Zusammenfassung
Kontrollierte klinische Studien sind die allgemein anerkannte wissenschaftliche Methode zum Wirksamkeitsnachweis von Therapien. In einer korrekt geplanten und durchgeführten Studie kann man aufgrund der zufälligen Zuteilung der Behandlungen davon ausgehen, daß der Therapievergleich in der betrachteten Studienpopulation als valide anzusehen ist, was wir als interne Validität bezeichnen. Die Konsequenzen, die eine Studie für die medizinische Praxis erhält, hängen jedoch stark von ihrer Verallgemeinerungsfähigkeit ab, was wir als externe Validität bezeichnen.
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Olschewski, M., Schumacher, M., Davis, K. (1990). Auswertung randomisierter und nicht-randomisierter Patienten in klinischen Studien. In: Giani, G., Repges, R. (eds) Biometrie und Informatik — neue Wege zur Erkenntnisgewinnung in der Medizin. Medizinische Informatik und Statistik, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48167-3_13
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