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Molecular Biology of Glycophorins of Human and Nonhuman Primates

  • Chapter
Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates

Abstract

The achievements in serology and immunogenetics described in the first part of this chapter provided evidence for the existence, incidence and polymorphism of MNSs blood group antigens in humans and nonhuman primates. Those antigens in all higher primates are products of the glycophorin A (GPA) gene family. The chemical structure of the human M, N, S and s genes is known, and the molecular basis for the common antigens and of a large number of variant alleles are understood (for reviews see: Cartron et al. 1990; Huang et al. 1991b; Fukuda 1993; Huang and Blumenfeld 1995; Blumenfeld and Huang 1995). Currently, information is accumulating on the structure and expression of homologous genes in nonhuman primates. That knowledge has already clarified and substantiated a number of serological observations, and its ramifications in the fields of human genetics, population diversity and evolution are to be anticipated.

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Authors
  1. O. O. Blumenfeld
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  2. C.-H. Huang
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  3. S. S. Xie
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  4. A. Blancher
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Editors and Affiliations

  1. Laboratoire d’Immunogénétique moléculaire, Université Paul Sabatier, CHU de Toulouse Hôpital Purpan, Place du Docteur Baylac, 31059, Toulouse cedex, France

    Antoine Blancher MD, PhD

  2. Max-Planck-Institut für Biologie Abteilung Immungenetik, Correnstr. 42, 72076, Tübingen, Germany

    Jan Klein PhD

  3. Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Fl, 33101, USA

    Jan Klein PhD

  4. Laboratory for Experimental Medicine and Surgery in Primates (LEMSIP), New York University Medical Center, 10 Townsend Avenue, Upper Grandview, NY, 10960-4830, USA

    Wladyslaw Socha MD

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Blumenfeld, O.O., Huang, CH., Xie, S.S., Blancher, A. (1997). Molecular Biology of Glycophorins of Human and Nonhuman Primates. In: Blancher, A., Klein, J., Socha, W. (eds) Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59086-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-59086-3_5

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