Abstract
Marek’s disease (MD) is one of the most fascinating herpetic disorders because infection of susceptible chickens results in the rapid formation of T-cell lymphomas that are preventable by vaccination (Calnek and Witter 1997). For almost half a century, the commercial poultry industry has been dependent on effective MD vaccines. Because Marek’s disease virus (MDV) is a relatively difficult herpesvirus to study, information regarding it has lagged behind that for some other herpes-viruses. Latency is no exception to this general statement. MDV latency appears somehow connected to transformation, although the relationship between these two states is by no means clear. For example, it is not known whether latency is a precursor to transformation or whether it is a parallel manifestation of disease. In this review, I will attempt to define latency for MDV, describe systems in which it can be studied, review what is known about transcription during latency, and point out gaps in our existing understanding of this mode of infection.
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Keywords
- Parent Virus
- Latency Associate Transcript
- Pp38 Gene
- Latency Associate Transcript Promoter
- Iymphoblastoid Cell
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Morgan, R.W. et al. (2001). Marek’s Disease Virus Latency. In: Hirai, K. (eds) Marek’s Disease. Current Topics in Microbiology and Immunology, vol 255. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56863-3_9
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