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Interleukin-5

  • Chapter
Peptide Growth Factors and Their Receptors I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 1))

Abstract

The immune response to a foreign antigen is regulated by a series of interactions between T lymphocytes (T cells), B lymphocytes (B cells), and macrophages. During this process B cells proliferate and mature into plasma cells which produce antibodies against distinct determinants of the antigen, and the antibodies produced play a key role in the humoral immune response. The B-cell response to an antigen is regulated by a helper T cell responding to, and specific for, the same antigen molecule. Helper T cells recognize antigens in the context of class II major histocompatibility complex (MHC) molecules on accessory cells and/or B cells, and secrete several soluble factors including interleukin-4 (IL-4) and IL-5 which can induce growth and maturation of B cells (reviewed by Howard and Paul 1983; Kishimoto 1985). IL-5 was initially described as a factor that induces terminal differentiation of B cells to immunoglobulin (Ig)-secreting cells, and originally designated as T-cell-replacing factor (TRF; Dutton and Swain 1987; Takatsu 1988; Dutton et al. 1971; Schimpl and Wecker 1972).

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  1. T. Honjo
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  2. K. Takatsu
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Editors and Affiliations

  1. Laboratory of Chemoprevention, National Cancer Institute, Bldg. 41, Room C-629, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

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Honjo, T., Takatsu, K. (1990). Interleukin-5. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Handbook of Experimental Pharmacology, vol 95 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49295-2_13

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  • DOI: https://doi.org/10.1007/978-3-642-49295-2_13

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