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The Role of Endogenous Interferon-α in HIV Infection and Autoimmune Diseases—An Overview

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Interferons

Abstract

In the course of HIV infection, the role of interferon-α (IFN-α) seems to be rather paradoxical: “It is possible to view alpha-IFN as either a therapeutical agent or as a major contributor to the pathology associated with AIDS.” (S. Krown, 1992).

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References

  1. Krown SE, Niedzwiecki D, Bhalla RB, Flomenberg N, Bundow D, Chapman D (1991) Relationship and prognostic value of endogenous alpha-IFN, b2-microglobuline, and neopterin serum levels in patients with Kaposi’s Sarcoma and AIDS. J Acquir Immune Defic Syndr, 4: 871–880

    PubMed  CAS  Google Scholar 

  2. Mildvan D, Machado SG, Wilets I, Grossberg SE (1992) Endogenous IFN and triglyceride concentrations to assess response to zidovudine in AIDS and advanced AIDS-related complex. Lancet 339: 453–456

    Article  PubMed  CAS  Google Scholar 

  3. Hess G, Rossol S, Rossol, R, Meyer zum Buschenfelde KH (1991) TNF and IFN as prognostic markers in HIV-infection. Infection 19 [Suppl 2]: 93–97

    Article  Google Scholar 

  4. Francis ML, Meltzer MS, Gendelman HE (1992) IFN’s in the persistence, pathogenesis, and treatment of HIV-infection. AIDS Res Hum Retroviruses 8: 199–207

    Article  PubMed  CAS  Google Scholar 

  5. Voth RS, Rossol S, Klein K et al (1990) Differential gene expression of alpha-IFN and TNF-alpha in PBMCs from patients with AIDS-related complex and AIDS. J Immunol 144: 970–975

    PubMed  CAS  Google Scholar 

  6. Howell DM, Feldman M, Siegal FP, Pettera L, Fitzgerald-Bocarsly P (1993) Peripheral blood of AIDS patients contains cells capable of providing accessory function of the natural killer cell-mediated lysis of herpes simplex virus-infected targets despite low alpha-IFN production. J Acquir Immune Defic Syndr 6: 15–23

    PubMed  CAS  Google Scholar 

  7. Lallemand CP, Rizza P, Lebon P (1991) Mechanisms of the inhibition of the IFN response in HIV-infected cells. Congr Biotech AIDS 94, p 157 (abstract)

    Google Scholar 

  8. Levy DE (1993) Induction of alpha-IFN stimulated gene expression. Forum-Trends in Experimental and Clinical Medicine 3: 641–650

    Google Scholar 

  9. Gutch MJ, Reich N (1991) Repression of the interferon signal transduction pathway by adenovirus particles EiA oncogene. Proc Natl Acad Sci USA 88: 7914–7917

    Article  Google Scholar 

  10. Foster GR (1991) Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to alpha- and gamma-interferons and double-stranded RNA.Proc Natl Acad Sci USA 88: 2888–2892

    Article  PubMed  CAS  Google Scholar 

  11. Ferbas JJ, Toso JF, Logar AJ, Navratil JS, Rinaldo CR (1994) CD4(+) blood dendritic cells are potent producers of alpha-IFN in response to in vitro HIV-i infection. J Immunol 152: 4649–4662

    PubMed  CAS  Google Scholar 

  12. Feldman SB, Milone MC, Kloser P, Fitzgerald-Bocarsly P (1995) Functional deficiences in two distinct alpha-IFN producing cell populations in PBMCs from HIV-seropositive patients. J Leuk Biol 57: 214–220

    CAS  Google Scholar 

  13. Tyring SK, Cauda R, Tumbarellov M et al (1991) Synthetic peptides corresponding to sequences in HIV-envelope gp4i and gpi20 enhance in vitro production of IL-i and TNF, but depress production of alpha-IFN, gamma-IFN and IL-2. Viral Immunol 4: 33–42

    Article  PubMed  CAS  Google Scholar 

  14. Nair MPN, Kailash CC, Stadler I, Sweet A, Schwartz SA (1995) Differential effects of HI V-i envelope protein gp 120 on IFN production by mononuclear cells from adults and neonates. Clin Diagn Lab Immunol 22: 432–438

    Google Scholar 

  15. Grunfeld C, Kotler DP, Shigenaga JK et al (1991) Circulating alpha-IFN levels and hypertriglyceridemia in the acquired immunodeficiency syndrome. Am J Med 90: 154–162

    PubMed  CAS  Google Scholar 

  16. Von Sydow M, Sonnerborg A, Gaines H, Strannegard O (1991) Alpha-IFN and TNF-alpha in serum of patients in various stages of HIV-i infection. AIDS Res Hum Retroviruses 7: 375–380

    Article  Google Scholar 

  17. Rossol S, Voth R, Laubenstein HP et al (1989) IFN-production in patients infected with HIV-i. J Infect Dis 159: 815–821

    Article  PubMed  CAS  Google Scholar 

  18. Lau AS, Livesey JF (1989) Endotoxin induction of TNF is enhanced by acid-labile alpha-IFN in AIDS. J Clin Invest 84: 738–743

    Article  PubMed  CAS  Google Scholar 

  19. Poli G, Biswas P, Fauci AS (1994) IFN’s in the pathogenesis and treatment of HIV-infection. Antiviral Research 24: 221–233

    Article  PubMed  CAS  Google Scholar 

  20. Edlin BR, St. Clair MH, Pitha PM et al (1992) In-vitro resistance to zidovudine and alpha-IFN in HIV-i isolates from patients: correlations with treatment duration and response. Ann Intern Med 117: 457–460

    PubMed  CAS  Google Scholar 

  21. Capobianchi MR, Ankel H, Ameglio F, Paganelli R, Pizzoli PM, Dianzani F (1992) Recombinant glycoprotein 120 of HIV is a potent IFN inducer. AIDS Res Hum Retroviruses 8: 575–579

    Article  PubMed  CAS  Google Scholar 

  22. Francis ML, Meitzer MS (1993) Induction of alpha-IFN by HIV-i in monocyte-enriched PBM requires gp 120-CD4 interaction but not virus replication. J Immunol 151: 2208–2216

    PubMed  CAS  Google Scholar 

  23. Buimovici-Klein E, McKinley GF, Lange M et al (1992) Modulation of alpha-IFN levels by AZT treatment in HIV-seropositive patients. J Exp Pathol 6: 31–39

    PubMed  CAS  Google Scholar 

  24. Torres G (1993) Use of alpha-IFN’s in HIV-disease. In: Jäger H (ed) AIDS: Eine Krankheit wird behandelbar. Ecomed Verlagsgesellschaft, Landsberg, p 189–193

    Google Scholar 

  25. Schröder HC, Müller WEG, Pfleiderer W (1992) With oligoadenylates and intracellular immunity against retroviruses. Nachr Chem Tech Lab 40: 1352–1360

    Article  Google Scholar 

  26. Cohen B, Gothelf Y, Vaiman D, Chen L, Revel M, Chebath J (1991) IL-6 induces the 2–5 oligoadenylate synthetase gene in Mi cells through an effect on the IFN-responsive enhancer. Cytokine 3: 83–91

    Article  PubMed  CAS  Google Scholar 

  27. Von Wussow P, Jakschies D, Hochkeppel HK, Fibich C, Penner L, Deicher H (1990) The human intracellular Mx-homologous protein is specifically induced by type 1 IFN’s. Eur J Immunol 20: 2015–2019

    Article  Google Scholar 

  28. Jakschies D, Zachaval R, Müller R et al (1994) Strong transient expression of the type 1 IFN-induced MxA protein in hepatitis A but not in acute hepatitis B and C. Hepatology 19: 857–865

    PubMed  CAS  Google Scholar 

  29. Pitha PM, Popik W, Su Y (1995) Targeted expression of the transduced IFN-α gene: application for gene therapy, 1st International Symp on HIV & Cytokines, (abstract) p 53

    Google Scholar 

  30. Lallemand C, Tovey MG (1995) Differential expression of constitutive type 1 IFN in U937 cells infected or not by HIV. 1st International Symp on HIV 8c Cytokines, (abstract) p 76

    Google Scholar 

  31. Leissner P, Calenda V, Marigliano M (1995) Gene therapy for HIV-i infection: inhibition of viral replication by HIV-i inducible IFN-alpha-, beta- and gamma-genes, 1st International Symp on HIV 8c Cytokines, (abstract) 15, p 51

    Google Scholar 

  32. Yee AM, Buyon JP, Yip YK (1989) Alpha-IFN associated with SLE is not intrinsically acid-labile. J Exp Med 169: 987–993

    Article  PubMed  CAS  Google Scholar 

  33. Krieg AM, Steinberg AD (1990) Retroviruses and autoimmunity. J Autoimmun 3: 137–166

    Article  PubMed  CAS  Google Scholar 

  34. Ranki A, Kurki P, Riepponen S, Stephansson E (1992) Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies. Arthritis Rheum 35: 1483–1491

    Article  PubMed  CAS  Google Scholar 

  35. Blomberg J, Nived O, Pipkorn R, Bengtsson A, Erlinge D, Sturfelt G (1994) Increased antiretroviral antibody reactivity in sera from a defined population of patients with SLE. Correlation with autoantibodies and clinical manifestations. Arthritis Rheum 37: 57–66

    Article  PubMed  CAS  Google Scholar 

  36. Toivanen P, Toivanen A, Brines R (1994) When is autoimmune disease not an autoimmune disease? Immunol Today 15: 556–559

    Article  PubMed  CAS  Google Scholar 

  37. Clerici M, Shearer GM (1994) The Thi-Th2-hypothesis of HIV-infection: new insights. Immunol Today 15: 575–581

    Article  PubMed  CAS  Google Scholar 

  38. Ho DD, Mougdil MS, Alam M (1989) Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. New Engl J Med 321: 1621–1625

    Article  PubMed  CAS  Google Scholar 

  39. Kelso A (1995) Thi and Th2 subsets: paradigms lost? Immunol Today 16: 374–379

    Article  PubMed  CAS  Google Scholar 

  40. Inaba K, Schuler G, Steinman RM (1993) GM-CSF-α granulocyte/macrophage/dendritic cell stimulation factor. In: Van Furth R (ed) Hematopoetic growth factors and mononuclear phagocytes. Karger, Basel, pp 187–196

    Google Scholar 

  41. Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Ann Rev Immunol 9: 271–296

    Article  CAS  Google Scholar 

  42. Grabbe S, Beissert S, Schwarz T, Granstein RD (1995) Dendritic cells as initiators of tumor immune responses: a possible strategy for tumor immunity? Immunol Today 16: 117–121

    Article  PubMed  CAS  Google Scholar 

  43. Lamont A (1994) Are we closer to selective immunotherapy for autoimmune diseases? Immunol Today 15: 45–47

    Article  PubMed  CAS  Google Scholar 

  44. Hohlfeld R, Londei M, Massacesi L, Salvetti M (1995) T-cell autoimmunity in multiple sclerosis. Immunol Today 16: 259–261

    Article  PubMed  CAS  Google Scholar 

  45. Report of the Quality Standards Subcommittee of the American Academy of Neurology (1994). Neurology, 44: 1537–1540

    Google Scholar 

  46. Segel LA, Jäger E, Elias D, Cohen IR (1995) A quantitative model of autoimmune disease and T-cell vaccination: does more mean less? Immunol Today 16: 80–84

    Article  PubMed  CAS  Google Scholar 

  47. Theofilopoulos AN (1995) The basis of autoimmunity. Part 1: mechanisms of aberrant self-recognition. Immunol Today 16: 90–98

    Article  PubMed  CAS  Google Scholar 

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© 1997 Springer-Verlag Berlin Heidelberg

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Tossing, G. (1997). The Role of Endogenous Interferon-α in HIV Infection and Autoimmune Diseases—An Overview. In: Aul, C., Schneider, W. (eds) Interferons. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60411-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-60411-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61051-9

  • Online ISBN: 978-3-642-60411-9

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