Skip to main content

Wertigkeit von CD-Transferrin in der Rückfalldiagnostik

  • Chapter
Klinische Alkoholismusdiagnostik
  • 71 Accesses

Zusammenfassung

Die therapeutische Bearbeitung von Rückfällen ist ein zentrales Element in der Entwöhnung von Alkoholabhängigen. Für den Arzt oder Therapeuten wären dabei Tests, mit deren Hilfe solche Rückfälle zuverlässig erkannt werden können, ein nützliches Instrument in der Langzeitbehandlung dieser Patienten. Vor allem in der Frühphase der Entwöhnung, die sich in der Regel an eine Entzugsbehandlung anschließt, könnte damit erneuter Alkoholkonsum erkannt und die vielfältigen in der Regel folgenden Komplikationen möglicherweise verhindert werden. Bestenfalls kann auf diese Weise das Vollbild eines Rückfalls mit kontrollverlustigem Trinken und das Wiedereinsetzen des kompletten Abhängigkeitssyndroms vermieden werden (8). Dazu können objektive Labortests geeignet sein, denn Patienten neigen immer wieder dazu, die Wiederaufnahme ihres Trinkens in Abstinenzorientierten Langzeitprogrammen zu bagatellisieren oder ganz zu verleugnen; außerdem sind Berichte von Bezugspersonen („significant others“) nicht immer einzuholen, mit denen der Patient konfrontiert werden kann.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 49.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Allen JP, Anton RF, Cross GM (1994) Carbohydrate-Deficient Transferrin as a measure of immoderate drinking: remaining issues. Alcohol Clin Exp Res 18:799–812

    Article  PubMed  CAS  Google Scholar 

  2. Anton RF, Moak DH (1994) Carbohydrate-deficient transferrrin and γ-Glutamyltransferase as markers of heavy alcohol consumption: gender differences. Alcohol Clin Exp Res 18:747–754

    Article  PubMed  CAS  Google Scholar 

  3. Behrens UJ, Worner TM, Lieber CS (1988) Changes in Carbohydrate-deficient transferrin levels after alcohol withdrawal. Alcohol Clin Exp Res 12:539–544

    Article  PubMed  CAS  Google Scholar 

  4. Bell H, Tallaksen CME, Try K, Haug E (1994) Carbohydrate-deficient transferrin and other markers of high alcohol consumption: a study of 502 patients admitted consecutively to a medical department. Alcohol Clin Exp Res 18:1103–1108

    Article  PubMed  CAS  Google Scholar 

  5. Borg S, Helander H, Carlsson AV, Högström Brandt AM (1995) Detection of relapses in alcohol-dependent patients using Carbohydrate-deficient Transferrin: improvement with individualized reference levels during long-term monitoring. Alcohol Clin Exp Res 19:961–963

    Article  PubMed  CAS  Google Scholar 

  6. Carlsson VA, Hiltunen AJ, Beck O, Stibler H, Borg S (1993) Detection of relapses in alcohol-dependent patients: comparisons of Carbohydrate-deficient transferrin in serum, 5-Hydroxy-tryptophol in urine and self-reports. Alcohol Clin Exp Res 17:703–708

    Article  PubMed  CAS  Google Scholar 

  7. Conigrave KM, Saunders JB, Whitfield JB (1995) Diagnostic tests for alcohol consumption. Alcohol Alcoholism 30:13–26

    CAS  Google Scholar 

  8. Irwin M, Baird S, Smith TL, Schuckit M (1988) Use of laboratory test to monitor heavy drinking by alcoholic men discharged from a treatment program. Am J Psychiatry 145:595–599

    PubMed  CAS  Google Scholar 

  9. Flechter RH (1988) Clinical Epidemiology. Williams & Wilkins, Baltimore

    Google Scholar 

  10. Groenbeck M, Henriksen JH, Becker U (1995) Carbohydrate-Deficient Transferrin — a valid marker of alcoholism in population studies? Results from the Copenhagen City Heart Study. Alcohol Clin Exp Res 1995:457–461

    Article  Google Scholar 

  11. Huseby NE, Bjordal E, Nilssen O, Barth T (1997) Utility of biological markers during outpatient treatment of alcohol-dependent subjects: Carbohydrate-Deficient Transferrin responds to moderate changes in alcohol consumption. Alcohol Clin Exp Res 21:1343–1346

    PubMed  CAS  Google Scholar 

  12. Kairisto V: GraphROC for windows. University of Turku, Department of Clinical Chemistry, Finland

    Google Scholar 

  13. Kapur A, Wild G, Milford-Ward A, Triger DR (1989) Carbohydrate-deficient transferrin: a marker for alcohol abuse. Br Med J 299:427–431

    Article  CAS  Google Scholar 

  14. Müller Ch, Bräutigam K, Moritz R, Rüggeberg J, Köttgen E (1993) A simplified test procedure for measuring carbohydrate-deficient transferrin in serum. Eur J Clin Chem Clin Biochem 9:A42

    Google Scholar 

  15. Mitchell C, Simpson D, Chick J (1997) Carbohydrate deficient transferrin in detecting relapse in alcohol dependence. Drug Alc Depend 48:97–103

    Article  CAS  Google Scholar 

  16. Rosman AS, Lieber CS (1994) Diagnostic utility of laboratory tests in alcoholic liver disease. Clin Chem 40/8:1641–1651

    PubMed  CAS  Google Scholar 

  17. Rosman AS, Basu P, Galvin K, Lieber CS (1995) Utility of Carbohydrate-Deficient Transferrin as a marker of relapse in alcoholic patients. Alcohol Clin Exp Res 19:611–616

    Article  PubMed  CAS  Google Scholar 

  18. Salmela KJ, Laitinen K, Nyström M, Salaspuro M (1994) Carbohydrate-deficient transferrin during 3 weeks’ heavy alcohol consumption. Alcohol Clin Exp Res 18:228–230

    Article  PubMed  CAS  Google Scholar 

  19. Schmidt LG, Schmidt K, Dufeu P, Ohse A, Rommelspacher H, Müller C (1997) Superiority of Carbohydrate-Deficient Transferrin to γ-Glutamyltransferase in detecting relapse in alcoholism. Am J Psychiat 154:75–80

    PubMed  CAS  Google Scholar 

  20. Shaw, LM, Stromme JH, London JL, Theodorson L (1983) IFCC-method for γ-glutamyltransferase. J Clin Chem Clin Biochem 21:633–646

    PubMed  CAS  Google Scholar 

  21. Stibler H (1991) Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption. Clin Chemistry 37:2029–2037

    CAS  Google Scholar 

  22. World Health Organization (1990) CIDI — The Composite International Diagnostic Interview. Core Version 1.0 Division of Mental Health, WHO, Geneva

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Steinkopff Verlag, Darmstadt

About this chapter

Cite this chapter

Schmidt, L.G. (1999). Wertigkeit von CD-Transferrin in der Rückfalldiagnostik. In: Soyka, M. (eds) Klinische Alkoholismusdiagnostik. Steinkopff. https://doi.org/10.1007/978-3-642-47709-6_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-47709-6_12

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-1193-4

  • Online ISBN: 978-3-642-47709-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics