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The Potential Role of Signaling Proteins in the Acceleration of Repopulation in Normal and Malignant Tissues

  • Chapter
Modification of Radiation Response

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

  • 142 Accesses

Abstract

Repopulation is defined as a net increase in stem cell number during cancer treatment, in particular during a course of radiotherapy. (2000) recently discussed the importance of repopulation between cycles of chemotherapy, a topic which will not be reviewed here. Since stem cells cannot be identified morphologically, or by molecular methods, they cannot be counted directly. Therefore, they have to be measured by the influence the quantitative destruction of stem cells by radiation has on clinical radiation damage. For the same severity of radiation injury, the tolerated radiation dose or the mean curative radiation dose TCD50 (corrected for fractionation effects using the linear quadratic equation, e.g., by calculating the biologically effective dose (BED) (Shirazi et al. 1995) increases in proportion to the logarithm of the increase in the number of stem cells produced during irradiation.

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Authors and Affiliations

  1. St. Bartholomew’s Medical College QMW, Charterhouse Square, London, EC1M 6BQ, UK

    K.-R. Trott MD (Professor)

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  1. K.-R. Trott MD
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Editors and Affiliations

  1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Carsten Nieder MD

  2. Department of Experimental Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    Luka Milas MD, PhD

  3. Department of Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    K. Kian Ang MD, PhD

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© 2003 Springer-Verlag Berlin Heidelberg

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Trott, KR. (2003). The Potential Role of Signaling Proteins in the Acceleration of Repopulation in Normal and Malignant Tissues. In: Nieder, C., Milas, L., Ang, K.K. (eds) Modification of Radiation Response. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55613-5_1

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  • DOI: https://doi.org/10.1007/978-3-642-55613-5_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62670-8

  • Online ISBN: 978-3-642-55613-5

  • eBook Packages: Springer Book Archive

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