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Klinische Symptomatik und natürlicher Krankheitsverlauf der Multiplen Sklerose

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Multiple Sklerose

Zusammenfassung

In Deutschland sind ca. 100–150 Patienten pro 100 000 Einwohner von der Multiplen Sklerose (MS) betroffen. Pro Jahr erkranken ca. 3000–5000 Patienten neu. Pathologisch anatomisch betrifft die MS zwar bevorzugt periventrikuläres Marklager, Sehnerv, Pons und zervikales Myelon, im Prinzip kann sie aber jede Struktur des zentralen Nervensystems (ZNS) befallen. Die Verteilung der Herde folgt keinem systematischen Muster, auch wenn es „typische“ Konstellationen gibt. Aus dieser Besonderheit resultiert die große Variabilität der klinischen Symptomatik. Nahezu jedes denkbare Symptom des ZNS kann auch im Rahmen der MS auftreten. Neben der Variabilität der Lokalisation der Herde bestimmt die Variabilität der zeitlichen Dynamik des Krankheitsprozesses den natürlichen Krankheitsverlauf, der beim individuellen Patienten nicht vorhersagbarist. Dennoch ist es für das Verständnis der Erkrankung und insbesondere für die praktische Betreuung der Patienten ungemein wichtig, sowohl das Spektrum der möglichen Symptome als auch die Grundsätze des natürlichen Krankheitsverlaufes zu kennen, auch wenn diese scheinbar einem „chaotischen“ Prinzip folgen.

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Authors
  1. A. Bitsch
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Editors and Affiliations

  1. Klinik und Poliklinik für Neurologie, Universität Rostock, Gehlsheimer Str. 20, 18055, Rostock, Germany

    Uwe K. Zettl  & Eilhard Mix PhD  & 

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© 2001 Springer-Verlag Berlin Heidelberg

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Bitsch, A. (2001). Klinische Symptomatik und natürlicher Krankheitsverlauf der Multiplen Sklerose. In: Zettl, U.K., Mix, E. (eds) Multiple Sklerose. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59453-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-59453-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41121-5

  • Online ISBN: 978-3-642-59453-3

  • eBook Packages: Springer Book Archive

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