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Regulated Intramembrane Proteolysis — New Lessons from Lipid Metabolism and the Unfolded Protein Response

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Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

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Abstract

Recent results from widely different fields of biological investigation have led to the recognition of a newly identified mechanism for intracellular signal transduction. This mechanism, termed Regulated mtramembrane proteolysis (Rip), involves the sequential cleavage of an integral membrane protein first within its extracytosolic domain followed by a second cleavage carried out by a different protease that can cleave within a membrane-spanning domain (Brown et al. 2000). This latter cleavage releases a soluble fragment to the cytosol. Where the function of the released soluble fragment is known, the fragment is involved in cellular signaling. Examples of Rip occur in both prokaryotes and eukaryotes, indicating that the phenomenon arose early in evolution. Here we consider recent results that shed additional light on the occurrence and mechanistic details of Rip.

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  1. R. B. Rawson
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Editors and Affiliations

  1. Fondation IPSEN, Pour la Recherche Thérapeutique, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen Ph. D.

  2. Institut Pasteur, Unité de Biologie Moléculaire de l’Expression Génique URA 1773 CNRS, 25 rue du Dr Roux, 75724, Paris Cedex 15, France

    Alain Israël Dr., Ph. D.

  3. Laboratory for Neuronal Cell Biology Center for Human Genetics, KUL-Gasthuisberg and Flanders Interuniversity Institute for Biotechnology, (VIB04) Herestraat 49, 3000, Leuven, Belgium

    Bart De Strooper Ph. D.

  4. Institut de Pharmacologie, Moléculaire et Cellulaire CNRS UPR 411, 660, route des Lucioles, Sophia Antipolis, Valbonne, 06560, France

    Frédéric Checler Ph. D.

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Rawson, R.B. (2002). Regulated Intramembrane Proteolysis — New Lessons from Lipid Metabolism and the Unfolded Protein Response. In: Christen, Y., Israël, A., De Strooper, B., Checler, F. (eds) Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55996-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-55996-9_1

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