Abstract
The fundamental role of deoxyribonucleotides as precursors in the cellular synthesis of DNA has prompted an extensive investigation of the biochemical processes involved in their formation. Tracer experiments performed in vivo have established that in Escherichia coli — as in several bacterial and animal cells — deoxyribonucleotides are synthesized exclusively by reduction of the corresponding ribonucleotides (cf. [1]). In vivo experiments have also demonstrated that in the cell the conversion of a ribosyl to a deoxyribosyl compound is an irreversible process.
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Larsson, A. (1969). Enzymatic Reduction of Ribonucleotides in Escherichia coli. In: Horecker, B.L., Lang, K., Takagi, Y. (eds) International Symposium on Metabolism, Physiology, and Clinical Use of Pentoses and Pentitols. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46191-0_4
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DOI: https://doi.org/10.1007/978-3-642-46191-0_4
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