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Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating-Factor)

  • Chapter
Peptide Growth Factors and Their Receptors I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 1))

Abstract

The study of mononuclear phagocytes has been greatly aided by the purification, molecular cloning, and vector-mediated production of biologically active colony-stimulating factors that regulate the proliferation and support the viability of monocytes, macrophages, and their bone marrow progenitors. The term “colony stimulating factor” (CSF) was first applied to a group of impure growth factors obtained from tissues and biological fluids and from culture media conditioned by certain cell lines. These compounds were initially recognized through their ability to stimulate the formation of colonies composed of differentiated myeloid cells from single bone marrow-derived precursor cells plated in semisolid medium (Pluznix and Sachs 1965; Bradley and Metcalf 1966; Ichikawa et al. 1966). Colonies did not develop in the absence of such factors, and their patterns of differentiation were found to be governed by the source of CSF, suggesting that multiple growth factors were responsible for the types of colonies obtained (Ichixawa et al. 1966; Metcalf et al. 1967, 1974; Metcalf 1969).

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  1. C. J. Sherr
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  2. E. R. Stanley
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  1. Laboratory of Chemoprevention, National Cancer Institute, Bldg. 41, Room C-629, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

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Sherr, C.J., Stanley, E.R. (1990). Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating-Factor). In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Handbook of Experimental Pharmacology, vol 95 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49295-2_15

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