Zusammenfassung
Es wird ein Modell der intestinalen Darmkrypte dargestellt, das mit Hilfe eines Computersimulationsexperiments entwickelt wurde. Dieses Modell vereinigt zwei grundlegende Konzepte der Zellproliferations- und Differentiationskontrolle: erstens die Regulation der Proliferation (d.h. die Kontrolle darüber, ob sich eine teilungsfähige Zelle teilt oder nicht) und der Differentiation (d.h. die Funktion der Zelle) durch die zellintern repräsentierte Generationszahl. Zweitens die Regulation der Wiedertierstellung des stabilen Gleichgewichts des Zellverbandes nach einer Störung durch einen inhibitiven Kontrollmechanismus.
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Meinzer, H.P., Baur, H.J., Sandblad, B., Rodrigues, L. (1990). Mögliche Mechanismen zur Proliferations- und Differentiationskontrolle. In: Giani, G., Repges, R. (eds) Biometrie und Informatik — neue Wege zur Erkenntnisgewinnung in der Medizin. Medizinische Informatik und Statistik, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48167-3_26
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DOI: https://doi.org/10.1007/978-3-642-48167-3_26
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