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Molecular Biology of Vascular Remodeling

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Pan Vascular Medicine

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Abstract

The earliest form of vascular remodeling occurs during embryonic development, during vascular formation. In this process endothelial cells arise and form a dense plexus throughout the mesoderm. This plexus then remodels to form a recognizable branching vascular pattern. This remodeling has been considered to be primarily an endothelial cell event. It is now increasingly clear that this earliest form of remodeling actually represents a complex coordinated development process involving endothelial cells and smooth muscle cells. Recent gene-targeting experiments have begun to dissect the signaling pathways that mediate various aspects of this complex process, which appears to be regulated by secreted factors and physical forces. Subsequently, there is extensive remodeling as the primitive vascular pattern reorganizes to reflect the definitive circulation found in higher vertebrates. And finally, there is continuous remodeling in embryogenesis and during postnatal development as the organism increases in size.

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  1. Philip S. Tsao
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  1. Herz-Zentrum Coswig, Klinik für Kardiologie und Angiologie, Lerchenfeld 1, 06869, Coswig (Anhalt), Germany

    Peter Lanzer MD

  2. The Cleveland Clinic Foundation, One Clinic Center, 9500 Euclid Avenue, Cleveland, 44195, OH, USA

    Eric J. Topol MD

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Tsao, P.S. et al. (2002). Molecular Biology of Vascular Remodeling. In: Lanzer, P., Topol, E.J. (eds) Pan Vascular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56225-9_15

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  • DOI: https://doi.org/10.1007/978-3-642-56225-9_15

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