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Aktuelle tierexperimentelle Aspekte der Multiple-Sklerose-Therapie

Antigenspezifische Immuntherapien bei Myelin-Oligodendrozyten-Glykoprotein-(MOG)-induzierter experimenteller autoimmuner Enzephalomyelitis

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Multiple Sklerose

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Zusammenfassung

Multiple Sklerose (MS) ist pathologisch durch scharf abgegrenzte demyelinisierte Läsionen im ZNS gekennzeichnet, die von T-Zellen und aktivierten Makrophagen infiltriert sind. Bis vor kurzem wurde diese Pathologie allein dem Effekt löslicher Moleküle zugeschrieben, die von den infiltrierenden inflammatorischen Zellen freigesetzt werden. In letzter Zeit wachsen aber die Hinweise auf mögliche zusätzliche Mechanismen. Sozeigten vor allem Untersuchungen von aktiv demyelinisierenden Läsionen,dass bei vielen Patienten myelinspezifische Antikörper an der Zerstörungder Markscheide beteiligt sind (Lucchinetti et al. 1996, 2000; Storch et al.1998 a; Genain et al. 1999). Dieser zusätzliche, B-Zell-abhängige Effektormechanismus hat natürlich einen großen Einfluss auf Entwicklung und Einsatz neuer Medikamente.

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Authors
  1. A. Schubart
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  2. Ch. Linington
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Editors and Affiliations

  1. Klinik und Poliklinik für Neurologie, Universität Rostock, Gehlsheimer Str. 20, 18055, Rostock, Germany

    Uwe K. Zettl  & Eilhard Mix PhD  & 

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© 2001 Springer-Verlag Berlin Heidelbers

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Schubart, A., Linington, C. (2001). Aktuelle tierexperimentelle Aspekte der Multiple-Sklerose-Therapie. In: Zettl, U.K., Mix, E. (eds) Multiple Sklerose. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59453-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-59453-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41121-5

  • Online ISBN: 978-3-642-59453-3

  • eBook Packages: Springer Book Archive

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