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Immunohistochemical Analysis of Inflammatory Heart Disease

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The Role of Immune Mechanisms in Cardiovascular Disease

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Abstract

Cardiomyopathies are diseases of the heart characterized by ventricular dysfunction that is not due to secondary causes such as hypertension, congenital, valvular, coronary, arterial, or pericardial abnormalities. They are described as primary cardiomyopathies if the origin of cardiac dysfunction is unknown, and as secondary or specific cardiomyopathies if the heart is involved by specific infectious, metabolic, neuromuscular or toxic diseases. According to the new definition of the WHO, primary cardiomyopathies are classified as dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy [1].

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References

  1. WHO (1996) Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation 93: 841–842

    Article  Google Scholar 

  2. Zee-Cheng CS, Tsai CC, Palmer DC, Codd JE, Pennington DG, Williams GA (1984) High incidence of myocarditis by endomyocardial biopsy in patients with idiopathic congestive cardiomyopathy. J Am Coll Cardiol 3: 63–70

    Article  PubMed  CAS  Google Scholar 

  3. Steenbergen C, Kolbeck PC, Wolfe JA, Anthony RM, Sanfilippo FP, Jennings RB (1986) Detection of lymphocytes in endomyocardium using immunohistochemical techniques. Relevance to evaluation of endomyocardial biopsies in suspected cases of lymphocytic myocarditis. J Appl Cardiol 1: 63–73

    Google Scholar 

  4. MacArthur CGC, Tarin D, Goodwin JF, Hallidie-Smith KA, (1984) The relationship of myocarditis to dilated cardiomyopathy. Eur Heart J 5: 1023–1035

    PubMed  CAS  Google Scholar 

  5. Kawai C, Matsumori A, Fujiwara H (1987) Myocarditis and dilated cardiomyopathy. Ann Rev Med 38: 221–239

    Article  PubMed  CAS  Google Scholar 

  6. Dec GW Jr, Palacios IF, Fallon JT, Aretz HT, Mills J, Mills DCS, Johnson RA (1985) Active myocarditis in the spectrum of acute dilated cardiomyopathies. N Engl J Med 312: 885–890

    Article  PubMed  Google Scholar 

  7. Shanes JG, Ghali J, Billingham ME, Ferrans VJ, Fenoglio JJ, Edwards WD, Tsai CC, Saffitz JE, Isner J, Furner S, Subramanian R (1987) Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation 75: 401–405

    Article  PubMed  CAS  Google Scholar 

  8. Billingham MB (1987) Acute myocarditis: a diagnostic dilemma. Br Heart J 58: 6–8

    Article  PubMed  CAS  Google Scholar 

  9. Ohlsen EGJ (1985) The problem of viral heart disease: how often do we miss it? Postgrad Med J 61: 479–480

    Article  Google Scholar 

  10. Hauck AJ, Kearney DL, Edwards WD (1989) Evaluation of postmortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: Implication for role of sampling error. Mayo Clin Proc 64: 1235–1245

    PubMed  CAS  Google Scholar 

  11. Edwards WD, Holmes DR, Reeder GS (1982) Diagnosis of active lymphocytic myocarditis by endomyocardial biopsy. Quantitative criteria for light microscopy. Mayo Clin Proc 57: 419–425

    PubMed  CAS  Google Scholar 

  12. Fenoglio JJ, Ursell PC, Kellogg CF, Drusin RE, Weiss MB (1983) Diagnosis and classification of myocarditis by endomyocardial biopsy. N Engl J Med 308: 12–18

    Article  PubMed  Google Scholar 

  13. Mason JW, Billingham ME (1982) Acute inflammatory myocarditis In: Fenoglio JJ (ed) Endomyocardial biopsy: technique and applications. Boca CRC Press, Boca Raton

    Google Scholar 

  14. Kühl U, Seeberg B, Noutsias M, Schultheiß H-P (1995) Immunohistochemical analysis of the chronic inflammatory process in dilated cardiomyopathy. Br Heart J 75: 295–300

    Article  Google Scholar 

  15. Linder J, Cassling RSM, Rogler WC, Wilson JE, Markin RS, Sears TD, McManus BM (1985) Immunohistological characterization of lymphocytes in uninflamed ventricular myocardium. Arch Pathol Lab Med 109: 917–920

    PubMed  CAS  Google Scholar 

  16. Kühl U, Noutsias M, Seeberg B, Schannwell M, Welp LB, Schultheiß H-P, Strauer BE (1994) Chronic inflammation in dilated cardiomyopathy. J Cardiac Failure 1: 13–25

    Article  Google Scholar 

  17. Kühl U, Noutsias M, Seeberg B, Schannwell M, Welp LB, Schultheiß H-P, Strauer BE (1994) Chronic inflammation in the myocardium of patients with clinically suspected dilated cardiomyopathy. J Heart Failure (January): 231–245

    Google Scholar 

  18. Aretz HT (1987) Myocarditis, the Dallas Criteria. Hum Pathol 18: 619–624

    Article  PubMed  CAS  Google Scholar 

  19. Aretz HT, Billingham ME, Edwards WD (1986) Myocarditis: a histopathological definition and classification. J Cardiovasc Pathol 1: 3–14

    Google Scholar 

  20. Anonymous (1990) Dilated cardiomyopathy and enteroviruses (Editorials) Lancet 336: 971–973

    Google Scholar 

  21. Bowles NE, Ohlsen EGJ, Richardson PJ, Archard LC (1986) Detection of Cocksackie B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Lancet 1: 1120–1122

    Article  PubMed  CAS  Google Scholar 

  22. Grasso M, Arbusti E, Silini E, Diegoli M, Percivalle E, Ratti G, Bramerio M, Gavazzi A, Vigano M, Milanesi G (1992) Search for coxsackie B3 RNA in idiopathic dilated cardiomyopathy using gene amplification by polymerase chain reaction. Am J Cardiol 69: 658–664

    Article  PubMed  CAS  Google Scholar 

  23. Kandolf R, Ameis D, Kirschner P, Canu A, Hofschneider PH (1985) In situ detection of enteroviral genomes in myocardial cells by nucleic acid hybridization: An approach to the diagnosis of viral heart disease. Proc Natl Acad Sci 82: 4818–4822

    Article  PubMed  CAS  Google Scholar 

  24. Archard LC, Bowles NE, Cunningham I, Freeke CA, Olsen EG, Rose ML, Meany B, Why HJF, Richardson FJ (1991) Molecular probes for detection of persisting enterovirus infection of human heart and their prognostic value. Eur Heart J 12[Suppl D]: 56–59

    PubMed  Google Scholar 

  25. Neu N, Beisel KW, Traysman MD, Rose NR, Craig SW (1987) Autoantibodies specific for cardiac myosin isoform are found in mice susceptible to Coxsackie B3-induced myocarditis. J Immunol 138: 2488–2492

    PubMed  CAS  Google Scholar 

  26. Limas CJ, Goldenberg JF, Limas C (1989) Autoantibodies against β-adrenoceptors in human idiopathic dilated cardiomyopathy. Circ Res 64: 97–103

    PubMed  CAS  Google Scholar 

  27. Schultheiss HP, Ulrich G, Janda I, Kühl U, Morad M (1988) Antibody-mediated enhancement of calcium permeability in cardiac myocytes. J Exp Med 168: 2105–2119

    Article  PubMed  CAS  Google Scholar 

  28. Wolff P, Kühl U, Schultheiss HP (1989) Laminin distribution and autoantibodies to la-minin in dilated cardiomyopathy and myocarditis. Am Heart J 117: 1303–1309

    Article  PubMed  CAS  Google Scholar 

  29. Schulze K, Becker BF, Schauer R, Schultheiss HP (1990) Antibodies to the ADP/ATP carrier — and autoantigen in myocarditis and dilated cardiomyopathy — impair cardiac function. Circulation 81: 959–969

    Article  PubMed  CAS  Google Scholar 

  30. Schulze K, Becker BF, Schultheiß HP (1989) Antibodies to the ADP/ATP carrier, an autoantigen in myocarditis and dilated cardiomyopathy, penetrate into myocardial cells and disturb energy metabolism in vivo. Circ Res 64: 179–192

    PubMed  CAS  Google Scholar 

  31. Duijvestijn A, Hamann A (1990) Mechanisms and regulation of lymphocyte migration. Immunology Today 10: 23–28

    Article  Google Scholar 

  32. van Seventer GA, Shimizu Y, Horgan KJ, Shaw S (1990) The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T-cell receptor-mediated activation of resting T cells. J Immunol 144: 4579–4586

    PubMed  Google Scholar 

  33. Hughes CCW, Savage COS, Pober JS (1990) The endothelial cell as regulator of T-cell function. Immunol Rev 117: 85–102

    Article  PubMed  CAS  Google Scholar 

  34. Cotran RS, Pober JS (1988) Endothelial activation: its role in inflammatory and immune reactions. Endothel Cell Biol: 335–347

    Google Scholar 

  35. Pober JS (1987) Effects of tumor necrosis factor and related cytokines on vascular endothelial cells. Ciba Foundation Symposium

    Google Scholar 

  36. Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA (1986) Induction by Il-I and interferon-gamma: tissue distribution, biochemistry and function of a natural adherence molecule (ICAM-1). J Immunol 137(1): 245–254

    PubMed  CAS  Google Scholar 

  37. Springer TA (1990) Adhesion receptors of the immune system. Review article. Nature 346: 425–434

    Article  PubMed  CAS  Google Scholar 

  38. Yong K, Khwaja A (1990) Leukocyte cellular adhesion molecules. Blood Rev 4: 211–225

    Article  PubMed  CAS  Google Scholar 

  39. Neumann DA, Lane JR, Allen GS, Herskowitz A, Rose NR (1993) Viral myocarditis leading to cardiomyopathy: do cytokines contribute to pathogenesis?. Clin Immunol Immunpathol 68: 181–190

    Article  CAS  Google Scholar 

  40. Kühl U, Schultheiß HP, Strauer BE (1994) Methylprednisolone in chronic myocarditis. Postgrad Med J 70: S35–S42

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Internal Medicine/Cardiology, Benjamin Franklin Hospital, Free University of Berlin, Hindenbargdamm 32, 12200, Berlin, Germany

    U. Kühl, M. Noutsias & H.-P. Schultheiss

Authors
  1. U. Kühl
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  2. M. Noutsias
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  3. H.-P. Schultheiss
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Editor information

Editors and Affiliations

  1. Abteilung für Kardiologie/Pulmologie, Universitätsklinikum Benjamin Franklin der Freien Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Heinz-Peter Schultheiss  & Peter Schwimmbeck  & 

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© 1997 Springer-Verlag Berlin Heidelberg

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Kühl, U., Noutsias, M., Schultheiss, HP. (1997). Immunohistochemical Analysis of Inflammatory Heart Disease. In: Schultheiss, HP., Schwimmbeck, P. (eds) The Role of Immune Mechanisms in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60463-8_10

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  • DOI: https://doi.org/10.1007/978-3-642-60463-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61358-9

  • Online ISBN: 978-3-642-60463-8

  • eBook Packages: Springer Book Archive

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