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Developmental and Molecular Regulation of Immunoglobulin Class Switch Recombination

  • Chapter
Molecular Analysis of DNA Rearrangements in the Immune System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 217))

Abstract

The ability of B lymphocytes to perform immunoglobulin (lg) class switch recombination depends largely on their differentiation stage. Pro-B cells, pre-B cells, and plasma cells do not switch at detectable levels. B cell receptor (BCR) cross linking, T cell help, and cytokines can drive the mature B cells into proliferation and differentiation and induce switch recombination. This recombination is targeted to distinct switch regions by cytokines through the induction of switch transcripts (Lorenz et al. 1995a, b). Cytokines also control the frequency of detectable, switched cells by regulating the amount of Ig secreted and the clone size of switched cells (for review, see Vercelli and Geha 1992; Coffman et al. 1993; Harriman et al. 1993; Lorenz and Radbruch 1996). Here, we focus on those molecules, which are involved in the regulation of class switching.

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  1. Institute for Genetics, Weyertal 121, 50931, Cologne, Germany

    Matthias Lorenz & Andreas Radbruch

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  1. Matthias Lorenz
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  1. Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    Rolf Jessberger

  2. Division of Molecular Oncology, Department of Pathology, Washington University School of Medicine, Campus Box 8118, 660 So. Euclid Ave., 63110, St. Louis, MO, USA

    Michael R. Lieber

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Lorenz, M., Radbruch, A. (1996). Developmental and Molecular Regulation of Immunoglobulin Class Switch Recombination. In: Jessberger, R., Lieber, M.R. (eds) Molecular Analysis of DNA Rearrangements in the Immune System. Current Topics in Microbiology and Immunology, vol 217. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50140-1_11

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