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Genetic Vascular Embryology

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Pan Vascular Medicine

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Abstract

Cardiovascular malformations play a significant role in many hereditary and sporadic disorders. Commonly, these malformations result from perturbation of the developing vascular system. In this chapter, we review the general pathway by which the vasculature develops, and we discuss the etiology by which cardiovascular development or maintenance go awry. In addition to human disease, many such abnormalities are also observed in animals, including mice and zebrafish, the latter being an increasingly useful model in the study of the development of the vascular system. In many respects, morphogenesis in the vasculature (and the heart itself) presents challenges that are similar to corresponding events elsewhere in the body. Indeed, many of the diseases discussed here present with a range of effects in other tissues, demonstrating that some of the regulatory pathways are shared. However, blood flow is a unique characteristic of the cardiovascular system and, therefore, we will consider genetic and physiologic evidence that blood flow helps to shape these organs during development.

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Authors
  1. Jeffrey A. Towbin
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  2. John Belmont
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Editors and Affiliations

  1. Herz-Zentrum Coswig, Klinik für Kardiologie und Angiologie, Lerchenfeld 1, 06869, Coswig (Anhalt), Germany

    Peter Lanzer MD

  2. The Cleveland Clinic Foundation, One Clinic Center, 9500 Euclid Avenue, Cleveland, 44195, OH, USA

    Eric J. Topol MD

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© 2002 Springer-Verlag Berlin Heidelberg

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Towbin, J.A., Belmont, J. (2002). Genetic Vascular Embryology. In: Lanzer, P., Topol, E.J. (eds) Pan Vascular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56225-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-56225-9_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62565-7

  • Online ISBN: 978-3-642-56225-9

  • eBook Packages: Springer Book Archive

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