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Immune Activity and Vitamin D

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Filaggrin

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Abstract

Atopic diseases are characterized by elevated levels of IgE and classically described as Th2 mediated. However, during the last years it has become clear that several other players also are important for the immune responses during atopic dermatitis. Among these are epithelial cells, innate lymphoid cells (ILCs), Th17 cells, and vitamin D. This chapter focuses on the role of these during the immune response to allergens and how the lack of filaggrin affects these mechanisms. Both human and mice studies are discussed because much of the knowledge about the effects of filaggrin on the immune system comes from studies using the Flaky tail mice (Flgft mice) lacking filaggrin.

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Authors and Affiliations

  1. Department of International Health, Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3, Copenhagen, 2200, Denmark

    Charlotte M. Bonefeld PhD, Morten M. Nielsen MS & Carsten Geisler MD, PhD, DMSc

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  1. Charlotte M. Bonefeld PhD
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  2. Morten M. Nielsen MS
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  3. Carsten Geisler MD, PhD, DMSc
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Correspondence to Charlotte M. Bonefeld PhD .

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Editors and Affiliations

  1. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

  2. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Bonefeld, C.M., Nielsen, M.M., Geisler, C. (2014). Immune Activity and Vitamin D. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-54379-1_5

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