Abstract
The lod score method for localizing mendelian disease genes in human genetics is reviewed. Current ways of applying this technique to hypothesized genes underlying complex traits are discussed. In contrast to these parametric methods, allele-sharing methods using affected sib pairs are reviewed. Based on such allele-sharing data, a particular type of analysis is outlined which can identify sets of disease loci. This method makes use of pattern-recognition techniques as implemented in artificial neural networks (ANNs).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bishop CM (1995) Neural networks for pattern recognition. Clarendon, Oxford
Claus EB, Risch N, Thompson WD (1991) Genetic analysis of breast cancer in the cancer and steroid hormone study. Am J Hum Genet 48: 232 - 242
Curtis D, Sham PC (1995) Model-free linkage analysis using likelihoods. Am J Hum Genet 57: 703 - 716
Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SCL, Jenkins SC, Palmer SM, Balfour KM, Rowe BR, Farrall M, Barnett AH, Bain SC, Todd JA (1994)A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371: 130 - 136
Hall JM, Lee MK, Morrow J, Newman B, Anderson L, Huey B, King MC (1990) Linkage analysis of early onset familial breast cancer to chromosome 17q21. Science 250: 1684 - 1689
Hashimoto L, Habita C, Beressi JP, Delepine M, Besse C, Cambon-Thomson A, Deschamps I, Rotter JI, Djoulah S, James MR, Froguel P, Weissenbach J, Lathrop GM, Julier C (1994) Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq. Nature 71: 161 - 164
Hugot J-P, Laurent-Puig P, Gower-Rousseau C, Olson JM, Lee JC, Beaugerie L, Naom I, Dupas J-L, Van Gossum A, Orholm M, Bonaiti-Pellie C, Weissenbach J, Mathew CG, Lennard-Jones JE, Cortot A, Colombel J-F, Thomas G (1996) Mapping of a susceptibility locus for Crohns disease on chromosome 16. Nature 379: 821 - 823
Kong A, Cox NJ (1997) Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61: 1179-1188
Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58: 1347 - 1363
Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature [Genet] 11: 241 - 247
Lange K, Weeks D, Boehnke M (1988) Programs for pedigree analysis: MENDEL, FISHER, and dGENE. Genet Epidemiol 5: 471-472
Lathrop GM, Lalouel JM, Julier C, Ott J (1984) Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81: 3443 - 3446
Mérette C, King M-C, Ott J (1992) Heterogeneity analysis of breast cancer families by using age at onset as a covariate. Am J Hum Genet 50: 515 - 519
Morton NE (1955) Sequential tests for the detection of linkage. Am J Hum Genet 7: 277 - 318
Ott J (1991) Analysis of human genetic linkage. Johns Hopkins University Press, Baltimore Ott J (1996) Complex traits on the map. Nature 379: 772 - 773
Risch N (1990) Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 46: 222 - 228
Risch N, Ghosh S, Todd JA (1993) Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus ( IDDM ). Am J Hum Genet 53: 702-714
Weeks DE, Lathrop GM (1995) Polygenic disease: methods for mapping complex disease traits. Trends Genet 11: 513 - 519
Weeks DE, Lehner T, Squires-Wheeler E, Kaufmann C, Ott J (1990) Measuring the inflation of the lod score due to its maximization over model parameter values in human linkage analysis. Genet Epidemiol 7: 237 - 243
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Ott, J., Lucek, P. (1998). Complex Traits on the Map. In: Schwab, M., Rabes, H.M., Munk, K., Hofschneider, H.P. (eds) Genes and Environment in Cancer. Recent Results in Cancer Research, vol 154. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46870-4_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-46870-4_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-46872-8
Online ISBN: 978-3-642-46870-4
eBook Packages: Springer Book Archive