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The Adenine Nucleotide Translocator: A Major Autoantigen in Myocarditis and Dilated Cardiomyopathy

  • Conference paper
The Role of Immune Mechanisms in Cardiovascular Disease

  • 72 Accesses

Abstract

Current concepts of autoimmunity emphasize the significance of antibodies in the development and maintenance of autoimmune disorders. However, it is difficult to show that a given autoantibody is an essential component of a pathological mechanism which leads to tissue damage and organ dysfunction. Beside contributing to an understanding of the pathogenesis, a precise characterization of the antibodies involved in the autoimmunological process may have diagnostic and prognostic value.

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References

  1. Schultheiss H-P, Schwimmbeck P (1986) Autoantibodies to the adenine nucleotide translocator (ANT) in myocarditis (MC): prevalence, clinical correlates and diagnostic value. Circulation 74 [Suppl 2]: 142

    Google Scholar 

  2. Schultheiss H-P (1986) The significance of autoantibodies against the ADP/ATP carrier for the pathogenesis of myocarditis and dilated cardiomyopathy: clinical and experimental data. Springer Semin Immunopathol 11: 15–30.

    Google Scholar 

  3. Schultheiss H-P, Schulze K, Kühl U, Ulrich G, Klingenberg M (1987) The ADP/ATP carrier as an mitochondrial autoantigen: facts and perspectives. Ann NY Acad Sci 488: 44–64

    Article  Google Scholar 

  4. Schultheiss HP, Kühl U, Schauer R, Schulze K, Kemkes B, Becker BF (1988) Antibodies against the ADP/ATP carrier alter myocardial function by disturbing cellular energy metabolism. In: Schultheiss HP (ed) New concepts in viral heart disease. Springer, Berlin Heidelberg New York, pp 243–258

    Google Scholar 

  5. Schulze K, Becker BF, Schauer R, Schultheiss HP (1990) Antibodies to ADP-ATP carrier-an autoantigen in myocarditis and dilated cardiomyopathy — impair cardiac function. Circulation 81: 959–969

    Article  PubMed  CAS  Google Scholar 

  6. Klingenberg M (1985) The ADP/ATP carrier in mitochondrial membranes. In: Martonosi AN (ed) The enzymes of biological membranes, vol 4. Plenum, New York, pp 511–533

    Google Scholar 

  7. Klingenberg M, Heldt HW (1982) The ADP/ATP translocation in mitochondria and its role in intracellular compartmentation. In: Sies H (ed) Metabolic compartmentation. Academic, London, pp 101–122

    Google Scholar 

  8. Klingenberg M (1980) The ADP/ATP carrier translocation in mitochondria: a membrane potential controlled transport. J Membr Biol 56: 97

    Article  PubMed  CAS  Google Scholar 

  9. Schultheiss HP (1990) Effect on the myocardial energy metabolism of angiotensin-con-verting enzyme inhibition in chronic heart failure. Am J Cardiol 65: 74G–81G

    Article  PubMed  CAS  Google Scholar 

  10. Hardy CJ, Weiss RG, Bottomley PA, Gerstenblith G (1991) Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy: Am Heart J 122: 795–801

    Article  PubMed  CAS  Google Scholar 

  11. Neubauer S, Krahe T, Schindler R, Horn M, Hillenbrand H, Entzeroth C, Mader H, Kromer EP, Riegger GAJ, Lackner K, Ertl G (1992) 31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease: altered cardiac high-energy phosphate metabolism in heart failure. Circulation 86: 1810–1818

    PubMed  CAS  Google Scholar 

  12. Schultheiss HP (1987) The mitochondrium as an autoantigen in inflammatory heart disease. Eur Heart J 8[Suppl]: 203–210

    CAS  Google Scholar 

  13. Schultheiss HP, Bolte HD (1985) Immunological analysis of autoantibodies against the adenine nucleotide translocator in dialted cardiomyopathy. J Mol Cell Cardiol 17: 603–617

    Article  PubMed  CAS  Google Scholar 

  14. Schultheiss HP, Klingenberg M (1984) Immunochemical characterization of the adenine nucleotide translocator: organ-and conformation-specifity. Eur J Biochem 143: 599–605

    Article  PubMed  CAS  Google Scholar 

  15. Schultheiss HP, Klingenberg M (1985) Immunoelectrophoretic characterization of the ADP/ATP carrier from heart, kidney and liver. Arch Biochem Biophys 239: 273–279

    Article  PubMed  CAS  Google Scholar 

  16. Ku DF, Kagan J, Chen ST, Chang CD, Basergo R, Wurzel J (1990) The human fibroblast adenine nucleotide translocator gene. J Biol Chem 265: 16060–16063

    PubMed  CAS  Google Scholar 

  17. Cozens AL, Runswick MJ, Walker JE (1989) DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J Mol Biol 206: 261–280

    Article  PubMed  CAS  Google Scholar 

  18. Gawaz M, Douglas MG, Klingenberg M (1990) Structure-function studies of adenine nucleotide transport in mitochondria. II. Biochemical analysis of distinct AACI and AAC2 in yeast. J Biol Chem 265: 14202–14208

    PubMed  CAS  Google Scholar 

  19. Oldstone MBA, Dyrberg TI, Fujinami R (1986) Mimicry by virus of host molecules: implications for autoimmune disease. Prog Immunol 6: 787–795

    Google Scholar 

  20. Schwimmbeck PL, Schultheiss H-P, Strauer BE (1989) Identification of a main auto-immunogenic epitope of the adenine nucleotide translocator which cross-reacts with Coxsackie B3 virus: use in the diagnosis of myocarditis and dilative cardiomyopathy. Circulation 80 [Suppl II]: 665

    Google Scholar 

  21. Schwimmbeck PL, Schultheiss H-P, Strauer BE, Oldstone MBA (1989) Sharing of antigenic determinants between Coxsackie B3 virus and autoantigens in viral myocarditis and dilative cardiomyopathy. J Am Coll Cardiol 13: 253–25A

    Google Scholar 

  22. Schwimmbeck PL, Schultheiss HP, Strauer BE (1990) Isolation of myocardial autoantibodies using immunoadsorption with synthetic peptides as antigens. Eur Heart J 11 [Suppl]: 280

    Google Scholar 

  23. Zanetti M (1986) New concepts in autoimmunity. Immunol Invest 15: 287

    Article  PubMed  CAS  Google Scholar 

  24. Rose NR, Herskowitz A, Neumann DA, Neu N (1988) Autoimmune myocarditis: a paradigm of post-infection autoimmune disease. Immunol Today 9: 117–119

    Article  PubMed  CAS  Google Scholar 

  25. Archard LC, Freeke AC, Richardson PJ, Meany B, Olson EGJ, Morgan-Capner P, Rose ML, Taylor P, Banner NR, Yacoub MH, Bowles NE (1988) Persistence of enterovirus RNA in dilated cardiomyopathy: a progression from myocarditis. In: Schultheiss H-P (ed) New concepts in viral heart disease. Springer, Berlin Heidelberg New York, pp 349–362

    Google Scholar 

  26. Kandolf A, Kirschner P, Ameis D, Canu A, Erdmann E, Schultheiss H-P, Kemkes B, Hofschneider P (1989) Enteroviral heart disease: diagnosis by in-situ hybridization. In: Schultheiss HP (ed) New concepts in viral heart disease. Springer, Berlin Heidelberg New York, pp 337–348

    Google Scholar 

  27. Editorial (1990) Dilated cardiomyopathy and enteroviruses. Lancet 336: 971–973

    Article  Google Scholar 

  28. Oldstone MBA, Dyrberg TI, Fujinami R (1986) Mimicry by virus of host molecules: implications for autoimmune disease. Prog Immunol 6: 787–795

    Google Scholar 

  29. Izumo S, Nadal-Ginard B, Mandavi V (1988) Protooncogene induction and reprogram-ming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci USA 85: 339–343

    Article  PubMed  CAS  Google Scholar 

  30. Komuro I, Yazaki Y (1993) Control of cardiac gene expression by mechanical stress. Annu Rev Physiol 55: 55–75

    Article  PubMed  CAS  Google Scholar 

  31. Stepien G, Torroni A, Chung AB, Hodge JA, Wallace DC (1992) Differential expression of the adenine nucleotide translocator isoforms in mammalian tissues and during muscle cell differentiation. J Biol Chem 267: 14592–14597

    PubMed  CAS  Google Scholar 

  32. Schultheiss HP, Bolte HD (1985) Immunological analysis of autoantibodies against the adenine translocator in dilated cardiomyopathy. J Mol Cell Cardiol 17: 603–617

    Article  PubMed  CAS  Google Scholar 

  33. Schultheiss HP (1987) The mitochondrion as antigen in inflammatory heart disease. Eur Heart J 8: 23–210

    Google Scholar 

  34. Schultheiss HP, Kühl U, Schauer R, Schulze K, Kemkes B, Becker BF (1988) Antibodies against adenosine di-triphosphate carrier alter myocardial function by disturbing cellular energy metabolism. In: Schultheiss HP (ed) New concepts in viral heart disease. Springer, Berlin Heidelberg New York, pp 243–258

    Google Scholar 

  35. Schulze K, Becker BF, Schultheiss H-P (1989) Antibodies to the ADP/ATP carrier — an autoantigen in myocarditis and dilated cardiomyopathy — penetrate into myocardial cells and disturb energy metabolism in vivo. Circ Res 64: 179–192

    PubMed  CAS  Google Scholar 

  36. Janda I, Herzog V, Kühl U, Schultheiss H-P (1990) Biochemical and immunocytochemical evidence for endocytosis of antibodies against the ADP/ATP carrier — an autoantigen in dilated cardiomyopathy. Circulation 82[Suppl III]: 268

    Google Scholar 

  37. Schultheiss H-P, Kühl U, Janda I, Melzner B, Ulrich G, Morad M (1988): Antibody-mediated enhancement of calcium permeability in cardiac myocytes. J Exp Med 168: 2105–2116

    Article  PubMed  CAS  Google Scholar 

  38. Morad M, Davies NW, Ulrich G, Schultheiss H-P (1988) Antibodies against ADP-ATP carrier enhance Ca2+ current in isolated cardiac myocytes. Am J Physiol 255: H960–H964

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University of Berlin, Hindenburgdamm 32, 12200, Berlin, Germany

    H.-P. Schultheiss, K. Schulze, P. Schwimmbeck & A. Dörner

Authors
  1. H.-P. Schultheiss
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  2. K. Schulze
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  3. P. Schwimmbeck
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  4. A. Dörner
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Editor information

Editors and Affiliations

  1. Abteilung für Kardiologie/Pulmologie, Universitätsklinikum Benjamin Franklin der Freien Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Heinz-Peter Schultheiss  & Peter Schwimmbeck  & 

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© 1997 Springer-Verlag Berlin Heidelberg

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Schultheiss, HP., Schulze, K., Schwimmbeck, P., Dörner, A. (1997). The Adenine Nucleotide Translocator: A Major Autoantigen in Myocarditis and Dilated Cardiomyopathy. In: Schultheiss, HP., Schwimmbeck, P. (eds) The Role of Immune Mechanisms in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60463-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-60463-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61358-9

  • Online ISBN: 978-3-642-60463-8

  • eBook Packages: Springer Book Archive

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