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Uveal Malignant Melanoma: The Collaborative Ocular Melanoma Study

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Clinical Ophthalmic Oncology

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Abstract

Until the 1980s, most studies on the treatment of uveal melanoma were retrospective and included only small numbers of patients treated at a given center. The optimal management for uveal melanomas—small, medium, or large—was debatable, and the benefit of enucleation was being questioned. Therefore, in 1984, at the request of Dr. Kupfer, Director of the National Eye Institute (Bethesda, Maryland), the Collaborative Ocular Melanoma Study (COMS) trials were designed. Funding was obtained from the National Eye Institute. In this review we summarize the main objectives, significant design features, and major findings of the COMS.

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Author information

Authors and Affiliations

  1. Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Carlos Medina MD & Arun D. Singh MD

  2. Department of Ophthalmology, Helsinki University Central Hospital, Haartmaninkatu 4C, PL 220, FIN-00029 HUS, Helsinki, Finland

    Tero Kivelä MD, FEBO

Authors
  1. Carlos Medina MD
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  2. Arun D. Singh MD
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  3. Tero Kivelä MD, FEBO
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Corresponding author

Correspondence to Arun D. Singh MD .

Editor information

Editors and Affiliations

  1. Ocular Oncology Service, Departments of Ophthalmology and Radiation Oncology, University of California, San Francisco, San Francisco, California, USA

    Bertil Damato

  2. Dept. of Ophthalmic Oncology, Cole Eye Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Arun D. Singh

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© 2014 Springer-Verlag Berlin Heidelberg

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Medina, C., Singh, A.D., Kivelä, T. (2014). Uveal Malignant Melanoma: The Collaborative Ocular Melanoma Study. In: Damato, B., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54255-8_18

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  • DOI: https://doi.org/10.1007/978-3-642-54255-8_18

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54254-1

  • Online ISBN: 978-3-642-54255-8

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