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Local Muscularis Inflammatory Mechanisms of Ileus

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Mechanisms of Organ Dysfunction in Critical Illness

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICMSOFT,volume 38))

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Abstract

Ileus, signifying the impairment of coordinated propulsive intestinal peristalsis, remains a well-documented and virtually inevitable consequence of open abdominal surgery, sepsis, and shock. Despite the frequency and major impact of ileus on morbidity and mortality, little is known of the underlying cellular mechanisms of this important clinical conundrum. The major focus of our laboratory has been to investigate the immunological responses, which are initiated within the intestinal muscularis externa during abdominal surgery, sepsis, and shock. Here we summarize our recent findings on the molecular causes of ileus, using our rodent model, in which the small bowel is subjected to a minor degree of surgical manipulation consisting of simple inspection along its entire length using moist cotton applicators. Although, variations exist between postoperative trauma, sepsis and hemorrhagic shock, the general common principles elucidated here apply to all these initiating events which cause ileus. Because of space constraints, we have not tried to integrate the equally important findings made by other research groups.

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Authors and Affiliations

  1. Department of Medicine, University of Pittsburgh, S-849 Scaife Hall 3550 Terrace Street, Pittsburgh, PA, 15261, USA

    A. J. Bauer, J. C. Kalff & N. T. Schwarz

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  1. A. J. Bauer
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  2. J. C. Kalff
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  3. N. T. Schwarz
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Editors and Affiliations

  1. Intensive Care Unit, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Timothy W. Evans

  2. Division of Critical Care Medicine, University of Pittsburgh Medical Center, Scaife Hall, Room 606, 3550 Terrace Street, Pittsburgh, PA, 15264, USA

    Mitchell P. Fink

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© 2002 Springer-Verlag Berlin Heidelberg

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Bauer, A.J., Kalff, J.C., Schwarz, N.T. (2002). Local Muscularis Inflammatory Mechanisms of Ileus. In: Evans, T.W., Fink, M.P. (eds) Mechanisms of Organ Dysfunction in Critical Illness. Update in Intensive Care and Emergency Medicine, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56107-8_19

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  • DOI: https://doi.org/10.1007/978-3-642-56107-8_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42692-9

  • Online ISBN: 978-3-642-56107-8

  • eBook Packages: Springer Book Archive

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