Abstract
The pathogenesis of myocarditis (MC) and dilated cardiomyopathy (DCM) is still poorly understood. It is assumed that an enteroviral infection, for example, by coxsackie B (CB) viruses is initiating the inflammatory process in human MC. This is supported by epidemiological studies showing an increased incidence of viral MC following endemics of CB virus infections (Helin et al. 1968). In addition, the recent demonstration of enteroviral RNA in endomyocardial tissue of patients, suggested a pathophysiological significance of the infection. Using molecular biological methods such as dot-blot analysis, in-situ hybridization or polymerase chain reaction (PCR), enteroviral RNA could be demonstrated in up to 50% of patients with MC and in an almost equally high percentage of cases with DCM (Bowles et al. 1986). However, the percentage of positive samples differs widely between the different studies, possibly due to different probes used for hybridization, differences in the primers utilized for amplification, or contamination with viral RNA, especially in the PCR, thus giving false-positive results.
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© 1997 Springer-Verlag Berlin Heidelberg
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Schwimmbeck, P., Badorff, C., Schulze, K., Schultheiss, HP. (1997). The Significance of T Cell Responses in Human Myocarditis. In: Schultheiss, HP., Schwimmbeck, P. (eds) The Role of Immune Mechanisms in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60463-8_7
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DOI: https://doi.org/10.1007/978-3-642-60463-8_7
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