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Hematopoietic Tissue II: Role of Colony-Stimulating Factors

  • Chapter
Modification of Radiation Response

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Colony-stimulating factors such as granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have started to alter traditional patterns of supportive care both in radiation oncology and in medical oncology. After results of numerous clinical trials, these factors are being marketed to reduce both acute and late normal tissue toxicity, for example in hematopoietic and mucosal tissues in the context of chemotherapy, extended-field radiotherapy, combined modality treatment and autologous bone marrow transplantation. Furthermore, some studies address their use in cancer patients in the perioperative setting.

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References

  • Abushullaih BA, Pestina TI, Srivastava DK et al (2001) A schedule of recombinant Mpl ligand is highly effective at preventing lethal myelosuppression in mice given carboplatin and radiation. Exp Hematol 29:1425–1431

    Article  PubMed  CAS  Google Scholar 

  • Akahori H, Ozai M, Ida M et al (1998) Further examination of various administration protocols of pegylated recombinant human megakaryocyte growth and development factor on thrombocytopenia in myelosuppressed mice. Ther Apher 2: 58–64

    Article  PubMed  CAS  Google Scholar 

  • Allouche M, Bikfalvi A (1995) The role of fibroblast growth factor-2 (FGF-2) in hematopoiesis. Prog Growth Factor Res 6:35–48

    Article  PubMed  CAS  Google Scholar 

  • Berghmans T, Paesmans M, Lafitte JJ et al (2002) Therapeutic use of granulocyte and granulocyte-macrophage colony-stimulating factor in febrile neutropenic cancer patients. A systematic review of the literature with meta-analysis. Support Care Cancer 10:181–188

    Article  PubMed  CAS  Google Scholar 

  • Borge OJ, Ramsfjell V, Cui L et al (1997) Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34+CD38-bone marrow cells with multilineage potential at the single-cell level: key role of thrombopoietin. Blood 90:2282–2292

    PubMed  CAS  Google Scholar 

  • Borrello I, Pardoll D (2002) GM-CSF-based cellular vaccines: a review of the clinical experience. Cytokine Growth Factor Rev 13:185–193

    Article  PubMed  CAS  Google Scholar 

  • Bretscher V, Andreutii D, Neuville P et al (2000) GM-CSF expression by tumor cells correlates with aggressivity and with stroma reaction formation. J Submicrosc Cytol Pathol 32:525–533

    PubMed  CAS  Google Scholar 

  • Brockstein B, Haraf DJ, Stenson K et al (2000) A phase I-II study of concomitant chemoradiotherapy with paclitaxel (one-hour infusion), 5-fluorouracil and hydroxyurea with granulocyte colony-stimulating factor support for patients with poor prognosis head and neck cancer. Ann Oncol 11: 721–728

    Article  PubMed  CAS  Google Scholar 

  • Bukowski RM, Budd GT, Gibbons JA et al (1994) Phase I trial of subcutaneous recombinant macrophage colony-stimulating factor: clinical and immunomodulatory effects. J Clin Oncol 12:97–106

    PubMed  CAS  Google Scholar 

  • Bunn BA Jr, Crowley J, Kelly K et al (1995) Chemoradiotherapy with or without granulocyte-macrophage colony-stimulating factor in the treatment of limited-stage small-cell lung cancer: a prospective phase III randomized study of the Southwest Oncology Group. J Clin Oncol 13:1632–1641

    PubMed  Google Scholar 

  • Burg J, Krump-Konvalinkova V, Bittinger F et al (2002) GM-CSF expression by human lung microvascular endothelial cells: in vitro and in vivo findings. Am J Physiol Lung Cell Mol Physiol 283:L460–L467

    PubMed  CAS  Google Scholar 

  • Chen Z, Malhotra PS, Thomas GR et al (1999) Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clin Cancer Res 5:1369–1379

    PubMed  CAS  Google Scholar 

  • Colombo MP, Ferrari G, Stoppacciaro A et al (1991) Granulocyte monocyte colony stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J Exp Med 173:889–897

    Article  PubMed  CAS  Google Scholar 

  • Diamantopoulos J, Pliotas G, Karageorgis P (2002) Treatment of post-radiation cystitis with intravesical administration of GM-CSF (abstract). Radiother Oncol 64[Suppl 1]:S306

    Google Scholar 

  • Ding I, Huang K, Snyder ML et al (1996) Tumor growth and radiosensitivity in mice given myeloprotective doses of fibroblast growth factors. J Natl Cancer Inst 88:1399–1404

    Article  PubMed  CAS  Google Scholar 

  • Ding I, Huang K, Wang X et al (1997) Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments. Acta Oncol 36:337–340

    Article  PubMed  CAS  Google Scholar 

  • Dranoff G, Jaffee E, Lazenby A et al (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulate potent specific and long lasting anti-tumor immunity. Proc Natl Acad Sci U S A 90:3539–3543

    Article  PubMed  CAS  Google Scholar 

  • Fedorocko P, Egyed A, Vacek A (2002) Irradiation induces increased production of hemopoietic and proinflammatory cytokines in the mouse lung. Int J Radiat Biol 78:305–313

    Article  PubMed  CAS  Google Scholar 

  • Finkelstein A, Makkar R, Doherty TM et al (2002) Increased expression of macrophage colony-stimulating factor after coronary artery balloon injury is inhibited by intracoronary brachytherapy. Circulation 105:2411–2415

    Article  PubMed  CAS  Google Scholar 

  • Fung SM, Ferrill MJ (2002) Granulocyte-macrophage colony-stimulating factor and oral mucositis. Ann Pharmacother 36:517–520

    Article  PubMed  CAS  Google Scholar 

  • Gabri MR, Menna PL, Scursoni AM et al (1999) Role of tumor-derived granulocyte-macrophage colony-stimulating factor in mice bearing a highly invasive and metastatic mammary carcinoma. Pathobiology 67:180–185

    Article  PubMed  CAS  Google Scholar 

  • Godwin JE, Kopecky KJ, Head DR et al (1998) A double-blind placebo-controlled trial of granulocyte colony-stimulating factor in elderly patients with previously untreated acute myelogenous leukaemia: a Southwest Oncology Group Study. Blood 91:3607–3615

    PubMed  CAS  Google Scholar 

  • Goodell MA, Rosenzweig M, Kim H et al (1997) Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 3:1337–1345

    Article  PubMed  CAS  Google Scholar 

  • Guenechea G, Gan OL, Dorrell C et al (2001) Distinct classes of human stem cells that differ in proliferative and self-renewal potential. Nat Immunol 2:75–82

    Article  PubMed  CAS  Google Scholar 

  • Heil G, Hoelzer D, Sanz M et al (1997) A randomized, double blind, placebo-controlled, phase III study of Filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukaemia. Blood 90: 4710–4718

    PubMed  CAS  Google Scholar 

  • Hirai K, Kumakiri M, Fujieda S et al (2001) Expression of granulocyte colony-stimulating factor and its receptor in epithelial skin tumors. J Dermatol Sci 25:179–188

    Article  PubMed  CAS  Google Scholar 

  • Howiecki J, Giebel S, Krzemien S et al (2002) G-CSF administered in time-sequenced setting during remission induction and consolidation therapy of adult acute lymphoblastic leukemia has beneficial influence on early recovery and possibly improves long-term outcome: a randomized multicenter study. Leuk Lymph 43:315–325

    Article  Google Scholar 

  • Hubel K, Dale DC, Liles WC (2002) Therapeutic use of cytokines to modulate phagocyte function for the treatment of infectious diseases: current status of G-CSF, GM-CSF, M-CSF, and INF-gamma. J Infect Dis 185:1490–1501

    Article  PubMed  CAS  Google Scholar 

  • Huttmann A, Liu SL, Boyd AW et al (2001) Functional heterogeneity within rhodamine123(Io) Hoechst33342(Io/sp) primitive hemopoietic stem cells revealed by pyronin. Exp Hematol 29:1109–1116

    Article  PubMed  CAS  Google Scholar 

  • Ichiishi E, Yoshikawa T, Kogawa T et al (2000) Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony-stimulating factor produced by squamous cell carcinoma of the oesophagus. Gut 46: 432–434

    Article  PubMed  CAS  Google Scholar 

  • Kimby E (2002) Beyond immunochemotherapy: combinations of rituximab with cytokines interferon-alpha2a and granulocyte-macrophage colony-stimulating factor. Semin Oncol 29[Suppl 6]:7–10

    Article  PubMed  CAS  Google Scholar 

  • Knospe W, Blom J, Crosby W (1966) Regeneration of locally irradiated bone marrow I. Dose-dependent, long-term changes in the rat, with particular emphasis upon vascular and stromal reaction. Blood 28:1653–1668

    Google Scholar 

  • Kouvaris JR, Kouloulias VE, Plantaniotis GA et al (2001) Dermatitis during radiation for vulvar carcinoma: prevention and treatment with granulocyte-macrophage colony-stimulating factor impregnated gauze. Wound Repair Regen 9: 187–193

    Article  PubMed  CAS  Google Scholar 

  • Langer CJ, Movsas B, Hudes R et al (1997) Induction paclitaxel and carboplatin followed by concurrent chemora-diotherapy in patients with unresectable, locally advanced non-small cell lung carcinoma. Semin Oncol 24[Suppl 12]: 89–95

    CAS  Google Scholar 

  • Liu W, Wang M, Tang DC et al (1999) Thrombopoietin has a differentiative effect on late-stage human erythropoiesis. Br J Haematol 105:459–469

    Article  PubMed  CAS  Google Scholar 

  • Löffler H, Rastetter J (1999) Atlas der klinischen Hämatologie, 5th edn (German). Springer, Berlin Heidelberg New York

    Google Scholar 

  • Lyman GH, Kuderer NM, Djulbegovic B (2002) Prophylactic granulocyte colony-stimulating factor in patients receiving dose-intensive cancer chemotherapy: a meta-analysis. Am JMed 112:406–411

    CAS  Google Scholar 

  • Makkonen TA, Minn H, Jekunen A (2000) Granulocyte macrophage colony-stimulating factor and sucralfate in prevention of radiation-induced mucositis: a prospective randomized study. Int J Radiat Oncol Biol Phys 46:525–534

    Article  PubMed  CAS  Google Scholar 

  • Mauch P, Constine L, Greenberger J et al (1995) Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy. Int J Radiat Oncol Biol Phys 31:1319–1339

    Article  PubMed  CAS  Google Scholar 

  • Merogi AJ, Marrogi AJ, Ramesh R et al (1997) Tumor-host interaction: analysis of cytokines, growth factors, and tumor-infiltrating lymphocytes in ovarian carcinomas. Hum Pathol 28:321–331

    Article  PubMed  CAS  Google Scholar 

  • Minasian LM, Yao TJ, Steffens TA et al (1995) A phase I study of anti-GD3 ganglioside monoclonal antibody R24 and recombinant human macrophage-colony stimulating factor in patients with metastatic melanoma. Cancer 75: 2251–2257

    Article  PubMed  CAS  Google Scholar 

  • Miyazaki H (1998) Update on thrombopoietin in preclinical and clinical trials. Curr Opin Hematol 5:197–202

    Article  PubMed  CAS  Google Scholar 

  • Mouthon MA, van der Meeren A, Vandamme M et al (2001) A single administration of thrombopoietin to lethally irradiated mice prevents the infectious and thrombotic events leading to mortality. Exp Hematol 29:30–40

    Article  PubMed  CAS  Google Scholar 

  • Müller MM, Herold-Mende CC, Riede D et al (1999) Autocrine growth regulation by granulocyte macrophage colony-stimulating factor in human gliomas with tumor progression. Am J Pathol 155:1557–1567

    Article  Google Scholar 

  • Neelis KJ, Quingliang L, Thomas GR et al (1997a) Prevention of thrombocytopenia by thrombopoietin in myelosuppressed rhesus monkeys accompanied by prominent erythropoietic stimulation and iron depletion. Blood 90:58–63

    PubMed  CAS  Google Scholar 

  • Neelis KJ, Dubbelman YD, Quingliang L et al (1997b) Simultaneous TPO and G-CSF treatment of rhesus monkeys prevents thrombopenia, accelerates platelet and red cell reconstitution, alleviates neutropenia and promotes the recovery of immature bone marrow cells. Exp Hematol 25:1084–1093

    PubMed  CAS  Google Scholar 

  • Neelis KJ, Hartong SC, Egeland T et al (1997c) The efficacy of single-dose administration of thrombopoietin with coadministration of either granulocyte/macrophage or granulocyte colony-stimulating factor in myelosuppressed rhesus monkeys. Blood 90:2555–2564

    Google Scholar 

  • Neelis KJ, Visser TP, Dimjati W et al (1998) A single dose of thrombopoietin early after myelosuppressive total body irradiation prevents pancytopenia by promoting shortterm multilineage spleen repopulating cells at the transient expense of bone marrow repopulating cells. Blood 92: 1586–1597

    PubMed  CAS  Google Scholar 

  • Nestle FO, Alijagic S, Gilliet M et al (1998) Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells. Nat Med 4:328–332

    Article  PubMed  CAS  Google Scholar 

  • Neta R (1997) Modulation of radiation damage by cytokines. Stem Cells 15[Suppl 2]:87–94

    PubMed  CAS  Google Scholar 

  • Neta R, Oppenheim JJ, Douches SD (1988) Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor. J Immunol 140:108–111

    PubMed  CAS  Google Scholar 

  • Noda I, Fujieda S, Ohtsubo T et al (1999) Granulocyte colony-stimulating factor enhances invasive potential of human head and neck carcinoma cell lines. Int J Cancer 80:78–84

    Article  PubMed  CAS  Google Scholar 

  • Ohno R, Naoe T, Kanamaru A et al (1994) The Kohseisho Leukemia Study Group: a double blind controlled study of granulocyte colony-stimulating factor started two days before induction chemotherapy in refractory acute myeloid leukaemia. Blood 83:2086–2092

    PubMed  CAS  Google Scholar 

  • Okamoto R, Yajima T, Yamazaki M et al (2002) Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nature Med 8:1011–1017

    Article  PubMed  CAS  Google Scholar 

  • Parmentier C, Morardet N, Tubiana M (1983) Late effects on human bone marrow after extended field radiotherapy. Int J Radiat Oncol Biol Phys 9:1303–1311

    Article  PubMed  CAS  Google Scholar 

  • Pui CTL, Boyett JM, Hughes WT et al (1997) Human granulocyte colony-stimulating factor after induction chemotherapy in children with acute lymphoblastic leukaemia. N Engl J Med 336:1781–1787

    Article  PubMed  CAS  Google Scholar 

  • Rowe JM, Andersen JW, Mazza JJ et al (1995) A randomized placebo-controlled phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (>55 to 70 years of age) with acute myelogenous leukaemia: a study of the Eastern Cooperative Oncology Group. Blood 86:457–462

    PubMed  CAS  Google Scholar 

  • Sacks E, Goris M, Glatstein E et al (1978) Bone marrow regeneration following large field radiation. Influence of volume, age, dose, and time. Cancer 42:1057–1065

    Article  PubMed  CAS  Google Scholar 

  • Simons JW, Jaffee EM, Weber CE et al (1997) Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Res 57:1537–1546

    PubMed  CAS  Google Scholar 

  • Sitnicka E, Lin N, Priestley GV et al (1996) The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 87:4998–5005

    PubMed  CAS  Google Scholar 

  • Sprinzl GM, Galvan O, de Vries A et al (2001) Local application of granulocyte-macrophage colony stimulating factor for the treatment of oral mucositis. Eur J Cancer 37: 2003–2009

    Article  PubMed  CAS  Google Scholar 

  • Staar S, Rudat V, Stützer H et al (2001) Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy — results of a multicenter randomized German trial in advanced head and neck cancer. Int J Radiat Oncol Biol Phys 50:1161–1171

    Article  PubMed  CAS  Google Scholar 

  • Stone RM, Berg DT, George SL et al (1995) Granulocyte-macrophage colony-stimulating factor after initial chemotherapy for elderly patients with primary acute myelogenous leukemia. N Engl J Med 332:1671–1677

    Article  PubMed  CAS  Google Scholar 

  • Sugimoto M, Kajimura M, Hanai H et al (1999) G-CSF-producing gastric anaplastic large cell lymphoma complicating esophageal cancer. Dig Dis Sci 44:2035–2038

    Article  PubMed  CAS  Google Scholar 

  • Sugimoto C, Fujieda S, Sunaga H et al (2001) Granulocyte colony-stimulating factor-mediated signalling regulates type IV collagenase activity in head and neck cancer cells. Int J Cancer 93:42–46

    Article  PubMed  CAS  Google Scholar 

  • Sunaga H, Fujieda S, Tsuzuki H et al (2001) Expression of granulocyte colony-stimulating factor receptor and platelet-derived endothelial cell growth factor in oral and oropharyngeal precancerous lesions. Anticancer Res 21: 2901–2906

    PubMed  CAS  Google Scholar 

  • Tachibana M, Miyakawa A, Tazaki H et al (1995) Autocrine growth of transitional cell carcinoma of the bladder induced by granulocyte-colony stimulating factor. Cancer Res 55:3438–3443

    PubMed  CAS  Google Scholar 

  • Teicher BA, Ara G, Menon K et al (1996) In vivo studies with interleukin-12 alone and in combination with monocyte colony-stimulating factor and/or fractionated radiation treatment. Int J Cancer 65:80–84

    Article  PubMed  CAS  Google Scholar 

  • Thacker JD, Dedhar S, Hogge DE (1994) The effect of GM-CSF and G-CSF on the growth of human osteosarcoma cells in vitro and in vivo. Int J Cancer 56:236–243

    Article  PubMed  CAS  Google Scholar 

  • Trapnell BC, Whitsett JA (2002) GM-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense. Annu Rev Physiol 64:775–802

    Article  PubMed  CAS  Google Scholar 

  • Tsuzuki H, Fujieda S, Sunaga H et al (1998) Expression of granulocyte colony-stimulating factor receptor correlates with prognosis in oral and mesopharyngeal carcinoma. Cancer Res 58:794–800

    PubMed  CAS  Google Scholar 

  • Van der Meeren A, Mouthon MA, Gaugler MH et al (2002) Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: interactive effect with thrombopoietin. Radiat Res 157:642–649

    Article  PubMed  Google Scholar 

  • Vokes EE, Haraf DJ, Mick R et al (1994) Intensified concomitant chemoradiotherapy with and without filgrastim for poor-prognostic head and neck cancer. J Clin Oncol 12: 2351–2359

    PubMed  CAS  Google Scholar 

  • Welte K, Reiter A, Mempel K et al (1996) A randomized phase III study of the efficacy of granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukaemia. Blood 87:3143–3150

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, 81675, Munich, Germany

    C. Nieder MD, B. Jeremic MD & F. B. Zimmermann MD

  2. Department of Hematology and Medical Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, 81675, Munich, Germany

    T. Licht MD

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  1. C. Nieder MD
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  2. B. Jeremic MD
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  3. F. B. Zimmermann MD
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Editors and Affiliations

  1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Carsten Nieder MD

  2. Department of Experimental Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    Luka Milas MD, PhD

  3. Department of Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    K. Kian Ang MD, PhD

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Nieder, C., Jeremic, B., Zimmermann, F.B., Licht, T. (2003). Hematopoietic Tissue II: Role of Colony-Stimulating Factors. In: Nieder, C., Milas, L., Ang, K.K. (eds) Modification of Radiation Response. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55613-5_8

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  • DOI: https://doi.org/10.1007/978-3-642-55613-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62670-8

  • Online ISBN: 978-3-642-55613-5

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