les differences antigeniques pere-mere. In:Chaouat G(ed) Immunologic de la relation feto-maternelle. Libbey, Paris, pp 243–255
Chaouat G, Menu E, Athanassakis I, Wegmann TG(1988a) Maternal T cells regulate placental size and fetal survival. Reg Immunol 1:143
Chaouat G, Clark DA, Wegmann TG(1988b) Immunogenetic studies of spontaneous abortion in mice. I. Preimmunisation of the mother with allogeneic spleen cells. J Immunol 134:2966–2972
Chaouat G, Clark DA, Wegmann TG(1988c) Genetics aspects of the CBA/J x DBA/2 J and B10 x B10. A models of murine spontaneous abortions and prevention by leukocyte immunisation. In:Allen WR, Clark DA, Gill TJ III, Mowbray JF, Robertson WR(eds) Early Pregnancy loss. Mechanisms and treatment. RCOG Press 89–105
Chaouat G, Menu E, Kinsky R, Dy M, Minkowski M, Delage G, Ming Nguy Thang, Clark DA, Wegmann TG, Szekeres Bartho J(1990a) Lymphokines and non specific cellular lytic effectors at the fetomaternal interface affect placental size and survival. In:Mettler L, Billington WD(eds) Reproductive immunology1989. 4th International Congress of Reproductive Immunology. Elsevier, Amsterdam, pp 283–290
Chaouat G, Menu E, Hoffman M, Dy M, Minkowski M, Clark DA, Wegmann TG(1990b) Lymphokines at the feto maternal interface affect fetal size and survival. Coll INSERM 199:133
Chaouat G, Menu E, Dy M, Minkowski M, Clark DA, Wegmann TG(1990c) Control of fetal survival in CBA x DBA/2 mice by lymphokine therapy. J Fertil Steril 89:447–458
Chaouat G, Menu E, Wegmann TG(1991a) Role des lymphokines de la famille du CSF, et du TNF, de l’interféron gamma, et de I’IL-2 sur la survie fetale et la croissance placentaire étudièes in vivo dans 2 modeles d’avortements immunitaires spontanes murins. In:Chaouat G, Mowbray J(eds) Biologie cellulaire et moleculaire de la relation materno fetale. Libbey, Paris, pp 91–101
Chaouat G, Menu E, David F, Szekeres Bartho J, Kinsky R, Dang DC, Kapovic M, Ropert S, Wegmann TG(1991b) Lymphokines, cytokines and immunoregulators involved in pregnancy success or perinatal AIDS. Periodicum Biol 93(l):49–54
Chaouat G, Menu E, Djian V, Delage G, Kinsky R, Assal-meliani A, Frydman R, Martal J(1993a) Lymphokines, cytokines, MHC allorecognition and successful early and late pregnancy. In:Dondero F, Lenzi D(eds) 5th International Congress on Reproductive Immunology. Serono symposia Raven, New York, p 107
Chaouat G, Menu E, David F, Djian V, Kinsky R(1983b) Reproductive immunology 1989–1992:some important recent advances about feto maternal relationship. In:Gergely J(ed) Progress in immunology 8. Springer, Berlin Heidelberg New York, p 825
Chaouat G, Menu E, Djian V, Delage G, Kinsky R, Assal-meliani A, Frydman R, Martal J(1993c) Lymphokines, cytokines, MHC allorecognition and successful early and late pregnancy. In:Dondero F, Lenzi D(eds) 5th International Congress on Reproductive Immunology. Serono symposia Raven, New York, p 107
Chaouat G, Menue E, Lelaidier C, Delage G, Moreauj F, Assal Meliani A, Djian V, Ropert S, David FJE, Wegmann TG, Lin Hui, Raghupathy R, Martal J, Frydman R(1994) Cytokines and immuno endocrine network as determinants of early pregnancy success or failure and in parturition. In:Mori T, Aono T, Tominaga T, Hiroi M(eds) Perspectives in assisted reproduction. Ares, Rome pp 227–235(serono symposia)
Chaouat G, Assal meliani A, Martal J, Raghupathy R, Elliotj, Mossmann T, Wegmann TG(1995a) IL- 10 prevents inflammatory cytokine-mediated fetal death and is inducible by tau interferon. J immunol 154(9):4261–4268
Chaouat G, Menu E, De smedt D, Khrishnan L, Lin Hui, Assal Meliani A, Martal J, Raghupathy R, Wegmann TG(19956) The emerging role of IL-10 in pregnancy. Am J Reprod Immunol 35:325–329
Chattergee-Hasrouni S, Lala PK(1982) Localisation of paternal H-2 antigens on murine trophoblast cells in vivo. J Exp Med 155:1679–1688
Chavez DJ, Maclntyre J A, Colliver J A, Page faulk WP(1987) Allogeneic matings and immunisation have different effects on nulliparous and multiparous mice. J Immunol 139(1):85–91
Chernishov VP, Sluvkin II, Bondarenko GI(1993) Phenotypic characterisation of CD7 +, CD3+ and CD8 + lymphocytes from 1st trimester human decidua using two colour flow cyto fluorometry. Am J Reprod Immunol 295:17–21
Clark DA(1985) Maternal immune response to the fetus. Eos Rev Immunol Immunofarmacol 2:114–117
Clark DA(1995) Maternal aggression against placenta? Am J Reprod Immunol 31(4):205–207
Clark DA, McDermott M, Sczewzuk MR(1980) Impairment of host versus graft reaction in pregnant mice. II. Selective suppression of cytotoxic cell generation correlates with soluble suppressor activity and successful allogeneic pregnancy. Cell Immunol 52:106–118
Clark DA, Croy BA, Rossant J, Chaouat G(1986a) Immune presensitisation and local intrauterine defences as determinants of success or failure of murine interspecies pregnancies. J Reprod Fertility 77:633–643
Clark DA, Chaput A, Tutton B(1986b) Active suppression of host versus graft reaction in pregnant mice. VII. Spontaneous abortion of CBA x DBA/2 foetuses in the uterus of CBA/J mice correlates with deficient no-T
suppressor cell activity. J Immunol 136:1668–1771
Clark DA, Banwatt D, Chaouat G(1983) Stress triggered abortion in mice is prevented by alloimmunisation. Am J Reprod Immunol 29(3):141–148
Clark DA, Chaouat G, Mogil R, Wegmann TG(1994) Prevention of spontaneous abortion in DBA/2 mated CBA/J mice by GM CSF involves CD8 + T cell dependent suppression of natural effector cells cytotoxicity against trophoblast target cells. Cell Immunol 154(1):143–153
Cochet M, Casrouge A, Dumont AM, Transy C, Baleux F, Lee Maloy W, Coligan John E, Cazenave PA, Kourilsky P(1989) A new cell surface molecule closely related to mouse class I transplantation antigens. Eur J Immunol. 19:1927–1931
Croy BA, Rossant J, Clark DA(1985) Effects of alterations in the immunocompetent status of Mus Musculus females on the survival of transferred Mus caroli embryos. J. Reprod. Fertil 74:479–489
De Fougerolles R, Baines M(1988) Modulation of natural killer activity influences resorption rates in CBA x DBA/2 matings. J Reprod Immunol 11(2):147
De Fougerolles R, Baines M(1988) Modulation of natural killer activity influences resorption rates in CBA x DBA/2 matings. J Reprod Immunol 11(2):147
Delassus S, Countinho GS, Saucier S, Darche S, Kourilky P(1994) Differential cytokine expression in maternal blood and placenta during murine gestation. J Immunol 152:2411–2420
Dosne Pasqualini C, Matusevitch R(1980) Induction of runting by pretreatment of the mother with paternal tumor antigens. In:Fougerean M, Paussel J(eds) 4th International Congress of Immunology, Abstract 165.11. Société Franéaise d’Immunologie
Douglas GW, Thomas L, Carr M et al(1959) Trophoblast in the circulating blood during pregnancy. Am J Obstet Gynecol 78:960
Dresser DW(1991) The potentiating effect of pregnancy on humoral immune response of mice. J Reprod Immunol 20:253
Due HT, Masse A, Bobe P, Kinsley RG, Voisin GA(1986) Deviation of humoral and cellular alloimmune reactions by placental extracts. J Reprod Immunol 7:27–39
Edelman P(1983) Cytotoxicity maternelle anti paternelle et avortement repetition. In:Edelmann P, Sureau C(eds) Immunologic de la reproduction humaine. Sandoz, Basel
Ellis SA(1990) HLA-G:at the interface. Am J Reprod Immunol 23:84–86
Ellis SA, Sargent IL, Redman CWG, McMichael AJ(1986) Evidence for a novel LA antigen found on human extravillous trophoblast and choriocarcinoma cell line. Immunology 59:595–601
Engleman EG, McMichael A J, McDevitt HO(1978) Suppression of the mixed lymphocyte reaction in man by a soluble T cell factor:specificity of the factor for both the responder and the stimulator, J Exp Med 147:1037–1045
Fabris N, Painatanelli L, Muzzioli M(1977) Differential effects of pregnancy and gestagens on cell mediated immunity Clin Exp Immunol 28:306
Gendron RL, Baines M(1988) Infiltrating decidual natural killer cells are associated with spontaneous abortion in mice. Cell Immunol 113:261
Gendron RL, Nestel FP, Lapp WS, Baines MG(1989) Lipopolysaccharide induced fetal resorbtion involves embryo associated production of tumor necrosis factor 7th International Congress on Immunology Berlin Abstr 118/017
Genetet N(1988) Immunite cellulaire maternelle en grossesse. Communication la Societe Franaise d’Etude de la Fertilite et de la Sterilite, Paris. PhD thesis, University of Rennes
Genetet N, Genetet B, Fauchet R(1982) Allogeneic responses in, vivo induced by feto maternal alloimmunisation. Am J Reprod Immunol 2:90
Genetet N, Genetet B, Fauchet R(1982) Allogeneic responses in, vivo induced by feto maternal alloimmunisation. Am J Reprod Immunol 2:90
Gottesman S, Stutman O(1980a) Cellular immunity during pregnancy. Proliferative and cytotoxic activity of para aortic lymph nodes. Am J Reprod Immunol 1:10
Gottesman S, Stutman O(1980b) Cellular immunity during pregnancy. II. Response to T and B cell mitogens. Am J Reprod Immunol 1:57
Hamaoka T, Majusaki N, Itoh S, Tsuji Y, Izumi Y, Fujiwarah, Ono S(1983) Human trophoblast and tumor cell derived immunoregulatory factor. In:Billington WD, Isojima S(eds) Reproductive immunology III. Elsevier, Amsterdam, pp 103–107
Hamaoka T, Itoh K, Izumi Y, Ono S(1987) Selective Suppression of class II MHC-directed responses by soluble factors. In:Gill TJ, Wegmann TG(eds) Immunoregulation and fetal survival. Oxford University Press Oxford, pp 169–180
Hart CA(1988) Pregnancy and host resistance. Clin Immunol Allergy Allergy 2:735
Herzenberg LA, Bianchi DW, Schroder J et al(1979) Fetal cells in the blood of pregnant women:detection and enrichment by fluorescence-activated cell sorting. Proc Natl Acad Sci USA 76:1453
Heyhorne K, Fu YX, Nelson A, Farr A, O’Brien R, Born W(1994) Recognition of trophoblast by gamma delta T cells. J Immunol 153:2918–2926
Hogarth PJ(1982) Immunological aspects of mammalian reproduction. Blackie, Glasgow
Holland D, Bretscher P, Russel AS(1984) Immunologic and inflammatory responses during pregnancy. Clin Lab Immunol 14:177
Hoversland RC, Beaman KD(1990) Embryo implantation associated with increase in T cell suppressor factor in the uterus and spleen of mice. J Reprod Fertil 88:135–139
Hoversland RC, Beaman KD(1991) The lack of effect of a monoclonal antibody against murine T cell suppressor factor on murine embryo development in vitro. Am J Reprod Immunol 26:84–88
Jenkinson EJ, Owen V(1980) Ontogeny and distribution of major histocompatibility complex(MHC) antigens on mouse placental trophoblast. J Reprod Immunol 2:173–181
Kachkache M, Acker GM, Chaouat G, Noun A, Garabedian M(1991) Hormonal and local factors control the immunohistochemical distribution of immunocytes in the rat uterus before conceptus implantation:effects of ovariectomy, fallopian tube section and RU 486 injection. Biol Reprod 45:860
Kaliss N, Dagg NK(1964) Immune responses engendered in mice by multiparity. Transplantation 2:415–420
Kanbour A, Hong Nerg HO, Misra DN, MacPherson T, Kunz HW, Gill TJ(1987) Differential expression of MHC class I antigens on the placenta of the rat. A mechanism for the survival of the fetal allograft J Exp Med 166:1861
Kanbour-Sharir A, Zhang X, Rouleau A, Armstrong DT, Kunz HW, MacPherson TA, Gill TJ(1990) Gene imprinting and major histocompatibility complex class I antigen expression in the rat placenta. Proc Natl Acad Sci USA 87:444–448
Khrihsnan L, Menu E, Chaouat G, Talwar GP, Raghupathy R(1991) In vitro and in vivo immunosuppressive effects of supernatants from human choriocarcinoma. Cell Immunol 138:313–326
Kinsky R, Delage G, Rosin N, Thang MN, Hoffmann M, Chaouat G(1990) A murine model of NK cell mediated resorption. Am J Reprod Immunol 23:73
Kinsky R, Menu E, Delage G, Rosin N, Thang MN, Hoffmann M, Kapovic M, Jaulin C, Kourilsky P, Wegmann TJ, Chaouat G(1991) Murine NK cell mediated resorption and prevention by maternal alloimmunisation. In:chaouat G, Howbray J(eds) Biologie cellulaire et moleculaire de la relation materno fetale. Libbey, Paris, pp 245–261
Kinsky R, Kapovic M, Menu E, Jaulin C, Kourilksy P, Wegmann TG, Thank MN, Chaouat G(1993) The role of defined major histocompatibility antigens in preventing fetal death. In:Chaouat G(ed) The Immunology of pregnancy. CRC, Boca Ratou, pp 47–61
Kovatts S, Main EK, Libbrach C, Stublebline M, Fischer SJ, De Mars R(1990) A class I antigen, HLA-G, expressed in human trophoblasts. Science 248:220–223
Kovatts S, Librach C, Main EK, Sondel PM, Fischer SJ, De Mars R(1991) The role of non classical MHC class I on human trophoblast. In:Chaouat G, Mowbray J(eds) Biologie cellulaire et moleculaire de la relation materno fetale Libbey, Paris, pp 13–21, 41–51
Kovitavong T, Dossetor JB(1981) Suppressor T cells in rat pregnancy. In:Gill TG, Wegmann TG(eds) First Banff meeting. Banff, University of Alberta, Edmonton Kurago ZH, Smith KD, Lutz CT(1995) NK cells recognition of MHC class I:NK cells are sensitive to peptide binding groove and surface alpha helical mutations that affect T cells. J Immunol 154(6):2631–2642
Labarrere C, Faulk WP(1995) Maternal cells in chorionic villi from placentae of normal and abnormal human pregnancies. Am J Reprod Immunol 33(l):54–60
Laesen B, Galask RP(1978) Host parasite interactions during pregnancy. Obstet Gynaecol surv 33:297
Lanman JT, Dinenstein J, Fikring S(1962) Homograft immunity in pregnancy. Lack of harm to foetus from sensitisation of the mother. Ann N Y Acad Sci 99:706–718
Lee CK, Ghoshal K, Beaman KD(1990) Cloning of a cDNA coding for a T cell molecule with putative immunoregulatory role. Mol Immunol 27:1134–1137
Lelaidier C(1995) Early embryo development, uterus preparation, and role of cytokines in implementation INSERM pp 182–198
Liburd J, Dossetor JB(1982) Suppressor cells in human pregnancy. In:Gill TG III, Wegmann TG(eds) First Banff meeting. Banff, University of Alberta, Edmonton
Lin H, Mossman TR, Guilbert L, Tuntipopipat S, Wegmann TG(1993) Synthesis of T helper -2 cytokines at the maternal fetal interface. J Immunol 151:4562
Luft, BJ, Remington JS(1984) Effect of pregnancy on augmentation of natural killer activity by Corynebacterium parvum and toxoplasma Gondii J Immunol 132:2375
MacMaster MT, Newton RC, Sudhanski KD, Andrews GK(1992) Activation and distribution of inflammatory
cells in the mouse uterus during the preimplantation period. J Immunol 148:1699–1711
Mattson R(1982) Increase in the number of plaque forming cells with length of gestation in untreated pregnant mice. Dev Comp Immunol 6:339–348
Mattson R, Holmdal R(1987) Maintained allopregnancy in rats depleted of T cytotoxic/suppressor cells by OX8 monoclonal antibody treatment. J Reprod Immunol 12:23–24 Mattson R, Mattson
A, Sulila P(1985) Allogeneic pregnancy in B cell depleted CBA/Ca mice. Effects on fetal survival and maternal lymphoid organs. Dev Comp Immunol 9:709–717
Mattsson R, Holmdahl R, Scheynius A, Bernadotte F, Mattsson L(1989) Allopregnancy in mice treated with recombinant rat interferon-gamma. J Reprod Immunol Suppl 151
Mattson R, Holmdahl R, Scheynius A, Bernadotte F, Mattsson L(1991) Placental MHC class I antigen expression is induced in mice following in vivo treatment with recombinant interferon gamma. J Reprod Immunol 19(2):115–129
Medawar PB(1953) Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol 7:320–338
Meinecke Tillmann S, Meinecke B(1994) Experimental chimeras - removal of reproductive barrier between sheep and goat. Nature 307:637–638
Menu E, Chaouat G, Kinsky R, Delage G, Kapovic M, Thang MN, Jaulin C, Kourilsky P, Wegmann TG(1995) Alloimmunisation against well defined polymorphic major histocompatibility or class I MHC transfected L cells can prevent POLY IC induced fetal death in mice. Am J Reprod Immunol 33:200–312
Mitchison NA(1953) The effect on the offspring of maternal immunisation in mice. J Genet 5:406–411
Monnot P, Chaouat G(1984) Systemic active suppression is not necessary for successful allopregnancy. Am J Reprod Immunol 6:5–8
Mori T, Nishikawa T, Saito S, Enomotop M, Ito A, Kurai K, Shimoayama T, Iehijo M, Narita N(1983) T cell receptors are expressed but down regulated on intra decidual T lymphocytes. Am J Reprod Immunol 29(1):1–5
Nelson K, Cory J, Hellstrom I, Hellsstrom K(1980) A suppressor T cell hybridoma. Proc Natl Acad Sci USA 7:2866
Noun A, Acker G, Chaouat G, Antoine JC, Garabedian M(1989) Macrophages and T lymphocyte bearing antigens bearing cells in the uterus before and during ovum implantation in the rat. Clin Exp Immunol 78:434–438
O’Hearn M, Hilard F(1981) Pregnancy induced alteration in graft versus host reactions of uterine and peripheral lymph nodes during towards fetal alloantigens. Transplantation 32:389
Paldi A, D’Auriol L, Misrahi M, Bakos A, Chaouat G, Szekeres Bartho J(1994) Expression of the gene coding for the progesterone receptor in activated human lymphocytes. Endocr J 2:317–319
Parand M, Chedid L(1964) Protective effects of chlorpromazine against endotoxin induced abortion. Proc Soc Exp Biol Med 116:906–915
Pa via CS, Stites DP(1979) Humoral and cellular immunity during pregnancy. J Immunol 123:2194–220
Peck AB, Bach FB(1973) A miniaturised mouse mixed lymphocyte culture in serum free and mouse serum supplemented media. J Immunol Methods 3:147
Reagan L, Raude PR(1987) Is paternal cytotoxic antibody a valid marker for the treatment of recurrent abortion. Lancet 2:280
Redline RW, Lu CY(1988) Specific defects in the anti listerial immune response in discrete regions of the murine uterus and placenta account for the susceptibility to infection. J Immunol 140:3497
Redline CW, Lu CY(1990) Localisation of fetal MHC antigens and maternal leukocytes in murine placenta. Lab Invest 61:27–38
Reznikoff-Etievant MF, Simonney N, Janaud A, Darbois Y, Netter A(1985) Treatment of recurrent spontaneous abortions by immunisation with paternal leukocytes. Lancet 1:1398
Rich SS, Rich RR(1976) Regulatory mechanisms in cell mediated immune responses III Region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions. J Exp Med 140:1588
Rodger JC(1985) Lack of requirement for a maternal humoral immune response to establish or maintain a successful allogeneic pregnancy. Transplantation 40:372–375
Rossant J, Mauro VM, Croy BA(1982) Importance of trophoblast genotype for survival of interspecific murine chimeras. J Embryol Exp Morphol 69:141
Schroder J(1975) Transplacental passage of blood cells. J Med Genet 12:230
Singh B, Raghupathy R, Anderson DJ, Wegman TG(1983) The murine placenta as an immunological barrier between the mother and the fetus. In:Wegmann TG, Gill TG III(eds) Immunology of reproduction. Oxford University Press, New York(51st Banff conference)
Smith G(1981) Maternal regulator cells during murine pregnancy. Clin Exp Immunol 44:90–98
Smith JA, Burton RC, Barg M, Mitchell GF(1978) Maternal alloimmunisation in pregnancy. In vitro studies of T cell dependent immunity of paternal alloantigens. Transplantation 25:216
Smith RN, Powell AE(1977) The transfer of pregnancy induced hyporesponsiveness to male skin grafts with thymus dependent spleen cells. J Exp Med 156:899–911
Smith RN, Sternlicht M, Butler M(1982a) The alloantibody response in the allogeneically pregnant rat. I. The primary and secondary antibody response and the detection of Ir gene control. J Immunol 129:771–776
Smith RN, Margolies RT, Butler M(1982b) The alloantibody response in the allogeneically pregnant rat. II. Primary pregnancy induced anti RTI-A antibodies are not as cross reactive as secondary pregnancy induced or conventionally raised alloantibodies. J Immunol 129:777–782
Stern MM, Kahan MC(1980) Mixed lymphocyte reactivity and anti H-2 cytotoxicity during murine pregnancy. In:Fougereau M, Dausset J(eds) 4 th International Congress of Immunology, Paris 1980. Book of abstracts. Abstract 16. 5. 32. Societe Frangaise dTmmunologie, Paris
Szekeres Bartho J, Chaouat G(1990) A T cell derived progesterone induced blocking factor correct resorbtions in a murine abortion system. Am J Reprod Immunol 23:26–29
Szekeres Bartho J, Kilar F, Falkay G, Csernu V, Torok A, Pacsa AS(1985) Progesterone treated lymphocytes release a substance inhibiting cytotoxicity and prostaglandin synthesis. Am J Reprod Immunol 9:15
Szekeres Bartho J, Reznikoff-Etievant M, Varga P, Pichon MF, Vargo Z, Chaouat G(1989a) Lymphocytic progesterone receptors in human pregnancy. J Reprod Immunol 16:239
Szekeres Bartho J, Autran B, Debre P, Andreu G, Denver L, Blot P, Chaouat G(1989b) Immunoregulatory effects of a suppressor factor from healthy pregnant women’s lymphocytes after progesterone induction. Cell Immunol 122:281
Szekeres Bartho J, Szekeres G, Debre P, Autran B, Chaouat G(1990) Reactivity of lymphocytes to a progesterone receptor specific monoclonal antibody. Cell Immunol 125:273
Szekeres Bartho J, Kinsky R, Kapovic M, Chaouat G, Varga P, Csizar T(1993) The role of immuno endocrine mechanisms in pregnancy termination. In:Szekeres Bartho J(ed) Reproductive immunology. Raven, New York, pp 217–221(Serono symposium 97 )
Tafuri A, Alferink J, Moler P, Hammerling G, Arnold B(1995) T cell awareness of paternal alloantigens during pregnancy. Science 270:630 - 633
Tamaki J, Arimura Y, Koda S, Fujimoto S, Fujino T, Wakisaka A, Kaminuma M(1993) Heterogeneity of HLA-G genes identified by polymerase chain reaction/single strand conformational polymorphism(PCR/SSCP). Microbiol Immunol 37:633
Tangri S, Raghupathy R(1993) Expression of cytokines in placenta of mice undergoing immunologically mediated fetal resorption. Biol Reprod 49(4):840–850
Tangri S, Wegmann TG, Lin H, Raghupathy R(1994) Maternal anti placental activity in natural, immunologically mediated fetal resorption. J Immunol 152:4903
Tartakowsky B, Gorelik E(1986a) Murine models of immunologically induced abortions. Coll INSERM 154:399
Tartakowsky B, Gorelik E(1986b) Murine abortion models. In:Wegmann TG, Gill TJ(eds) The placenta and the survival of the fetal allograft. Oxford University Press,( Reproductive immunology II) Oxford
Tartakowsky B, Gorelik E(1988) Immunisation with asyngeneic regressor tumor causes resorptions in allopregnant mice. J Reprod Immunol 13(2):113
Tezabwala BU, Jonhson PM, Rees RC(1989) Inhibition of pregnancy viability in mice following IL-2 administration. Immunology 67:115–120
Toder V Shomer B(1990) The role of lymphokines in pregnancy. Immunol Allergy Clin North Am 10(l):65–77
Toder V, Shepelovitch J, Carp H, Altaraz H, Strassburger D(1991) Cytokine function in immunopotentiated females. In:Chaouat G, Mowbray J(eds) Biologie cellulaire et moleulaire de la relation materno fetale. Libbey, Paris, 263
Van der Ven K, Ober C(1993) HLA-G polymorphism in African Americans. J Immunol 153:5628
Vanzoorn CJ(1986) Cortisol and malaria immunity during pregnancy. PhD thesis, University of Nijmegen
Vleughels AC(1990) Cerebral malaria immunity and pregnancy. PhD thesis, University of Nijmegen
Voisin GA(1962) Immunological tolerance to living cells. Homologus disease and immunological facilitation(enhancement phenomenon). A working hypothesis allowing a unified concept. In:Hasek M, Lengerova A, Vostiskova M(eds) Symposium on mechanism of immunological tolerance. Czechoslovakian Academy of Science, Prague, pp 435–455
Voisin GA(1971) Immunological facilitation. A broadening of the concept of the enhancement phe¬nomenon Prog Allergy 15:328–485
Voisin G, Chaouat GA(1974) Demonstration, nature and properties of antibodies eluted from the placenta and directed against paternal antigens. J Reprod Fertili Suppl 21:89
Voisin JE, Monnot P, Voisin GA(1986) Maternal alloimmune reactions towards the conceptus and GVHR. I. Priming for antipaternal GVHR by gestation. J Reprod Immunol 9:73–81
Wegmann TG, Waters CA, Drell DW, Carlson GA(1979a) Pregnant mice are not primed but can be primed to fetal alio antigens. Proc Natl Acad Sci USA 76:2410–2412
Wegmann TG, Mossman TR, Carlson G, Olingk O, Singh B(1979b) The ability of the murine placenta to absorb monoclonal anti fetal H-2 K antibody from the maternal circulation. J Immunol 122:270–277
Wegmann TG(1984) Fetal protection against abortion:is it immunosuppression or immunostimulation? Ann Immunol(Paris) 135 D:309
Wegmann TG, Athanassakis I, Mogil R, Chaouat G(1988) Placental immunotrophism. Maternal T cells contribute to the growth and survival of the fetal allograft. In:proceedings VI World Congress on Human Reproduction, Elsevier, Amsterdam
Wegmann TG, Athanassakis I, Guilbert L, Branch D, Dy M, Menu E, Chaouat G(1989) The role of M- CSF and GM-CSF in fostering placental growth, fetal growth, and fetal survival. Transplant Proc 21(11):89, 566–569
Wegmann TG, Athanassakis I, Guilbert L, Branch D, Dy M, Menu E, Chaouat G(1991) Maternal T cell reactivity as a positive determinant of placental growth and fetal survival. In:Belissarion R, Mijezewski G(eds) Transplantation disorders. Prenatal detection, treatment and management. Liss, New York, pp 69–76
Wegmann TG, Lin H, Guilbert L, Mossman TH(1993) Bi-directional cytokines interactions in the materno fetal relationship:successful allopregnancy is a Th2 phenomenon. Immunol Today 14:353– 355
Weidanz WP(1982) Malaria and alterations in immune reactivity. Br Med Bull 38:167
Whaley AE, Caroll RS, Nephew KP, Imakawa K(1991a) Molecular cloning of unique interferons from human placenta. In workshop of annual meeting of the International Society for Interferon Research. Nice(France). J Interferon Res 11 [Suppl](abstract)
Whaley AE, Caroll RS, Imakawa K(1991b) Cloning and analysis of a gene encoding ovine interferon a-II. Gene 106:281–282
Yokoyama M, Sano M, Sonanda K, Nnozaki M, Nakamura G, Nakano H(1995) Cytotoxic cells directed against human placental cells detected in human habitual abortion by an in vitro terminal labelling assay? Am J Reprod Immunol 31(4):197–205
Zagury D, Chaouat G, Morgan DA, Voisin GA(1979) Participation aux mecanismes de suppression de la reaction immunitaire de cellules pouvoir cytotoxique en presence de lectines. CR Acad Sci [D](Paris) 288:1343–1346
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Chaouat, G., Menu, E. (1997). Maternal T Cell Reactivity in Pregnancy?. In: Olding, L.B. (eds) Reproductive Immunology. Current Topics in Microbiology and Immunology, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60614-4_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-60614-4_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64475-7
Online ISBN: 978-3-642-60614-4
eBook Packages: Springer Book Archive