Skip to main content

Zusammenfassung

Beim Einsatz von Prostaglandinen (PG) in der Geburtshilfe steht vor allem die Geburtseinleitung im Zentrum des klinischen Interesses, zumal in Deutschland 10–15% aller Geburten mit PG eingeleitet werden, an Perinatalzentren sogar bis zu 25%. Klinische Hauptprobleme jeder Geburtseinleitung sind vor allem die klare Definition der Indikation, die adäquate Wahl der Substanzen und des Applikationsmodus, die Vermeidung frustraner Einleitungen sowie uteriner Überstimulierungen mit Herztondezelerationen, Situationen, die dann häufig zur abdominalen Schnittentbindung führen, welche man eigentlich durch die Geburtseinleitung vermeiden will. Vorrangiges Ziel jeder Geburtseinleitung sollte es sein, für Mutter und Kind ein besseres perinatales Ergebnis zu erreichen als bei einer abwartenden Haltung. Vor diesem Hintergrund müssen die Ergebnisse kontrollierter randomisierter Studien bewertet werden. Die dargestellten Ergebnisse zur Geburtseinleitung mit PGE2 entstammen einer Metaanalyse von Keirse [4], der Analyse der in der Oxford Database of Perinatal Trials zusammengefaßten Studien sowie einer MEDLINE-Recherche nach randomisierten kontrollierten Studien zur Anwendung von PG zur Geburtseinleitung.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Literatur

  1. Graves GR, Baskett TF, Gray JH, Luther ER (1985) The effect of vaginal administration of various doses of Prostaglandin E2 gel on cervical ripening and induction of labor. Am J Obstet Gynecol 151: 178 – 181

    PubMed  CAS  Google Scholar 

  2. Hannah ME, Hannah WJ, Hellmann J, Hewson S, Milner R, Willan A (1992) Induction of labor as compared with serial antenatal monitoring in post–term pregnancy. N Engl J Med 326: 1587 – 1592

    Article  PubMed  CAS  Google Scholar 

  3. Hannah ME, Ohlssen A, Farine D, Hewson SA, Hodnett ED, Myhr TL, Wang EEL, Weston JA, Willan AR (1996) Induction of labor compared with expectative management; for prelabor rupture of the membranes at term. N Engl J Med 334: 1005 – 1010

    Article  PubMed  CAS  Google Scholar 

  4. Keirse MJNC: Prostaglandins in preinduction cervical ripening (1993) Meta—analysis of worldwide clinical experience. J Reprod Med 38 (suppl.): 89–98

    Google Scholar 

  5. Legarth J, Lyndrup J, Dahl C, Philipsen T, Eriksen PS (1987) Prostaglandin E2 vaginal sup– pository for induction of labour: an efficient, safe and populär method. Eur J Obstet Gynecol Reprod Biol 26: 233 – 238

    Article  PubMed  CAS  Google Scholar 

  6. Noah ML, DeCoster JM, Fräser TJ, Orr JD (1987) Preinduction cervical softening with endocervical Prostaglandin E2 gel. A multi–center trial. Acta Obstet Gynecol Scand 66: 3 – 7

    Article  PubMed  CAS  Google Scholar 

  7. Rayburn W, Gosen R, Ramadei C, Woods R, Scott J Jr (1988) Outpatient cervical ripening with Prostaglandin E2 gel in uncomplicated postdate pregnancies. Am J Obstet Gynecol 158: 1417 – 1423

    PubMed  CAS  Google Scholar 

  8. Wiqvist I, Norstrom A, Wiqvist N (1986) Induction of labor by intra–cervical Prostaglandin E2 in viscous gel. Mechanism of action and clinical treatment routines. Acta Obstet Gynecol Scand 65: 485 – 492

    Article  PubMed  CAS  Google Scholar 

  9. Nelson KB and Ellenberg JH (1986) Antecedents of cerebral palsy. Multivariate analysis of risk. N Engl J Med 315: 768 – 72

    Article  Google Scholar 

  10. Naeye RL and Peters EC (1987) Antenatal hypoxia and low IQ–values. Am J Dis Child 141: 50 – 4

    PubMed  CAS  Google Scholar 

  11. Todd AL, Trudinger BJ, Cole MJ and Cooney GH (1991) Adverse fetal welfare and out– come at two years. Journal of Maternal–Fetal Investigation 1: 101

    Google Scholar 

  12. Soothill PW, Ajayi RA, Campbell E et al. (1992) Relationship between fetal acidemia at cordocentesis and subsequent neurodevelopment. Ultrasound in Obstetrics and Gynecology 2: 80 – 3

    Article  PubMed  CAS  Google Scholar 

  13. Gaudier FL, Goldenberg RL, Nelson KG et al. (1994) Acid base status and subsequent neurosensory impairment in surviving 500–1000 g infants. Am J Obstet Gynecol 170: 48 – 53

    PubMed  CAS  Google Scholar 

  14. Karsdorp VHM, van Vugt JMG, van Geijn HP et al. (1994) Clinical significance of absent or reversed end diastolic velocity waveforms in umbilical artery. Lancet 344: 1664 – 8

    Article  PubMed  CAS  Google Scholar 

  15. Visser GHA and Huisjes JH (1977) Diagnostic value of the unstressed antepartum cardio– tocogram. Br J Obstet Gynaecol 84: 321

    Article  PubMed  CAS  Google Scholar 

  16. Dawes GS, Moulden M and Redman CWG (1992) Short term fetal heart rate Variation, decelerations, and umbilical flow velocity waveforms before labor. Obstet Gynecol 80: 673 – 8

    PubMed  CAS  Google Scholar 

  17. Griffiths R (1970) The Abilities of Young Children. A Comprehensive System of Mental Measurement for the First Eight Years of Life. The Test Agency. High Wycombe, Bucks

    Google Scholar 

  18. Lilford RJ and Braunholz D (1996) The Statistical basis of public policy: a paradigm shift is overdue. BMJ 313: 603 – 7

    PubMed  CAS  Google Scholar 

  19. Bonilla—Musoles FM, Raga F, Ballester M–J, Serra V (1994) Early detection of embryonic malformations by transvaginal and color doppler sonography. J Ultrasound Med 13: 347 – 355

    PubMed  CAS  Google Scholar 

  20. Chang AC, Huhta JC, Yoon GY, Wood DC, Tulzer G, Cohen A, Mennuti M, Norwood WI (1991) Diagnosis, transport and outcome in fetuses with left ventricular outflow tract obstrac– tion. J Thorac Cardiovasc Surg 102: 841 – 48

    PubMed  CAS  Google Scholar 

  21. Chitty LS (1995) Ultrasound Screening for fetal abnormalities. Prenatal Diagnosis 12: 1241 – 57

    Article  Google Scholar 

  22. D’Ottavio G, Meir YJ, Rustico MA, Conoscenti G, Maieron A, Fischer–Tamaro L, Mand– ruzzato G (1995) Pilot Screening for fetal malformations: possibilities and limits of transvagi¬nal sonography. J Ultrasound Med 14: 575 – 580

    Google Scholar 

  23. Ewigman BG, Crane JP, Frigoletto FD, LeFevre ML, Bain RP, McNellis D (1993) The RADIUS study group: a randomized trial of prenatal ultrasound Screening in a low risk population: impact on perinatal outcome. N Engl J Med 329: 821 – 827

    Article  PubMed  CAS  Google Scholar 

  24. Holzgreve W (1990) Sonographie Screening for anatomic defects. Seminars in Perinatology 14: 504 – 513

    PubMed  CAS  Google Scholar 

  25. Levi S, Schaaps JP, De Havay P, Coulon R, Defoort P (1995) End–result of routine ultrasound Screening for congenital anomalies: the Belgium multicenter study 1984–1992. Ultrasound Obstet Gynecol 5: 366 – 71

    Article  PubMed  CAS  Google Scholar 

  26. Nicolaides K, Brizot M, Patel F, Snijders R (1994) Comparison of chorionic villous sampling and amniocentesis for fetal karyotyping at 10–13 weeks’ gestation. Lancet 344: 435

    Article  PubMed  CAS  Google Scholar 

  27. Romero R, Ghidini A, Costigan K, Touloukian R, Hobbins JC (1989) Prenatal diagnosis of duodenal atresia: Does it make any difference? Obstet Gynecol 71: 739 – 41

    Google Scholar 

  28. Saari–Kemppainen A, Karjalainen O, Ylostalo P, Heinonen OP (1990) Ultrasound Screening and perinatal mortality: controlled trial of systematic one–stage Screening in pregnancy. The Helsinki ultrasound trial. Lancet 336: 387 – 91

    Article  Google Scholar 

  29. Tegander E, Eiknes SH, Linker DT (1994) Incorporating the 4–chamber view of the fetal heart into the second trimester routine fetal examination. Ultrasound Obstet Gynecol 4: 24 – 28

    Article  Google Scholar 

  30. Chang TC, Robson SC, Boys RJ, Spencer JAD (1992) Prediction of the small for gestational age infant: Which ultrasonic measurement is best? Obstet Gynecol 80: 1030 – 1038

    PubMed  CAS  Google Scholar 

  31. David C, Tagliavini G, Pilu G, Rudenholz A, Bovicelli L (1996) Receiver–operator characteristic curves for the ultrasonographic prediction of small–for–gestational–age fetuses in low–risk pregnancies. Am J Obstet Gynecol 174: 1037 – 1042

    Article  PubMed  CAS  Google Scholar 

  32. Feige A, Rempen A, Würfel W, Caffier H, Jawny J (1996) Frauenheilkunde, S. 261–269. Urban & Schwarzenberg, München–Wien–Baltimore

    Google Scholar 

  33. Hansmann M (1981) Nachweis und Ausschluß fetaler Entwicklungsstörungen mittels Ultraschallscreening und gezielter Untersuchung – ein Mehrstufenkonzept. Ultraschall 2: 206 – 220

    Article  Google Scholar 

  34. Kassenrztliche Bundesvereinigung (1995) —nderung der Mutterschaftsrichtlinien. Dt –rztebl 92: B—233–B—235

    Google Scholar 

  35. Levi S, Schaaps JP, De Havay P, Coulon R, Defoort P (1995) End–result of routine ultrasound Screening for congenital anomalies: The Belgian multicentric study 1984–92. Ultrasound Obstet Gynecol 5: 366 – 371

    Article  PubMed  CAS  Google Scholar 

  36. Mai R, Rempen A, Kristen P (1995) Vaginalsonographie im 1. Trimenon zur Bestimmung des Geburtstermins. Frauenarzt 36: 681 – 688

    Google Scholar 

  37. Nicolaides KH, Brizot ML, Snijders RJM (1994) Fetal nuchal translucency: ultrasound Screening for fetal trisomy in the first trimester of pregnancy. Brit J Obstet Gynaecol 101: 782 – 786

    Article  CAS  Google Scholar 

  38. Pandya PP, Kondylios A, Hilbert L, Snijders RJM, Nicolaides KH (1995) Chromosomal defects and outcome in 1015 fetuses with increased nuchal translucency. Ultrasound Obstet Gynecol 5: 15 – 19

    Article  PubMed  CAS  Google Scholar 

  39. Rempen A (1996) Effizienz der Ultraschallbiometrie in der Schwangerschaft. Gynäkologe 29: 553 – 561

    Article  Google Scholar 

  40. Rempen A (1997) Ultraschall in der Frühschwangerschaft. In: Schmidt W (Hrsg): Jahrbuch der Gynäkologie und Geburtshilfe 1997/98. S. 51 – 61. Biermann, Zülpich

    Google Scholar 

  41. Wolfe HM, Zador IE, Bottoms SF, Treadwell MC, Sokol RJ (1993) Trends in Sonographie fetal organ visualization. Ultrasound Obstet Gynecol 3: 97 – 99

    Article  PubMed  CAS  Google Scholar 

  42. El–Rafaey H, Rajasekar D, Abdalla M, Calder L, Templeton A (1995) Induction of abortion with mifepristone and oral or vaginal misoprostol. N Engl J Med 332: 983 – 7

    Article  Google Scholar 

  43. El–Rafaey H, O’Brien P, Walder J, Rodeck C (1996) Misoprostol for third stage of labour. Lancet 347: 1257

    Google Scholar 

  44. 44; Ewart WR, Winikoff B (1998) Toward safe and effective medical abortion. Science 281: 520 – 1

    Article  Google Scholar 

  45. Fong YF, Singh K, Prasad RNV (1998) A comparative study using two dose regimens (200 jig or 400 jJLg) of vaginal misoprostol for pre–operative cervical dilatation in first trimester nulli– parae. Br J Obstet Gynaecol 105: 413 – 7

    Article  PubMed  CAS  Google Scholar 

  46. Jain JK, Mishell DR (1994) A comparison of intravaginal misoprostol with Prostaglandin E2 for termination of second–trimester pregnancy. N Engl J Med 331: 290 – 3

    Article  PubMed  CAS  Google Scholar 

  47. Pastuszak AL, Schüler M, Speckmartins CE, Coelho KE, Cordello SM, Vargas F, Brunoni D, Schwarz IV, Larrandaburu M, Safattle H, Meloni VF, Koren G (1998) Use of misoprostol during pregnancy and Möbius’ Syndrome in infants. N Engl J Med 338: 1881 – 5

    Article  PubMed  CAS  Google Scholar 

  48. Rabe T, Basse H, Thuro H, Kiesel L, Runnebaum B (1987) Wirkung des PGErMethylanalo– gons Misoprostol auf den schwangeren Uterus. Geburtsh u Frauenheilk 47: 324 – 31

    Article  CAS  Google Scholar 

  49. Sanchez–Ramos L, Kaunitz A, Wears RL, Delke I, Gaudier FL (1997) Misoprostol for cervi–cal ripening and labor induction: A meta–analysis. Obstet Gynecol 89: 633 – 42

    Article  Google Scholar 

  50. Surbek DV, Boesiger H, Hoesli I, Pavic N, Holzgreve W (1997) A double–blind comparison of the safety and efficacy of intravaginal misoprostol and Prostaglandin E2 to induce labor. Am J Obstet Gynecol 177: 1018 – 23

    Article  PubMed  CAS  Google Scholar 

  51. Walt RP (1992) Misoprostol for the treatment of peptic ulcer and antiinflammatory–drug– induced gastroduodenal ulceration (Review). N Engl J Med 327: 1575 – 80

    Article  PubMed  CAS  Google Scholar 

  52. Wing DA, Lovett K, Paul RH (1998) Disruption of prior uterine incision following misoprostol for labor induction in women with previous caesarean delivery. Obstet Gynecol 91: 828 – 30

    Article  PubMed  CAS  Google Scholar 

  53. Ziemann M, Fong S, Benowitz NL, Bankster D, Darney PD (1997) Absorption kinetics of misoprostol with oral or vaginal administration. Obstet Gynecol 90: 88 – 92

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Rath, W. et al. (2000). „Evidence-based medicine“ in der Geburtshilfe. In: Berg, D., Diedrich, K., Rauskolb, R. (eds) 52. Kongreß der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59688-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59688-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64085-8

  • Online ISBN: 978-3-642-59688-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics