Abstract
Continuous fluxes of cytoplasm and membrane material are required to sustain cell locomotion. In some examples, e. g. epidermal cells of various vertebrates very small changes in the overall morphology of the cells take place during locomotion, in others e. g. fibroblasts or lymphocytes, at least the general appearance remains unaltered. Thus any model on cell locomotion has to include the continuous organization and disorganization of cell architecture under steady state conditions. Such a model is presented, based on intracellular pressure differences providing the source for the motive force and on the distribution of cytoskeletal elements providing the structural basis for force generation and cell shape. A detailed description of very small changes in cell surface topography presents the basis on which the models of cell locomotion and the control of this event can be discussed appropriately. Cytosolic calcium controls force generation and the direction of locomotion. Ca2+ concentration is highest in the lamella/cell body transition region and at the leading front, as has been revealed by scanning fluorometry.
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Bereiter-Hahn, J., Braun, N., Vöth, M. (1990). Continuity of Movement and Preservation of Architecture during Cell Locomotion. In: Alt, W., Hoffmann, G. (eds) Biological Motion. Lecture Notes in Biomathematics, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51664-1_5
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DOI: https://doi.org/10.1007/978-3-642-51664-1_5
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