Abstract
The avian nasal gland has had an important role as a model system in studies of ion secretion for almost forty years, ever since the discovery of its role as an extrarenal salt-secreting organ by Schmidt-Nielsen and colleagues (Fänge et al. 1958). Less widely appreciated is the fact that this tissue also played a critical role in the earliest studies of the intracellular signalling pathways involved in the stimulation of cell activity. Some of the original studies demonstrating for the first time that the muscarinic stimulation of secretory activity in cells was associated with an increased turnover of membrane phosphoinositides were performed on the avian nasal gland (Hokin and Hokin 1964). Unfortunately, the key connection between this turnover of phosphoinositides and increases in cytosolic Ca2+ concentrations ([Ca]j) was not appreciated until more than ten years later (Michell 1975), and the role of inositol 1,4,5-trisphosphate in providing the critical link between these two processes was not revealed for a further eight years (Streb et al. 1983).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Berridge MJ (1990) Calcium oscillators. J Biol Chem 265: 9583–9586.
Berridge MJ (1993) Inositol trisphosphate and calcium signalling. Nature 361: 315–325.
Berridge MJ (1994) Relationship between latency and period for 5- hydroxytryptamine-induced membrane responses in the Calliphora salivary gland. Biochem J 302: 545–550.
Berridge MJ (1995) Capacitative calcium entry. Biochem. J 312: 1–11.
Bezprozvanny I, Ehrlich BE (1995) The inositol 1,4,5-trisphosphate (InsP3) receptor. J Memb Biol 145: 205–216.
Bezprozvanny I, Watras J, Ehrlich BE (1991) Bell-shaped calcium-response curves of Ins (1,4,5)P3_ and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature 351: 751–754.
De Young GW, Keizer J (1992) A single-pool IP3-receptor-based model for agonist stimulated Ca2+ oscillations. Proc Natl Acad Sci USA 89: 9895–9899.
Fänge R, Schmidt-Nielsen K, Robinson M (1958) Control of secretion from the avian salt gland. Am J Physiol 195: 321–326.
Finch EA, Turner TJ, Goldin SM (1991) Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release. Science 252: 443–446.
Frizzell RA, Field M, Schultz SG (1979) Sodium-coupled chloride transport by epithelial tissues. Am J Physiol 236: F1–F8.
Gerstberger R (1988) Functional vasoactive intestinal polypeptide (VlP)-system in salt glands of the Pekin duck. Cell Tissue Res 252: 39–48.
Gerstberger R, Gray A (1993) Fine structure, innervation and functional control of avian salt glands. Int Rev Cytol 144: 129–215.
Hasse P, Fourman J (1970) The autonomic innervation of the avian salt gland. J Anat 107: 382–383.
Hildebrandt J-P, Shuttleworth TJ (1993) A Gq-type G protein couples muscarinic receptors to inositol phosphate and calcium signaling in exocrine cells from the avian salt gland. J Memb Biol 133: 183–190.
Hokin LE, Hokin MR (1964) Interconversions of phosphatidylinositol and phosphatidic acid involved in the response to acetylcholine in the salt gland. In: Dawson RMC, Rhodes DN (eds) Metabolism and Physiological Significance of Lipids. John Wiley Publishers, pp. 423–434.
Hoth M, Penner R (1992) Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 355: 353–356.
Hoth M, Penner R (1993) Calcium release-activated calcium current (ICRAC) rat mast cells. J Physiol 465: 359–386.
Iino M (1990) Biphasic Ca2+ dependence of inositol 1,4,5-trisphosphate-induced Ca release in smooth muscle cells of the guinea pig taenia caeci. J Gen Physiol 95: 1103–1122.
Larsson O, Olgart L (1989) The enhancement of carbachol-induced salivary secretion by VIP and CGRP in rat parotid gland is mimicked by forskolin. Acta Physiol Scand 137: 231–236.
Larsson O, Detsch T, Fredholm BB (1990) VIP and forskolin enhance carbachol-induced K+ efflux from rat salivary gland fragments by a Ca2+ -sensitive mechanism. Am J Physiol 259: C904–C910.
Lowy RJ, Ernst SA (1987) ß-adrenergic stimulation of ion transport in primary cultures of avian salt glands. Am J Physiol 252: C670–C676.
Lowy RJ, Dawson DC, Ernst SA (1985) Primary culture of duck salt gland II. Neurohormonal stimulation of active transport. Am J Physiol 249: C41–C47.
Lowy RJ, Schreiber, Ernst SA (1987) Vasoactive intestinal peptide stimulates ion transport in avian salt gland. Am J Physiol 253: R801–R808.
Lundberg JM, Ånggård A, Fahrenkrug J (1982) Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion. Acta Physiol Scand 114: 329–337.
Lytle C, Forbush B III (1996) Regulatory phosphorylation of the secretory Na-K- Cl cotransporter: modulation by cytoplasmic CI. Am J Physiol 270: C437–C448.
Martin SC, Shuttleworth TJ (1994a) Muscarinic-receptor activation stimulates oscillations in K+ and CI- currents which are acutely dependent on extracellular Ca2+ in avian salt gland cells. Pflügers Archiv 426: 231–238.
Martin SC, Shuttleworth TJ (1994b) Ca2+ influx drives agonist-activated [Ca2+]i oscillations in an exocrine cell. FEBS Lett 352: 32–36.
Martin SC, Shuttleworth TJ (1994c) Vasoactive intestinal peptide stimulates a cAMP-mediated CI current in avian salt gland cells. Regul Peptides 52: 205–214.
Martin SC, Shuttleworth TJ (1995) Activation by ATP of a P2U ‘nucleotide’ receptor in an exocrine cell. Brit J Pharmacol 115: 321–329.
Martin SC, Thompson JL, Shuttleworth TJ (1994) Potentiation of Ca2+-activated secretory activity by a cAMP-mediated mechanism in avian salt gland cells. Am J Physiol 267: C255–C265.
Michell RH (1975) Inositol phospholipids and cell surface receptor function. Biochim Biophys Acta 415: 81–147.
Mikoshiba K (1993) Inositol 1,4,5-trisphosphate receptor. Trends Pharm Sci 14: 86–89.
Peaker M, Linzell JL (1975) Salt glands in birds and reptiles. Cambridge Univ Press, London.
Petersen OH (1992) Stimulus-secretion coupling: cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells. J Physiol 448: 1–51.
Putney JW Jr (1986) A model for receptor-regulated calcium entry. Cell Calcium 7: 1–12.
Putney JW Jr (1990) Capacitative calcium entry revisited. Cell Calcium 11: 611–624.
Richards NW, Lowy RJ, Ernst SA, Dawson DC (1989) Two K+ channel types, muscarinic agonist-activated and inwardly rectifying, in a CI- secretory epithelium: the avian salt gland. J Gen Physiol 93: 1171–1194.
Sasaki T, Gallacher DV (1992) The ATP-induced inward current in mouse lacrimal acinar cells is potentiated by isoprenaline and GTP. J Physiol 447: 103–118.
Shuttleworth TJ (1982) Amphotericin B and the elasmobranch rectal gland - implications for the relationship between oxygen consumption and ion transport. J Exp Zool 221: 255–258.
Shuttleworth, T.J. and J.L. Thompson (1987) Secretory activity in salt glands of birds and turtles: stimulation via cyclic AMP. Am J Physiol 252: R428–R432.
Shuttleworth, T.J. and J.L. Thompson (1989) Intracellular [Ca2+] and inositol phosphates in avian nasal gland cells. Am J Physiol 257: C1020–C1029.
Shuttleworth TJ (1994) InsP3 receptor and intracellular Ca2+ release. In: Peracchia C (ed) Handbook of Membrane Channels: Molecular and Cellular Physiology. Academic Press, pp 495–509.
Shuttleworth TJ (1995) Intracellular signals controlling ionic and acid-base regulation in avian nasal gland cells. In: Heisler N (ed) Mechanisms of Systemic Regulation: Acid-base Regulation, Ion transfer and Metabolism, Advances in Comparative and Environmental Physiology, vol 22. Springer Verlag, Berlin, pp. 185–206.
Shuttleworth TJ, Thompson JL (1996a) Ca2+ entry modulates oscillation frequency by triggering Ca2+ release. Biochem J 313: 815–819.
Shuttleworth TJ, Thompson JL (1996b) Evidence for a non-capacitative Ca2+ entry during [Ca2+] oscillations. Biochem J 316: 819–824.
Streb H, Irvine RF, Berridge MJ, Schulz I (1983) Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306: 67–69.
Taylor CW, Traynor D (1995) Calcium and inositol trisphosphate receptors. J Memb Biol 145 109–118.
Torchia J, Qu Y, Francis J, Pon DJ, Sen AK (1991) Carbachol-stimulated phosphorylation of a 170-kDa endogenous protein in avian salt gland cells. Am J Physiol 261: C543–C549.
Thorn JP (1995) Ca2+ influx during agonist and Ins(2,4,5)P3-evoked Ca2+ oscillations in HeLa epithelial cells. J Physiol 482: 275–281.
Wu JV, Shuttleworth TJ, Stampe P (1996) Grouped calcium titration curves: gating components of the calcium-activated K+ channels may be heterotetramous. Biophys J 70: A192.
Zweifach A, Lewis RS (1995a) Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback. J Gen Physiol 105: 209–226.
Zweifach A, Lewis RS (1995b) Slow calcium-dependent inactivation of depletion- activated calcium current. J Biol Chem 270: 14445–14451.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Shuttleworth, T.J., Thompson, J.L., Martin, S.C. (1997). Intracellular signalling in salt-secreting cells - recent advances in the avian nasal gland model. In: Hazon, N., Eddy, F.B., Flik, G. (eds) Ionic Regulation in Animals: A Tribute to Professor W.T.W.Potts. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60415-7_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-60415-7_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64396-5
Online ISBN: 978-3-642-60415-7
eBook Packages: Springer Book Archive