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Behandlung der Hypertonie mit Angiotensin II AT1-Rezeptorantagonisten

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Angiotensin II AT1-Rezeptorantagonisten

Zusammenfassung

Unkontrollierte persistierende Blutdruckerhöhungen stellen einen der wichtigsten unabhängigen Hauptrisikofaktoren für zerebrovaskuläre Schädigungen , kardiale Komplikationen und fortgeschrittene Nierenerkrankung dar. Eine adäquate medikamentöse Behandlung des Bluthochdrucks führte zu einer deutlichen Reduktion der kardiovaskulären Mortalität und Morbidität (14, 30). Neue Ergebnisse der Framingham-Studien von mittlerweile über 20 Jahre „follow-up“ weisen darauf hin, daß eine Langzeitbehandlung mit Antihypertensiva noch viel mehr gegen kardiovaskuläre Morbidität und Mortalität schützt, als es frühere Ergebnisse aus klinischen Untersuchungen haben vermuten lassen (34). Die höchste Gesamtüberlebenszeit war bei Männern mit einem systolischen Blutdruck von weniger als 134 mmHg unter antihypertensiver Behandlung assoziiert, bei Frauen weniger als 149 mmHg systolisch und für beide Geschlechter mit einem diastolischen Blutdruck von weniger als 95 mmHg (6). Eine Metaanalyse von 14 randomisierten klinischen Studien konnte eine 42 % ige Reduktion der Inzidenz für Schlaganfälle bei einer Abnahme des diastolischen Blutdrucks von 5 – 6 mmHg feststellen (14). Die Abnahme der Schlaganfallrate war in einem vergleichbaren Umfang übereinstimmend in Langzeitbeobachtungsstudien festgestellt worden, in denen bei einer entsprechenden Blutdruckabnahme eine 35 – 40 %ige Abnahme der Schlaganfallereignisse zu verzeichnen war. Zusammenfassend unterstreichen die dargestellten Ergebnisse die Notwendigkeit, eine antihypertensive Therapie konsequent durchzuführen.

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Authors and Affiliations

  1. Medizinische Klinik 4, Klinikum Süd, Universität Erlangen-Nürnberg, Breslauer Straße 201, 90471, Nürnberg, Germany

    Prof. Dr. med. Roland E. Schmieder

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  1. Prof. Dr. med. Roland E. Schmieder
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  2. J. K. Rockstroh
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Editors and Affiliations

  1. Institut für Pharmakologie, Universität zu Lübeck, Ratzeburger Allee 160, D-23538, Lübeck, Deutschland

    P. Dominiak

  2. Institut für Pharmakologie, Klinikum der Christian-Albrechts-Universität zu Kiel, Hospitalstraße 4, D-24105, Kiel, Deutschland

    Thomas Unger

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Schmieder, R.E., Rockstroh, J.K. (1997). Behandlung der Hypertonie mit Angiotensin II AT1-Rezeptorantagonisten. In: Dominiak, P., Unger, T. (eds) Angiotensin II AT1-Rezeptorantagonisten. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-53757-8_3

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  • DOI: https://doi.org/10.1007/978-3-642-53757-8_3

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-53758-5

  • Online ISBN: 978-3-642-53757-8

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