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Role of Epidermal Growth Factor Receptor and Its Inhibition in Radiotherapy

  • Chapter
Modification of Radiation Response

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Growth factors are substances that regulate cell growth and proliferation, and maintain architectural and functional homeostasis in normal tissues. They bind to specific cell membrane receptors setting in motion a highly regulated network of cellular events, signal transduction, gene activation, transcription, etc., which then regulate cell cycle checkpoints. Growth factors act locally by autocrine or paracrine functions or on distant tissues via endocrine activities. Over a hundred different growth factors have been identified, many of which interact with each other rendering complimentary or opposing effects on cell growth. Compared to normal tissues, growth factor signaling pathways in tumors are commonly subverted to result in inordinate division and function of cells. Tumors, which are composed of both malignant cells and many types of normal cells that infiltrate tumors, including endothelial cells, fibroblasts and lymphoid cells, secrete a variety of growth factors, which regulate tumor growth and dissemination. Comparable to their action in normal tissues, these factors can be autocrine, paracrine or affect cells at a distance from their production site and may have complementary or opposing effects on tumor cell growth.

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Authors and Affiliations

  1. Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030-4009, USA

    L. Milas MD, PhD, K. A. Mason MD, Z. Fan MD & K. K. Ang MD, PhD

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  1. L. Milas MD, PhD
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  2. K. A. Mason MD
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  3. Z. Fan MD
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  4. K. K. Ang MD, PhD
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  1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Carsten Nieder MD

  2. Department of Experimental Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    Luka Milas MD, PhD

  3. Department of Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    K. Kian Ang MD, PhD

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Milas, L., Mason, K.A., Fan, Z., Ang, K.K. (2003). Role of Epidermal Growth Factor Receptor and Its Inhibition in Radiotherapy. In: Nieder, C., Milas, L., Ang, K.K. (eds) Modification of Radiation Response. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55613-5_15

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  • DOI: https://doi.org/10.1007/978-3-642-55613-5_15

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