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Mechanisms and Modification of the Radiation Response of Gastrointestinal Organs

  • Chapter
Modification of Radiation Response

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The alimentary canal extends from the mouth to the anus. It comprises the upper aerodigestive tract (oral cavity and pharynx), the esophagus, and the gastrointestinal (GI) tract proper (stomach, duodenum, jejunum, ileum, colon, rectum, and anus). In radiation therapy, toxicities of the small intestine, colon, and rectum are more important in terms of quantitative and clinical significance than toxicities of the proximal GI tract. Therefore, this review will largely address the radiation response of the small bowel, colon, and rectum. Although the mechanisms and pathophysiology of radiation injury in these segments of the GI tract are similar in many respects, there are also anatomical and physiological differences that result in unique features of radiation toxicity and strategies for modulation in each segment.

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  1. Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, 72205, AR, USA

    M. Hauer-Jensen MD, PhD & J. Wang MD, PhD

  2. Department of Radiation Oncology, Newcastle University, Newcastle, NSW, Australia

    J. W. Denham MD

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  1. M. Hauer-Jensen MD, PhD
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  2. J. Wang MD, PhD
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  3. J. W. Denham MD
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  1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Carsten Nieder MD

  2. Department of Experimental Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    Luka Milas MD, PhD

  3. Department of Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    K. Kian Ang MD, PhD

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Hauer-Jensen, M., Wang, J., Denham, J.W. (2003). Mechanisms and Modification of the Radiation Response of Gastrointestinal Organs. In: Nieder, C., Milas, L., Ang, K.K. (eds) Modification of Radiation Response. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55613-5_5

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