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Preventing Postischemic Injury During Reperfusion

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Stroke

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 27))

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Abstract

With the advent of thrombolysis and the ability to reperfuse during focal ischemia, the question arises of what type of neuroprotective drugs can be used in combination with thromblytic therapy to prevent focal injury from occurring. From an experimental point of view, there are three groups: anti-excitatory drugs, antioxidants, and inhibitors of leukocyte inflammatory response.

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References

  1. Margaill I, Parmentier S, Callebert J, et al (1996) Short therapeutic window for MK-801 in transient focal cerebral ischemia in mornotensive rats. J Cereb Blood Flow Metab 16:107–113

    Article  PubMed  CAS  Google Scholar 

  2. DeGraba TJ, Ostrow PT, Grotta JC (1993) Threshold of calcium disturbances after focal cere¬bral ischemia in rats. Stroke 24:1212–1217

    Article  PubMed  CAS  Google Scholar 

  3. Gill R, Andine P, Hillered L, et al (1992) The effect of MK-801 on cortical spreading depres¬sion in the penumbral zone following focal ischemia in the rat. J Cereb Blood Flow Metab 12: 371–379

    Article  PubMed  CAS  Google Scholar 

  4. Nishikawa T, Kirsch JR, Koehler RC, et al (1994) Competitive N-methyl-D-aspartate receptor blockage reduces brain injury following transient focal ischemia in cats. Stroke 25:2258–2264

    Article  PubMed  CAS  Google Scholar 

  5. Miyabe M, Kirsch JR, Nishikawa T, et al (1997) Comparative analysis of brain protection by N-methyl-D-aspartate receptor antagonists after transient focal ischemia in cats. Crit Care Med 25:1037–1043

    Article  PubMed  CAS  Google Scholar 

  6. Muir KW, Lees KR (1995) Clinical experience with excitatory amino acid antagonist drugs. Stroke 26:503–513

    Article  PubMed  CAS  Google Scholar 

  7. Hanner M, Moebius FF, Flandorfer A, et al (1996) Purification, molecular cloning, and ex-pression of the mammalian sigma-binding site. Proc Natl Aca Sci USA 93:8072–8077

    Article  CAS  Google Scholar 

  8. Walker JM, Bowen WD, Walker FO, et al (1990) Sigma receptors:biology and function. Phar-macol Rev 42:355–402

    CAS  Google Scholar 

  9. Lockhart BP, Soulard P, Benicourt C, et al (1995) Distinct neuroprotective profiles for sigma ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies. Brain Res 675:110–120

    Article  PubMed  CAS  Google Scholar 

  10. Lysko PG, Feuerstein G (1990) Excitatory amino acid neurotoxicity at the N-methyl-D- aspartate receptor in cultured neurons:protection by SKF 10,047. Neurosci Lett 120:217–220

    Article  PubMed  CAS  Google Scholar 

  11. Contreras PC, Gray NM, Ragan DM, et al (1992) BMY-14802 protects against ischemia- induced neuronal damage in the gerbil. Life Sci 51:1145–1149

    Article  PubMed  CAS  Google Scholar 

  12. Lysko PG, Yue T-L, Gu J-L, et al (1992) Neuroprotective mechanism of (+) SKF 10,047 in vitro and in gerbil global brain ischemia. Stroke 23:1319–1324

    Article  PubMed  CAS  Google Scholar 

  13. O’Neill M, Caldwell M, Earley B, et al (1995) The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischemia. Eur J Pharmacol 283:217–225

    Article  PubMed  Google Scholar 

  14. Takahashi H, Kirsch JR, Hashimoto K, et al (1995) PPBP [4-phenyl-l-(4-phenylbutyl) piperi- dine], a potent sigma-receptor ligand, decreases brain injury following transient focal ischemia in cats. Stroke 26:1676–1682

    Article  PubMed  CAS  Google Scholar 

  15. Takahashi H, Kirsch JR, Hashimoto K, et al (1996) PPBP [4-phenyl-l-(4-phenylbutyl) piperi- dine] decreases brain injury after transient focal ischemia in rats. Stroke 27:2120–2123

    Article  PubMed  CAS  Google Scholar 

  16. Takahashi H, Traystman RJ, Hashimoto K, et al (1997) Postischemic brain injury is affected stereospecifically by pentazocine in rats. Anesth Analg 85:353–357

    PubMed  CAS  Google Scholar 

  17. Lesage AS, De Loore KL, Peeters L, et al (1995) Neuroprotective sigma ligands interefere with the glutamate-activated NOS pathway in hippocampal cell culture. Synapse 20:156–164

    Article  PubMed  CAS  Google Scholar 

  18. Bhardwaj A, Northington FJ, Hanley DF, et al (1996) Striatal nitric oxide (NO) production is enhanced in focal cerebral ischemia:An in vivo microdialysis study. Presented at a meeting on Emergency Management and Critical Care of Stroke, Heidelberg, September 1996

    Google Scholar 

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© 1998 Springer-Verlag Berlin Heidelberg

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Koehler, R.C., Kirsch, J.R., Bhardwaj, A., Takahashi, H., Traystman, R.J. (1998). Preventing Postischemic Injury During Reperfusion. In: Steiner, T., Hacke, W., Hanley, D.F. (eds) Stroke. Update in Intensive Care and Emergency Medicine, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60264-1_9

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  • DOI: https://doi.org/10.1007/978-3-642-60264-1_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64326-2

  • Online ISBN: 978-3-642-60264-1

  • eBook Packages: Springer Book Archive

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