Abstract
Tumor stage and histological grading (low grade vs. high grade) determine the prognostic outcome of primary gastric mucosa-associated lymphoid tissue (MALT)-type non-Hodgkin’s lymphoma (NHL). Any diagnostic uncertainty of clinical staging may have potentially important therapeutic implications, especially if a non-surgical approach is favored. Diagnostic procedures for evaluation of gastric lymphoma include gastrointestinal endoscopy, endoscopic ultrasound of the upper gastrointestinal tract, conventional abdominal and cervical ultrasound, thoracic and abdominal computed tomography (CT) scans and bone marrow biopsy. In the present overview, the value of clinical diagnostic procedures is discussed with respect to clinical and endoscopic criteria which may be helpful for evaluation of gastric NHL. Furthermore, clinical staging methods such as endoscopie ultrasound are assessed which may allow pre-operative determination of tumor and lymph-node stage. These novel approaches are compared with the gold standard of pafhohistological analysis. In conclusion, the diagnostic procedures presented appear to be helpful for establishing an early diagnosis, however, innovative methods such as endoscopic-bioptic mapping of the stomach and ultrasound-guided fine-needle biopsy techniques may improve pre-therapeutical work-up.
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Azab MB, Henry-Amar M, Rougier P, Bognel C, Theodore C, Carde P, Lasser P, Cosset JM, Caillou B, Droz JP, Hayat M (1989) Prognostic factors in primary gastrointestinal non-Hodgkin’s lymphoma. A multivariant analysis, report of 106 cases, and review of the literature. Cancer 64:1208–1217
Brooks JJ, Enterline HT (1983) Primary gastric lymphomas-a clinicopathologic study of 58 cases with long-term follow-up and literature review. Cancer 51:701–711
Caletti G, Barbara L (1993) Gastric lymphoma: difficult to diagnose, difficult to stage? Endoscopy 25:528–530
Dawson IMP, Cornes JS, Morson BC (1961) Primary malignant lymphoid tmors of the intestinal tract. Br J Surg 49:80
Dragosics B, Bauer P, Radaskiewicz T (1985) Primary gastrointestinal non-Hodgkin’s lymphomas. A retrospective clinicopathological study of 150 cases. Cancer 55:1060–1073
Herrmann R, Panahon A, Barcos M, Walsh D, Stutzman L (1980) Occurrence and prognosis of extranodal lymphomas. Cancer 46:215–222
Isaacson P, Wright DH (1984) Extranodal malignant lymphoma arising from mucosaassociated lymphoid tissue. Cancer 53:2515–2524
Kolve ME, Fischbach W, Greiner A, Wilms K (1999) Differences in endoscopic and clinicopathological features of primary and secondary gastric non-Hodgkin’s lymphoma. Gastrointest Endosc 49:307–315
Lewine KJ, Ranchod M, Dorfman RF (1978) Lymphomas of the gastrointestinal tract — a study of 117 patients presenting with gastrointestinal disease. Cancer 42:693–707
Musshoff K (1977) Klinische Stadieneinteilung der Nicht-Hodgkin-Lymphome. Strahlentherapie 153:218–221
Otter R, Gerrits WBJ, Sandt MMVD, Hermans J, Willemze R (1989) Primary extranodal and nodal non-Hodgkin’s lymphoma. A survey of a population based registry. Eur J Cancer Clin Oncol 25:1203–1210
Radaskiewicz T, Dragosics B, Bauer P (1992) Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue: factors relevant for prognosis. Gastroenterology 102:1628–1638
Ruskoné-Fourmestraux A, Aegerter P, Delmer A, Brousse N, Galian A, Rambaud JC, and the Groupe d’Etude des Lymphomes Digestifs (1993) Primary digestive tract lymphoma: a prospective multicentric study of 91 patients. Gastroenterol 105:1662–1671
Seifert E, Schulte F, WeismuUer J, de Mas CR, Stolte M (1993) Endoscopie and bioptic diagnosis of malignant non-Hodgkin’s lymphoma of the stomach. Endoscopy 25:497–501
Severson RK, Davis S (1990) Increasing incidence of primary gastric lymphoma. Cancer 66:1283–1287
Strecker P, Eck M, Greiner A, Kolve M, Schmausser B, Marx A, Fischbach W, Fellbaum C, Müller-Hermelink HK (1998) Diagnostic value of stomach biopsy in comparison with surgical specimen in gastric B-cell lymphomas of the MALT type. Pathologe 19:209–213
Taal BG, Boot H, van Heerde P, de Jong D, Hart AAM, Burgers JMV (1996) Primary non-Hodgkin’s lymphoma of the stomach: endoscopie pattern and prognosis in low versus high-grade malignancy in relation to the MALT concept. Gut 39:556–561
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© 2000 Springer-Verlag Berlin Heidelberg
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Kolve, ME., Fischbach, W., Wilhelm, M. (2000). Primary Gastric Non-Hodgkin’s Lymphoma: Requirements for Diagnosis and Staging. In: Fischbach, W. (eds) Gastrointestinal Lymphoma. Recent Results in Cancer Research, vol 156. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57054-4_8
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DOI: https://doi.org/10.1007/978-3-642-57054-4_8
Publisher Name: Springer, Berlin, Heidelberg
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