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Morphologische und funktionelle Bildgebung

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Alzheimer Demenz

Zusammenfassung

Die Alzheimer Demenz (AD) ist eine degenerative Hirnerkrankung, die in der Regel einen chronisch-progredienten Verlauf nimmt. In den Anfangsstadien bleiben zerebrale Veränderungen auf den entorhinalen Kortex, die Substrukturen des medialen Temporallappens sowie den parietalen Kortex beschränkt, um in späteren Stadien auch auf den temporalen und frontalen Kortex überzugreifen. Lediglich die primären sensorischen und sensomotorischen Kortizes bleiben in der Regel ausgespart (Spar u. La Rue, 1997).

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Literatur

  • Alexander GE, Furey ML, Grady CL, Pietrini P, Brady DR, Mentis MJ, Schapiro MB (1997) Association of promorbid intellectual function with cerebral metabolism in Alzheimer’s disease: implications for the cognitive reserve hypothesis. Am J Psychiatry 154: 165–172

    PubMed  CAS  Google Scholar 

  • Andreasen NC, O’Leary DS, Arndt S et al. (1995) Short-term and long-term verbal memory: A positron emission tomography study. Proc Natl Acad Sei 92: 5111–5115

    Article  CAS  Google Scholar 

  • Barclay LL, Brady PA (1992) Cerebellar atrophy as a CT marker for mixed dementia. Biol Psychiatry 31: 520–524

    Article  PubMed  CAS  Google Scholar 

  • Benson DF (1982) The use of positron emission scanning techniques in the diagnosis of Alzheimer’s disease. In: Corkin S et al. (eds) Alzheimer’s disease. A report of progress in research. Raven Press, New York

    Google Scholar 

  • Buch K, Riemenschneider M, Bartenstein P et al. (1998) Tau-Protein. Ein potentieller biologischer Indikator zur Früherkennung der Alzheimer-Krankheit. Nervenarzt 69: 379–385

    Article  PubMed  CAS  Google Scholar 

  • Buchsbaum MS, Kesslak P, Lynch G et al. (1991) Temporal and hippocampal metabolic rate during an olfactory memory task assessed by positron emission tomography in patients with dementia of the Alzheimer type and controls. Arch Gen Psychiatry 48: 840–847

    PubMed  CAS  Google Scholar 

  • Cardebat D, Demonet JF, Puel M, Agniel A, Viallard G, Celsis P (1998) Brain correlates of memory processes in patients with dementia of Alzheimer’s type: A SPECT activation study. J Cerebral Blood Flow Metabol 18: 457–462

    Article  CAS  Google Scholar 

  • Cervos-Navarro J, Diemer NH (1991) Selective vulnerability in brain hypoxia. Crit Rev Neurobiol 6: 149–182

    PubMed  CAS  Google Scholar 

  • Convit A, de Leon MJ, Tarshish C, De Santi S, Kluger A, Rusinek H, George AE (1995) Hippocampal volume losses in minimally impaired elderly. Lancet 345: 266

    Article  PubMed  CAS  Google Scholar 

  • Coffey CE, Wilkinson WE, Weiner RD, Parashos IA, Djang WT, Webb MC, Figiel GS, Spritzer CE (1993) Quantitative cerebral anatomy in depression. A controlled magnetic resonsance study. Arch Gen Psychiatry 50: 7–16

    PubMed  CAS  Google Scholar 

  • Corder EH, Jelic V, Basun H, Lannfelt L, Valind S, Winblad B, Nordberg A (1997) No differences in cerebral glucose metabolism in patients with Alzheimer disease and differing apolipoprotein E genotypes. Arch Neurol 54: 273–277

    PubMed  CAS  Google Scholar 

  • Cudnod CA, Denys A, Michot JL, Jehenson P, Forette F, Kaplan D, Syrota A, Boller F (1993) Amydgala atrophy in Alzheimer’s disease. An in vivo magnetic resonance imaging study. Arch Neurol 50: 941–945

    Google Scholar 

  • DeCarli C, Murphy DGM, Mclntosh AR, Teichberg D, Schapiro MB, Horwitz B (1995) Discriminant analysis of MRI measures as a method to determine the presense of dementia of the Alzheimer type. Psychiatry Res 57: 119–130

    Article  Google Scholar 

  • DeLacoste MC, Kirkpatrick JB, Ross ED (1985) Topography of the human corpus callosum. J Neuropathol Exp Neurol 44: 578–591

    Article  PubMed  Google Scholar 

  • Delis DC, Freeland J, Kramer JH, Kaplan E (1987) Integrating clinical assessment with cognitive neuroscience: construct Validation of the California Verbal Learning Test. J Consult Clin Psychol 56: 123–130

    Google Scholar 

  • Desrosiers G (1992) Primary or depressive dementia: clinical features. Int J Geriatr Psychiatry 7: 629–638

    Article  Google Scholar 

  • Erkinjuntti T (1987) The matter with the white matter. In: Bergener M et al. (eds) Health, aging and healing. Springer, New York, pp 83–97

    Google Scholar 

  • Fama R, Sullivan EN, Shear PK, Marsh L, Yesavage JA, Tinklenberg JR, Lim KO, Pfefferbaum A (1997) Selective cortical and hippocampal volume correlates of Mattis dementia rating scale in Alzheimer disease. Arch Neurol 54: 719–728

    PubMed  CAS  Google Scholar 

  • Farkas T, Ferris SH, Wolf AP et al. (1982) F-2-deoxy-2-fluoro-D-glucose as a tracer in the positron emission tomographic study of senile dementia. Am J Psychiatry 139: 352–353

    PubMed  CAS  Google Scholar 

  • Folstein MF, Folstein SE, Mchugh PR (1975) “Mini-mental-state”: a practical method for grading the cognitive State of patients for the clinician. J Psychiatr Res 12: 189–198

    Article  PubMed  CAS  Google Scholar 

  • Foundas AL, Eure KF, Seltzer B (1996) Conventional MRI Volumetrie measures of parietal and insular cortex in Alzheimer’s disease. Prog Neuro-Psychopharmacol & Biol Psychiat 20: 1131–1144

    Article  CAS  Google Scholar 

  • Förstl H, Sattel H, Sarochan N et al. (1996) Alzheimer Demenz und normales Altern. Klinische, neuroradiologische, neurophysiologische und molekularbiologische Verlaufsdaten. Nervenarzt 67: 730–738

    Article  PubMed  Google Scholar 

  • Foster NL, Chase TN, Fedio P, Patronas NJ, Brooks RA, Di-Chiro G (1983) Alzheimer’s disease: focal cortical changes shown by positron emission tomography. Neurology 33: 961–965

    PubMed  CAS  Google Scholar 

  • Friedlinger M, Schad LR, Blüml S, Tritsch B, Lorenz WJ(1995) Rapid automatic brain volumetry on the basis of multispectral 3D MR imaging data on personal Computers. Comput Med Imag Graph 19: 185–205

    Article  CAS  Google Scholar 

  • Frisoni BF, Trabucchi M, Beltramello A (1996) Hippocampal atrophy measurement in Alzheimer’s disease. Int J Geriatr Psychiatry 11: 81–83

    Article  Google Scholar 

  • Gemmell HG, Sharp PF, Besson JAO, Crawford JR, Ebmeier KP, Davidson J, Smith FW (1987) Differential diagnosis in dementia using the cerebral blood flow agent ŇmTcHM-PAO: A SPECT study. J Comput Assist Tomography 11: 398–402

    Article  CAS  Google Scholar 

  • Grady CL, Haxby JV, Schlageter NL, Berg G, Rapoport SI (1986) Stability of metabolic and neuropsychological asymmetries in dementia of the Alzheimer type. Neurology 36: 1390–1392

    PubMed  CAS  Google Scholar 

  • Grasby PM, Frith CD, Friston KJ, Frackowiak RSJ, Dolan RJ (1993) Activation of the human hippocampal formation during auditory-verbal long-term memory function. Neurosci Lett 163: 185–188

    Article  PubMed  CAS  Google Scholar 

  • Hagberg B, Ingvar DH (1976) Cognitive reduetion in presenile dementia related to regional abnormalities of the cerebral blood flow. Brit J Psychiatr. 128: 209–222

    Article  CAS  Google Scholar 

  • Haxby JV, Grady CL, Koss E, Horwitz B, Schapiro M, Friedland RP, Rapoport SI (1988) Heterogeneous anterior-posterior metabolic patterns in dementia of the Alzheimer type. Neurology 38: 1853–1863

    PubMed  CAS  Google Scholar 

  • Heiss WD, Szelies B, Adams R, Kessler J, Pawlik G, Herholz K (1990) PET criteria for the diagnosis of Alzheimer’s disease and other dementias. In: Maurer K et al. (eds) Alzheimer’s disease. Epidemiology, neuropathology, neurochemistry, and clinics. Springer, Wien New York, pp 473–487

    Google Scholar 

  • Herholz K (1995) FDG PET and differential diagnosis of dementia. Alzheimer Dis Assoc Disord 9: 6–16

    Article  PubMed  CAS  Google Scholar 

  • Ingvar DH, Gustafson L (1970) Regional cerebral blood flow in organic dementia with early onset. Acta Neurol Scand 46: 42–73

    Article  PubMed  Google Scholar 

  • Jack CR, Twomey CK, Zinsmeister AR, Sjarbrough FW, Petersen RC, Cascino GD (1989) Anterior temporal lobes and hippocampal formations: normative Volumetrie measurements from MR images in young adults. Radiology 172: 549–554

    PubMed  Google Scholar 

  • Jack CR, Petersen RC, O’Brien PC, Tangalos EG (1992) MR-based hippocampal volumetry in the diagnosis of Alzheimer’s disease. Neurology 42: 183–188

    PubMed  Google Scholar 

  • Jack CR, Petersen RC, Xu Y, O’Brien PC, Smith GE, Ivnik RJ, Tangalos EG, Kokmen E (1998a) Rate of medial temporal lobe atrophy in typical aging and Alzheimer’s disease. Neurology 51: 993–999

    PubMed  Google Scholar 

  • Jack, CR, Petersen RC, Xu YC et al. (1998b) Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer’s disease. Am Neurol 43: 303–310

    Article  Google Scholar 

  • Jauss M, Schröder J, Herholz K, Pantel J et al. (1999) Frontal type dementia: clinical neuroimaging, and molecular biological findings in 6 patients (in Vorbereitung)

    Google Scholar 

  • Jobst KA, Smith AD, Barker CS et al. (1992) Association of atrophy of the medial temporal lobe with reduced blood flow in the posterior parietotemporal cortex in patients with a clinical und pathological diagnosis of Alzheimer’s disease. J Neurol Neurosurg Psychiatry 55: 190–194

    Article  PubMed  CAS  Google Scholar 

  • Jobst KA, Smith AD, Szatmari M, Esiri MM, Jaskowski A, Hindley N, McDonald B, Molyneux AJ (1994) Rapidly progressing atrophy of medial temporal lobe in Alzheimer’s disease. Lancet 343: 829–830

    Article  PubMed  CAS  Google Scholar 

  • Juottonen K, Lehtovirta S, Helisalmi S, Riekkinen PJ sr, Soininen H (1998) Major decrease in the volume of the entorhinal cortex in patients with Alzheimer’s disease carrying the apolipoprotein E 84 allele. J Neurol Neurosurg Psychiatry 65: 322–327

    Article  PubMed  CAS  Google Scholar 

  • Kessler J, Herholz K, Grond M, Heiss WD (1991) Impaired metabolic activation in Alzheimer’s disease: A PET study during continuous Visual recognition. Neuropsychol 29: 229–243

    Article  CAS  Google Scholar 

  • Laakso MP, Partanen K, Riekkinen P et al. (1996) Hippocampal volumes in Alzheimer’s disease, Parkinson’s disease with and without dementia, and in vascular dementia. Neurology 46: 678–681

    PubMed  CAS  Google Scholar 

  • Lehtovirta K, Laakso MP, Soininen H et al. (1995) Volumes of hippocampus, amygdala, and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes. Neuroscience 67: 65–72

    Article  PubMed  CAS  Google Scholar 

  • Mathalon DH, Sullivan FV, Rawles JM, Pfefferbaum A (1993) Correction for head size in brain-imaging measurements. Psychiatry Res Neuroimaging 50: 121–139

    Article  CAS  Google Scholar 

  • Mann UM, Mohr E, Gearing M, Chase TN (1992) Heterogeneity in Alzheimer’s disease: progression rate segregated by distinet neuropsychological and cerebral metabolic profiles. J Neurol Neurosurg Psychiatry 55: 956–959

    Article  PubMed  CAS  Google Scholar 

  • Markowitsch HJ (1997) Neuropsychologie des Gedächtnisses. In: Förstl H (Hrsg) Lehrbuch der Gerolitopsychiatrie. Enke, Stuttgart

    Google Scholar 

  • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM et al. (1994) Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force an Alzheimer’s disease. Neurology 34: 939–965

    Google Scholar 

  • Messa C, Perani D, Lucignani G et al. (1994) High-resolution technetium-99m-HMPAO SPECT in patients with probable Alzheimer’s disease: comparison with fluorine-18-FDG PET. J Nucl Med 35: 210–216

    PubMed  CAS  Google Scholar 

  • Mielke R, Herholz K, Grond M, Kessler J, Heiss WD (1994a) Clinical deterioration in probable Alzheimer’s disease correlates with progressive metabolic impairment of association areas. Dementia 5: 36–41

    PubMed  CAS  Google Scholar 

  • Mielke R, Pietrzyk U, Jacobs A, Fink GR, Ichiyama A, Kessler J, Herholz K, Heiss WD (1994b) HMPOA SPECT und FDG PET in Alzheimer’s disease and vascular dementia: comparison of perfusion and metabolic pattern. Eur J Nucl Med 21: 1052–1060

    Article  PubMed  CAS  Google Scholar 

  • Miller JD, De Leon MJ, Ferris SH, Kluger A, George AE, Reisberg B, Sachs HJ, Wolf AP(1987) Abnormal temporal lobe response in Alzheimer’s disease during cognitive processing as measured by C-2-deoxy-D-glucose and PET. J Cereb Blood Flow Metabol 7: 248–251

    Article  CAS  Google Scholar 

  • Murphy DGM, De Carli CD, Daly E et al. (1993) Volumetrie magnetic resonance imaging in men with dementia of the Alzheimer type: correlations with disease severity. Biol Psychiatry 34: 612–621

    Article  PubMed  CAS  Google Scholar 

  • Nybäck H, Nyman H, Blomqvist G, Sjøgren I, Stone-Elander S (1991) Brain metabolism in Alzheimer’s dementia: studies of C-deoxyglucose accumulation, CSF monoamine metabolites and neuropsychological test Performance in patients and healthy subjects. J Neurol Neurosurg Psychiatry 54: 672–678

    Article  PubMed  Google Scholar 

  • O’Brien JT, Desmond P, Arnes D, Schweitzer I, Tuckwell V, Tress B (1994) The differentiation of depression from dementia by temporal lobe magnetic resonance imaging. Psychol Med 24: 633–640

    Article  PubMed  Google Scholar 

  • Olsson Y, Brun A, Englund E (1996) Fundamental pathological lesions in vascular dementia. Acta Neurol Scand 168 (suppl): 31–38

    Article  CAS  Google Scholar 

  • Pantel J, Schröder J, Schmitt R et al. (1996) Quantitative Magnetresonanztomographie und Schweregrad der Defizite bei der Demenz vom Alzheimer-Typ. Nervenarzt 67: 46–52

    PubMed  CAS  Google Scholar 

  • Pantel J, Schröder J, Schad LR et al. (1997a) Quantitative magnetic resonance imaging and neuropsychologieal funetions in dementia of the Alzheimer type. Psychol Med 27: 221–229

    Article  PubMed  CAS  Google Scholar 

  • Pantel J, Schröder J, Essig M et al. (1997b) Quantitative magnetic resonance imaging in geriatric depression and primary degenerative dementia. J Affective Dis 42: 69–83

    Article  CAS  Google Scholar 

  • Pantel J, Schröder J, Essig M, Schneider G et al. (1998) In vivo quantifkation of brain volumes in subcortical vascular dementia and Alzheimer’s disease - An MRT based study. Dementia 9: 309–316

    CAS  Google Scholar 

  • Pantel J, Schröder J, Essig M, Minakaran R, Schad LR, Jauß M, Knopp, MV (1999) Corpus callosum in Alzheimer’s disease and vascular dementia - a quantitative magnetic resonance tomographic study. J of Cerebral Trans (Im Druck)

    Google Scholar 

  • Pantel J, Eysenbach K, Essig M, Knopp MV, Schröder J (zur Veröffentlichung eingereicht) Progression of hippocampal atrophy and clinical deterioration in Alzheimer’s disease: a MRI-Volumetrie follow-up study

    Google Scholar 

  • Pantoni L, Garcia JH, Brown GG (1996) Vascular pathology in three cases of progressive cognitive deterioration. J Neurol Sei 135: 131–139

    Article  CAS  Google Scholar 

  • Pearlson GD, Harris GJ, Powers RE, Barta PE, Camargo EE, Chase GA, Noga JT, Tune LE (1992) Quantitative changes in mesial temporal volume, regional cerebral blood flow, and Cognition in Alzheimer’s disease. Arch Gen Psychiatry 49: 402–408

    PubMed  CAS  Google Scholar 

  • Reisberg G, Ferris SH, de Leon MJ, Crook T (1982) The global deterioration scale (GDS): an instrument of the assessment of primary degenerative dementia (PDD). Am J Psychiatry 139: 1136–1139

    PubMed  CAS  Google Scholar 

  • Reisberg B, Ferris SH (1988) Brief Cognitive Rating Scale (BCRS). Psychopharmacol Bull 24: 629–636

    PubMed  CAS  Google Scholar 

  • Risberg J, Gustafson L, Brun A (1990) High resolution regional cerebral blood flow measurernents in Alzheimer’s disease and other dementia disorders. In: Maurer K et al. (eds) Alzheimer’s disease. Epidemiology, neuropathology, neurochemistry, and clinics. Springer, Wien New York, pp 509–516

    Google Scholar 

  • Schlegel S, Kretzschmar K (1987) Computed tomography in affective disorders, Part 11. Biol Psychiatry 22: 15–23

    Article  PubMed  CAS  Google Scholar 

  • Schröder J, Haan J, Dickmann E, Niedermeier T (1990) Zur Validität des cranialen Computertomogrammes in der Differentialdiagnose der Multi-Infarkt und der Demenz vom Alzheimer Typ. Z Geriatrie 3: 137–141

    Google Scholar 

  • Schröder J, Buchsbaum MS, Siegel BV, Geider FJ, Haier RJ, Lohr J, Wo J, Potkin SG (1994) Patterns of cortical activity in schizophrenia. Psychol Med 24: 947–955

    Article  Google Scholar 

  • Schröder J, Pantel J, Ida N et al. (1997) Cerebral changes and cerebrospinal fluidamyloid in Alzheimer’s disease: a study with quantitative magnetic resonance imaging. Mol Psychiatry 2: 505–507

    Article  PubMed  Google Scholar 

  • Schröder J (1998) Subsyndrome der chronischen Schizophrenie. Untersuchungen mit bildgebenden Verfahren zur Heterogenität schizophrener Psychosen. Springer, Berlin Heidelberg New York Tokio

    Google Scholar 

  • Schröder J, Buchsbaum MS, Shihabuddin L et al. (zur Veröffentlichung eingereicht) Patterns of cortical activity and mnestic Performance in Alzheimer’s disease

    Google Scholar 

  • Smith GS, DeLeon MJ, George AE et al. (1992) Topography of Crosssectional and longitudinal glucose metabolic deficits in Alzheimer’s disease. Pathophysiologie implications. Arch Neurol 49: 1142–1150

    PubMed  CAS  Google Scholar 

  • Small GW, Mazziotta JC, Collins MT et al. (1995) Apolipoprotein E type 4 Allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer Disease. JAMA 273: 942–947

    Article  PubMed  CAS  Google Scholar 

  • Spar JE, La Rue A (1997) Geriatric psychiatry. APA-Press

    Google Scholar 

  • Washington D.C. Squire LR, Ojemann JG, Miezin FM, Petersen SE, Videen TO, Raichle ME (1992) Activation of the hippocampus in normal humans: A functional anatomical study of memory. Proc Natl Acad Sei 89:1837–1841

    Article  Google Scholar 

  • Stern Y, Alexander GE, Prohovnik I, Mayeux R (1992) Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer’s disease. Arm Neurol 32: 371–375

    Article  CAS  Google Scholar 

  • Stern Y, Alexander GE, Prohovnik I, Stricks L, Links B, Lennon Mc, Mayeux R (1995) Relationship between lifetime occupation and parietal flow: implications for a reserve against Alzheimer’s disease pathology. Neurology 45: 55–60

    PubMed  CAS  Google Scholar 

  • Tanaka S, Kawainata J, Shimohama S, Akaki H, Akiguchi I, Kimura J, Ueda K (1998) Inferior temporal lobe atrophy and APOE genotypes in Alzheimer’s disease. X-ray computed tomography, magnetic resonance imaging and Xe-133 SPECT studies. Dementia 9: 90–98.

    CAS  Google Scholar 

  • Tulving E, Kapur S, Craik FIM, Moscovitch M, Houle S (1994) Hemispheric encoding retrieval asymmetry in episodic memory: Positron emission tomography findings. Proc Natl Acad Sei 91: 2016–2020

    Article  CAS  Google Scholar 

  • Wurthmann C, Bogerts B, Falkai P (1995) Brain morphology assessed by computed tomography in patients with geriatric depression, patients with degenerative dementia and normal control subjects. Psychiatry Res 61: 103–111

    Article  PubMed  CAS  Google Scholar 

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Schröder, J., Pantel, J. (1999). Morphologische und funktionelle Bildgebung. In: Förstl, H., Bickel, H., Kurz, A. (eds) Alzheimer Demenz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60228-3_8

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  • DOI: https://doi.org/10.1007/978-3-642-60228-3_8

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