Skip to main content

The Changing Role of Population Genetics Theory

  • Conference paper
Frontiers in Mathematical Biology

Part of the book series: Lecture Notes in Biomathematics ((LNBM,volume 100))

Abstract

Theoretical population genetics is surely a most unusual subject. At times it appears to have little connection with the parent subject on which it must depend, namely observational and experimental genetics, living an almost inbred life of its own. It cannot claim a status analogous to that of theoretical physics to justify doing this: the latter subject depends on very precise observational data and very precise models, so that if at times it proceeds ahead of observational physics on its own, it is on the basis of quite firm foundations. Theoretical population genetics, on the other hand, rests on often vague and sometimes contradictory foundations and too inbred a development of the theory soon leads to irrelevancy. What should be the methods of progress in population genetics theory, and how should these methods change with changes in mainstream genetics?

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Dawkins, R. (1986). The Blind Watchmaker. Longman, Harlow.

    Google Scholar 

  • Dobzhansky, T. (1970). Genetics of the Evolutionary Process. Columbia University Press, New York.

    Google Scholar 

  • Ewens, W.J. (1989). An interpretation and proof of the fundamental theorem of natural selection. Theoret. Pop. Biol., 36, 167–180.

    Article  MathSciNet  MATH  Google Scholar 

  • Ewens, W.J. (1993). Beanbag genetics and after, pp 7–29 in “Human Population Genetics: A Centennial Tribute to J.B.S. Haldane,” edited by Partha P. Majumder. Plenum Press, New York.

    Google Scholar 

  • Feldman, M.W. (1972). Selection for linkage modification. 1. Random mating populations. Theoret. Pop. Biol., 3, 324–346.

    Article  Google Scholar 

  • Fisher, R.A. (1922). On the dominance ratio. Proc. Roy. Soc. Edin., 42, 321–341.

    Google Scholar 

  • Fisher, R.A. (1930). The Genetical Theory of Natural Selection. Clarendon Press, Oxford.

    MATH  Google Scholar 

  • Fisher, R.A. (1941). Average excess and average effect of a gene substitution. Ann. Eugen., 11, 53–63.

    Article  Google Scholar 

  • Fisher, R.A. (1958). The Genetical Theory of Natural Selection. Dover, New York.

    Google Scholar 

  • Haldane, J.B.S. (1964). A defense of beanbag genetics. Perspectives in Biology and Medicine, 7, 343–359.

    Google Scholar 

  • Hoyle, F. and Wickramasinghe, N. C. (1981). Evolution from Space., Dent, London.

    Google Scholar 

  • Kimura, M. (1955). Solution of a process of random genetic drift with a continuous model. Proc. Nat. Acad.. Sci., 41, 144–150.

    Article  MATH  Google Scholar 

  • Kimura, M. (1968). Evolutionary rates at the molecular level. Nature, 217, 624–626.

    Article  Google Scholar 

  • Kimura, M. and Ohta, T. A. (1971). On the rate of molecular evolution. J. Mol. Biol. 1, 1–17.

    Google Scholar 

  • Kingman, J. F. C. (1961). A mathematical problem in population genetics. Proc. Camb. Phil. Soc, 57, 574–582.

    Article  MathSciNet  MATH  Google Scholar 

  • Kingman, J. F.C. (1988). Typical polymorphisms maintained by natural selection. J. Appl. Prob., 25A, 113–125.

    Article  MathSciNet  Google Scholar 

  • Lovetrup, S. (1987). Darwinism: the Refutation of a Myth. Croon Helm, London.

    Google Scholar 

  • Mayr, E. (1963). Animal Species and Evolution. Harvard University Press, Cambridge MA.

    Google Scholar 

  • Nei, M. (1967). Modification of linkage intensity by natural selection. Genetics, 57, 625–641.

    MathSciNet  Google Scholar 

  • Norton, H.T.J. (1915). Appendix to Mimicry in Butterflies, by R.C. Punnett. Cambridge University Press, Cambridge.

    Google Scholar 

  • Price, G.R. (1972). Fisher Fundamental Theorem made clear. Ann. Hum. Genet., 36, 129–140.

    Article  Google Scholar 

  • Provine, W. (1986). Sewall Wright and Evolutionary Biology. University of Chicago Press, Chicago.

    Google Scholar 

  • Schoemaker, P.J.H. (1991). The quest for optimality: a positive heuristic of science? Behav. and Brain Sci., 14, 205–245.

    Article  Google Scholar 

  • Simpson, G.G. (1944). Tempo and Mode in Evolution. Columbia University Press, New York.

    Google Scholar 

  • Wright, S. (1930). The genetical theory of natural selection — a review. J. Hered., 21, 349–356.

    Google Scholar 

  • Wright, S. (1931). Evolution in Mendelian populations. Genetics, 16, 97–159.

    Google Scholar 

  • Wright, S. (1978). Evolution and the Genetics of Populations. Vol. 4. Variability within and among natural populations. University of Chicago Press, Chicago.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Ewens, W.J. (1994). The Changing Role of Population Genetics Theory. In: Levin, S.A. (eds) Frontiers in Mathematical Biology. Lecture Notes in Biomathematics, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50124-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-50124-1_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-50126-5

  • Online ISBN: 978-3-642-50124-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics