Skip to main content

Zusammenfassung

Die Haut stellt eine Barriere dar, die uns vor schädlichen äußeren Einflüssen schützt und einen Flüssigkeitsverlust des Körpers verhindert. Sie besteht aus zwei Hauptschichten, der Epidermis (Oberhaut) und der darunterliegenden Dermis (Lederhaut). Die meisten Schutzfunktionen der Haut werden durch die Epidermis sichergestellt. Die Epidermis besteht aus 5 Schichten (Abb. 7.1): von aussen nach innen folgen das Stratum corneum (Hornschicht), das Stratum lucidum (diese Schicht findet sich nur in Bereichen des Körpers mit ziemlich dicker Haut), das Stratum granulosum, das Stratum spinosum und das Stratum basale [85]. Stammzellen im Stratum basale bilden ständig neue Zellen (Keratinozyten), die auf ihrer Wanderung nach oben zum Stratum corneum eine beträchtliche Differenzierung durchlaufen. Wenn die Zellen das Stratum corneum erreicht haben, sind sie abgeflacht und kernlos, enthalten eine grosse Menge an Keratin und Fetten und sie sind nicht mehr vital. Diese keratinreichen Zellen des Stratum corneum schützen das darunterliegende Gewebe vor äußeren Belastungen wie mechanischen Verletzungen, pH- und Temperaturänderungen sowie einer enzymatischen Verdauung. Die abgestorbenen Zellen des Stratum corneum, die als Korneozyten oder Horn-schuppen bezeichnet werden, schilfern sich beim Baden, Händewaschen und durch Reibung ab. Täglich werden circa 107 Partikel von der Haut abgestoßen. Demzufolge werden die Zellen der Epidermis alle zwei Wochen komplett erneuert [18, 52, 85].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 79.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Aly R and Maibach HI (1988) Comparative antibacterial efficacy of a 2-minute surgical scrub with Chlorhexidine gluconate, povidone-iodine, and chloroxylenol sponge-brushes. Am J Infect Control 16: 173–177

    Article  PubMed  CAS  Google Scholar 

  2. Aust LB and Maibach H (1980) Incidence of human skin sensitization to isostearyl alcohol in two separate groups of panelists. Contact Dermatitis 6: 269–271

    Article  PubMed  CAS  Google Scholar 

  3. Ayliffe GAJ, Babb JR, Quoraishi AH (1978) A test for „hygienic“hand disinfection. J Clin Pathol. 31: 923–928

    Article  PubMed  CAS  Google Scholar 

  4. Berardesca E, Vignoli GP, Distante F, Brizzi P, Rabbiosi G (1995) Effects of water temperature on surfactant-induced skin irritation. Contact Dermatitis 32: 83–87

    Article  PubMed  CAS  Google Scholar 

  5. Berkelman RL, Holland BW, Anderson RL (1982) Increased bactericidal activity of dilute preparations of povidone-iodine solutions. J Clin Microbiol 15: 635–639

    PubMed  CAS  Google Scholar 

  6. Berndt U, Wigger-Alberti W, Gabard B, Elsner P (2000) Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis. Contact Dermatitis 42: 77–80

    Article  PubMed  CAS  Google Scholar 

  7. Boyce JM (2001) Antiseptic technology: access, affordability and acceptance. Emerg Infect Diseases 7:231–233

    Article  CAS  Google Scholar 

  8. Boyce JM (2001) Scientific basis for handwashing with alcohol and other waterless antiseptic agents. In: Rutala WA (Hrsg.) Disinfection, sterilization and antisepsis: principles and practices in healthcare facilities. Association for Professionals in Infection Control and Epidemiology, Washington DC, 140–151

    Google Scholar 

  9. Boyce JM, Kelliher S, Vallande N (2000) Skin irritation and dryness associated with two hand hygiene regimens: soap and water handwashing versus hand antisepsis with an alcoholic hand gel. Infect Control Hosp Epidemiol 21: 442–448

    Article  PubMed  CAS  Google Scholar 

  10. Burke FJ, Wilson NH, Cheung SW (1995) Factors associated with skin irritation of the hands experienced by general dental practitioners. Contact Dermatitis 32: 35–38

    Article  PubMed  CAS  Google Scholar 

  11. De Groot AC (1987) Contact allergy to cosmetics: causative ingredients. Contact Dermatitis 17: 26–34

    Article  PubMed  Google Scholar 

  12. de Haan P, Meester HHM, Brynzeel DP (1996) Irritancy of alcohols. Van der Valk PGM, Maibach HI (Hrsg.) The irritant contact dermatitis syndrome. CRC press, New York, 65–70

    Google Scholar 

  13. Denton GW (1991) Chlorhexidine. In: Block SS (Hrsg): Disinfection, sterilization, and preservation. 4th ed. Lea & Febiger, Philadelphia, 274–289

    Google Scholar 

  14. Dineen P, Hildick-Smith G (1965) Antiseptic care of hands. In: Maibach HI, Hildick-Smith G (Hrsg.) Skin bacteria and their role in infection. McGraw-Hill, New York, 291–309

    Google Scholar 

  15. Dixon RE, Kaslow RA, Mackel DC, Fulkerson CC, Mallison GF (1976) Aqueous quaternary ammonium antiseptics and disinfectants. JAMA 236: 2415–2417

    Article  PubMed  CAS  Google Scholar 

  16. Emilson A, Lindbert M, Forslind B (1993) The temperature effect of in vitro penetration of sodium lauryl sulfate and nickel chloride through human skin. Acta Derm Venereol 73: 203–207

    PubMed  CAS  Google Scholar 

  17. Frosch PJ and Kligman AM (1979) The soap chamber test. J Am Acad Dermatol 1: 35–41

    Article  PubMed  CAS  Google Scholar 

  18. Fuchs E (1998) Beauty is skin deep: the fascinating biology of the epidermis and its appendages. Harvey Lect. 94: 47–77

    PubMed  Google Scholar 

  19. Funk JO and Maibach HI (1994) Propylene glycol dermatitis: re-evaluation of an old problem. Contact Dermatitis 31: 236–241

    Article  PubMed  CAS  Google Scholar 

  20. Garvey LH, Roed-Petersen J, Husum B (2001) Anaphylactic reactions in anaesthetised patients -four cases of Chlorhexidine allergy. Acta Anaesthesiol Scand 45: 1290–1294

    Article  PubMed  CAS  Google Scholar 

  21. Girard R, Amazian K, Fabry J (2001) Better compliance and better tolerance in relation to a well-conducted introduction to rub-in hand disinfection. J Hosp Infect 47: 131–137

    Article  PubMed  CAS  Google Scholar 

  22. Gravens DL, Butcher HR, Jr., Ballinger WF, Dewar NE (1973) Septisol antiseptic foam for hands of operating room personnel: an effective antibacterial agent. Surgery 73: 360–367

    PubMed  CAS  Google Scholar 

  23. Grove GL, Zerweck CR, Heilman JM, Pyrek JD (2001) Methods for evaluating changes in skin condition due to the effects of antimicrobial hand cleaners: two studies comparing a new waterless Chlorhexidine gluconate/ ethanol-emollient antiseptic preparation with a conventional water-applied product. Am J Infect Control 29: 361–369

    Article  PubMed  CAS  Google Scholar 

  24. Guin JD and Goodman J (2001) Contact urticaria from benzyl alcohol presenting as intolerance to saline soaks. Contact Dermatitis 45: 182–183

    Article  PubMed  CAS  Google Scholar 

  25. Hannuksela M (1996) Moisturizers in the prevention of contact dermatitis. In: Elsner P, Lachapelle JM, Wahlberg JE, Maibach HI (Hrsg.) Prevention of contact dermatitis - current problems in dermatology. Karger, Basel, 214–220

    Google Scholar 

  26. Hartstein AI, Denny MA, Morthland VH, LeMonte AM, Pfaller MA (1995) Control of methicillin-resistant Staphylococcus aureus in a hospital and an intensive care unit. Infect Control Hosp Epidemiol 16: 405–411

    Article  PubMed  CAS  Google Scholar 

  27. Hassing JH, Nater JP, Bleumink E (1982) Irritancy of low concentrations of soap and synthetic detergents as measured by skin water loss. Dermatologica 164: 314–321

    Article  PubMed  CAS  Google Scholar 

  28. Imokawa G, Akasaki S, Minematsu Y, Kawai M (1989) Importance of intercellular lipids in water-retention properties of the straum corneum: induction and recovery study of surfactant dry skin. Arch Dermatol Res 281: 45–51

    Article  PubMed  CAS  Google Scholar 

  29. Jemec GB and Serup J (1992) Scaling, dry skin and gender. A bioengineering study of dry skin. Acta Derm Venereol 177 (suppl): 26–28

    CAS  Google Scholar 

  30. Kiec-Swierczynska M, Krecisz B (2000) Occupational skin diseases among the nurses in the region of Lodz. Int J Occup Med Environ Health 13: 179–184

    PubMed  CAS  Google Scholar 

  31. Kirk JE (1966) Hand washing. Quantitative studies on skin lipid removal by soaps and detergents based on 1500 experiments. Acta Derm Venereol (Suppl 1) 183

    Google Scholar 

  32. Larson E, Friedman C, Cohran J, Treston-Aurand J, Green S (1997) Prevalence and correlates of skin damage on the hands of nurses. Heart Lung 26: 404–412

    Article  PubMed  CAS  Google Scholar 

  33. Larson E and Killien M (1982) Factors influencing handwashing behavior of patient care personnel. Am J Infect Control 10: 93–99

    Article  PubMed  CAS  Google Scholar 

  34. Larson E, Leyden JJ, McGinley KJ, Grove GL, Talbot GH (1986) Physiologic and microbiologic changes in skin related to frequent handwashing. Infect Control 7: 59–63

    PubMed  CAS  Google Scholar 

  35. Larson E, Silberger M, Jakob K, Whittier S, Lai L, Delia Latta P, Saiman L (2000) Assessment of alternative hand hygiene regimens to improve skin health among neonatal intensive care unit nurses. Heart Lung 29: 136–142

    Article  PubMed  CAS  Google Scholar 

  36. Larson E and Talbot GH (1986) An approach for selection of health care personnel handwashing agents. Infect Control 7: 419–424

    PubMed  CAS  Google Scholar 

  37. Larson EL, Aiello AE, Bastyr J, Lyle C, Stahl J, Cronquist A, Lai L, Della-Latta P (2001) Assessmant of two hand hygiene regimens for intensive care unit personnel. Crit Care Med 29; 944–951

    Article  PubMed  CAS  Google Scholar 

  38. Larson EL, Aiello AE, Heilman JM, Lyle CT, Cronquist A, Stahl JB (2001) Comparison of different regimens for surgical hand preparation. AORN J 73: 412–420

    Article  PubMed  CAS  Google Scholar 

  39. Larson EL, Butz AM, Gullette DL, Laughon BA (1990) Alcohol for surgical scrubbing? Infect Control Hosp Epidemiol 11: 139–143

    Article  PubMed  CAS  Google Scholar 

  40. Larson EL, Eke PI, Laughon BE (1986) Efficacy of alcohol-based hand rinses under frequent-use conditions. Antimicrob Agents Chemother 30: 542–544

    Article  PubMed  CAS  Google Scholar 

  41. Lowbury EJL, Lilly HA, Ayliffe GAJ (1974) Preoperative disinfection of surgeon’s hands: use of alcoholic solutions and effects of gloves on skin flora. Br Med J 4: 369–372

    Article  PubMed  CAS  Google Scholar 

  42. Lubbe J, Ruffieux C, Van Melle G, Perrenoud D (2001) Irritancy of the skin disinfectant n-propanol. Contact Dermatitis 45: 226–231

    Article  PubMed  CAS  Google Scholar 

  43. Maki DG (1989) The use of antiseptics for handwashing by medical personnel. J Chemother. 1 (Suppl): 3–11

    PubMed  Google Scholar 

  44. Maki DG, McCormick RD, Zilz MA, Stolz SM, Alvarado CJ (1990) An MRSA outbreak in a SICU during universal precautions: new epidemiology for nosocomial MRSA: downside for universal precautions. Program and abstracts of the 30th Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta, Abstr. #473:

    Google Scholar 

  45. Maury E, Alzieu M, Baudel JL, Haram N (2000) Availability of an alcohol solution can improve hand disinfection compliance in an intensive care unit. Am J Respir Crit Care Med 162: 324–327

    PubMed  CAS  Google Scholar 

  46. McCormick RD, Buchman TL, Maki D (2000) Double-blind, randomized trial of scheduled use of a novel barrier cream and an oil-containing lotion for protecting the hands of health care workers. Am J Infect Control 28: 302–310

    Article  PubMed  CAS  Google Scholar 

  47. Meranios JJ (1991) Quaternary ammonium antimicrobial compounds. In: Block SS (Hrsg): Disinfection, sterilization, and preservation. 4th ed. Lea & Febiger, Philadelphia, 225–255

    Google Scholar 

  48. Mitchell KG and Rawluk DJR (1984) Skin reactions related to surgical scrub-up: results of a Scottish survey. Br J Surg 71: 223–224

    Article  PubMed  CAS  Google Scholar 

  49. Mulberry G, Snyder AT, Heilman J, Pyrek J, Stahl J (2001) Evaluation of a waterless, scrubless Chlorhexidine gluconate/ethanol surgical scrub for antimicrobial efficacy. Am J Infect Control 29: 377–382

    Article  Google Scholar 

  50. Newman JL and Seitz JC (1990) Intermittent use of an antimicrobial hand gel for reducing soap-induced irritation of health care personnel. Am J Infect Control 18: 194–200

    Article  PubMed  CAS  Google Scholar 

  51. Nicoletti G, Boghossian V, Borland R (1990) Hygienic hand disinfection: a comparative study with Chlorhexidine detergents and soap. J Hosp Infect 15: 323–337

    Article  PubMed  CAS  Google Scholar 

  52. Noble WC (1975) Dispersal of skin microorganisms. Br J Dermatol 93: 477–485

    Article  PubMed  CAS  Google Scholar 

  53. Norlen L (2000) Skin barrier formation: the membrane folding model. J Invest Dermatol 117: 823–829

    Article  Google Scholar 

  54. Ohlenschlaeger J, Friberg J, Ramsing D, Agner T (1996) Temperature dependency of skin susceptibility to water and detergents. Acta Derm Venereol 76(4): 274–276

    PubMed  CAS  Google Scholar 

  55. Ojajarvi J (1976) An evaluation of antiseptics used for hand disinfection in wards. J Hyg (Camb) 76: 75–82

    Article  CAS  Google Scholar 

  56. Ojajarvi J (1981) The importance of soap selection for routine hand hygiene in hospital. J Hyg (Camb) 86: 275–283

    Article  CAS  Google Scholar 

  57. Ojajarvi J, Makela P, Rantasalo I (1977) Failure of hand disinfection with frequent hand washing: a need for prolonged field studies. J Hyg 79: 107–119

    Article  CAS  Google Scholar 

  58. Ollmar S, Nyren M, Nicander I, Lemtestam L (1994) Electrical impedance compared with other non-invasive bioengineering techniques and visual scoring for detection in irritation in human skin. Br J Dermatol 130: 29–36

    Article  PubMed  CAS  Google Scholar 

  59. Ophaswongse S and Maibach HI (1994) Alcohol dermatitis: allergic contact dermatitis and contact urticaria syndrome. Contact Dermatitis 30: 1–6

    Article  PubMed  CAS  Google Scholar 

  60. Parienti JJ, Thibon P, Heller R, Le Roux Y, von Theobald P, Bensadoun H, Bouvet A, Lemarchand F, Le Coutour X (2002) Hand-rubbing with an aqueous alcoholic solution vs traditional surgical hand-scrubbing and 30-day surgical site infection rates. A randomized equivalence study. JAMA 288; 722–727

    Article  PubMed  Google Scholar 

  61. Pereira LJ, Lee GM, Wade KJ (1997) An evaluation of five protocols for surgical handwashing in relation to skin condition and microbial counts. J Hosp Infect 36: 49–65

    Article  PubMed  CAS  Google Scholar 

  62. Perrenoud D, Bircher A, Hunziker T, Suter H, Bruckner-Tuderman L, Stager J, Thurlimann W, Schmid P, Suard A, Hunziker N (1994) Frequency of sensitization to 13 common preservatives in Switzerland. Swiss contact dermatitis research group. Contact Dermatitis 30: 276–279

    Article  PubMed  CAS  Google Scholar 

  63. Pham NH, Weiner JM, Reisner GS, Baldo BA (2000) Anaphylaxis to Chlorhexidine. Case report. Implication of immunoglobulin e antibodies and identification of an allergenic determinant. Clin Exp Allergy 30: 1001–1007

    Article  PubMed  CAS  Google Scholar 

  64. Podda M, Zollner T, Grundmann-Kollmann M, Kaufman R, Boehncke WF (1999) Allergic contact dermatitis from benzyl alcohol during topical antimycotic treatment. Contact Dermatitis 41: 302–303

    Article  PubMed  CAS  Google Scholar 

  65. Rosenberg A, Alatary SD, Peterson AF (1976) Safety and efficacy of the antiseptic Chlorhexidine gluconate. Surg Gynecol Obstet 143: 789–792

    PubMed  CAS  Google Scholar 

  66. Rotter M (1999) Hand washing and hand disinfection. In: Mayhall CG (Hrsg.) Hospital epidemiology and infection control. Lippincott Williams & Wilkins, Philadelphia, 1339–1355

    Google Scholar 

  67. Rotter ML, Koller W, Neumann R (1991) The influence of cosmetic additives on the acceptability of alcohol-based hand disinfectants. J Hosp Infect 18 (suppl B): 57–63

    Article  PubMed  Google Scholar 

  68. Sautter RL, Mattman LH, Legaspi RC (1984) Serratia marcescens meningitis associated with a contaminated benzalkonium chloride solution. Infect Control 5: 223–225

    PubMed  CAS  Google Scholar 

  69. Scheuplein R and Ross L (1970) Effects of surfactants and solvents on the permeability of epidermis. J Soc Cosmet Chem 21: 853–873

    CAS  Google Scholar 

  70. Scott D, Barnes A, Lister M, Arkell P (1991) An evaluation of the user acceptability of Chlorhexidine handwash formulations. J Hosp Infect 18: 51–55

    Article  PubMed  Google Scholar 

  71. Seitz JC and Newman JL (1988) Factors affecting skin condition in two nursing populations: Implications for current handwashing protocols. Am J Infect Control 16: 46–53

    Article  PubMed  CAS  Google Scholar 

  72. Simion FA, Rhein LD, Morrison BM, Jr., Scala DD, Salko DM, Kligman AM, Grove GL (1995) Self-perceived sensory responses to soap and synthetic detergent bars correlate with clinical signs of irritation. J Am Acad Dermatol 32: 205–211

    Article  PubMed  CAS  Google Scholar 

  73. Smit HA, Coenraads PJ, Lavrijsen PM, Nater JP (1992) Evaluation of a self-administered questionnaire on hand dermatitis. Contact Dermatitis 26: 11–16

    Article  PubMed  CAS  Google Scholar 

  74. Stingeni L, Lapomarda V, Lisi P (1995) Occupational hand dermatitis in hospital environments. Contact Dermatitis 33: 172–176

    Article  PubMed  CAS  Google Scholar 

  75. Tupker RA (1996) Detergents and cleansers. In: Van der Valk PGM, Maibach HI (Hrsg.) The irritant contact dermatitis syndrome. CRC press, New York, 71–76

    Google Scholar 

  76. Voss A and Widmer AF (1997) No time for handwashing!? Handwashing versus alcoholic rub: can we afford 100% compliance? Infect Control Hosp Epidemiol 18: 205–208

    Article  PubMed  CAS  Google Scholar 

  77. Walter CW (1965) Disinfection of hands. Am J Surg 109: 691–693

    Article  PubMed  CAS  Google Scholar 

  78. Warren R, Ertel KD, Bartolo RG, Levine M J, Bryant PB, Wong LF (1996) The influence of hard water (calcium) and surfactants on irritant contact dermatitis. Contact Dermatitis 35: 337–343

    Article  PubMed  CAS  Google Scholar 

  79. Wertz PW (2000) Lipids and barrier function of the skin. Acta Derm Venereol Supp 208: 7–11

    Article  CAS  Google Scholar 

  80. Widmer AF (2000) Replace hand washing with use of a waterless alcohol hand rub? Clin Infect Dis 31: 136–143

    Article  PubMed  CAS  Google Scholar 

  81. Wilhelm KP (1996) Prevention of surfactant-induced irritant contact dermatitis. In: Elsner P, Lachapelle JM, Wahlberg JE, Maibach HI (Hrsg.) Prevention of contact dermatitis - current problems in dermatology. Karger, Basel, 78–85

    Google Scholar 

  82. Wilhelm K-P, Freitag G, Wolff HH (1994) Surfactant-induced skin irritation and skin repair: evaluation of a cumulative human irritation model by noninvasive techniques. J Am Acad Dermatol 31:981–987

    Article  PubMed  CAS  Google Scholar 

  83. Winnefeld M, Richard MA, Drancourt M, Grobb JJ (2000) Skin tolerance and effectiveness of two hand decontamination procedures in everyday hospital use. Br J Dermatol 143: 546–550

    Article  PubMed  CAS  Google Scholar 

  84. Wong CSM and Beck MH (2001) Allergic contact dermatitis from triclosan in antibacterial handwashes. Contact Dermatitis 45: 307–307

    Article  PubMed  CAS  Google Scholar 

  85. Wysocki AB (1999) Skin anatomy, physiology, and pathophysiology. Nurs Clin North Am 34: 777–797

    PubMed  CAS  Google Scholar 

  86. Yesudian PD and King CM (2001) Allergic contact dermatitis from stearyl alcohol in efudix cream. Contact Dermatitis 45: 313–314

    Article  PubMed  CAS  Google Scholar 

  87. Zimakoff J, Kjelsberg AB, Larsen SO, Holstein B (1992) A multicenter questionnaire investigation of attitudes toward hand hygiene, assessed by the staff in fifteen hospitals in Denmark and Norway. Am J Infect Control 20: 58–64

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Boyce, J.M. (2003). Hautverträglichkeit. In: Kampf, G. (eds) Hände-Hygiene im Gesundheitswesen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55718-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-55718-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62908-2

  • Online ISBN: 978-3-642-55718-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics