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Role of Radiation-Induced Signaling Proteins in the Response of Vascular and Connective Tissues

  • Chapter
Modification of Radiation Response

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Over the years considerable effort has been made not only to quantify the tolerance of normal tissue to radiation, but also to provide a baseline for radiotherapy at maximum biological effective doses. Normal tissue complications induced by ionizing radiation differ depending on the target organ and cell types. Acute or early reactions are primarily characterized by rapidly occurring changes within hours, such as increased endothelial cell swelling, vascular permeability and edema as well as lymphocyte adhesion and infiltration. Apoptosis of endothelial cells is probably the most important feature in the concert of these radiation-induced acute alterations in the vascular system of irradiated organs. Thus, acute reactions are primarily reflected by the rates of radiation-induced cell death and regeneration by surviving stem cells.

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Authors and Affiliations

  1. Section of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard-Karls University, Tübingen, Röntgenweg 11, 72076, Tübingen, Germany

    H. P. Rodemann PhD (Professor)

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  1. H. P. Rodemann PhD
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Editors and Affiliations

  1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Carsten Nieder MD

  2. Department of Experimental Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    Luka Milas MD, PhD

  3. Department of Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    K. Kian Ang MD, PhD

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© 2003 Springer-Verlag Berlin Heidelberg

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Rodemann, H.P. (2003). Role of Radiation-Induced Signaling Proteins in the Response of Vascular and Connective Tissues. In: Nieder, C., Milas, L., Ang, K.K. (eds) Modification of Radiation Response. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55613-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-55613-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62670-8

  • Online ISBN: 978-3-642-55613-5

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