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The Role of Cytokines in the Pathogenesis of Myocarditis

  • Conference paper
The Role of Immune Mechanisms in Cardiovascular Disease

Abstract

Cytokines are multipurpose low molecular weight “pleotropic” intercellular signaling peptides that are the major mediators of inflammation, cellular growth, cellular transformation, nuclear activation, matrix repair, gene regulation and cell death. They have been best identified with the immune system, to bring about the coordinated response following injury in all tissues (Lange and Schreiner 1994). At low doses, cytokine fine tune the body system for maintenance function. The cytokines regulate host cell function through autocrine (self-regulation) or paracrine (regulation of neighbouring cells) pathways. In cases of severe stimulation, high doses of cytokines are released into the blood stream to produce a potentially endocrine effect. This high level of cytokines may be toxic to target cells. The teleological purpose of this action is to eliminate potentially sources of harm for the organism (such as infected cells), but it ultimately can cause the destruction of the host cell.

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Author information

Authors and Affiliations

  1. General Division, GW1-508, The Toronto Hospital, Toronto, Ontario, M5G 2C4, Canada

    P. Liu

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  1. P. Liu
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Editor information

Editors and Affiliations

  1. Abteilung für Kardiologie/Pulmologie, Universitätsklinikum Benjamin Franklin der Freien Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Heinz-Peter Schultheiss  & Peter Schwimmbeck  & 

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© 1997 Springer-Verlag Berlin Heidelberg

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Liu, P. (1997). The Role of Cytokines in the Pathogenesis of Myocarditis. In: Schultheiss, HP., Schwimmbeck, P. (eds) The Role of Immune Mechanisms in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60463-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-60463-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61358-9

  • Online ISBN: 978-3-642-60463-8

  • eBook Packages: Springer Book Archive

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