Abstract
I am very pleased to have the opportunity to participate in this Symposium and to present the opening paper. Since this will serve as a general introduction to the discussions that follow, I will take the opportunity to indulge in some frank speculation regarding the evolutionary origin of the pathways of carbohydrate metabolism and the possible role of pentitols and other polyols. I have been interested in the metabolism of pentoses and polyols for some time and I believe that this is a good time to review the subject and to examine the present state of our knowledge with respect to the biochemistry and physiology of the pentoses and pentitols, as well as the general role of polyols in carbohydrate metabolism.
This work was supported by grants from the National Institutes of Health (GM 11301) and the National Sciences Foundation (GB 1465). This is communication No. 106 from the Joan and Lester Avnet Institute of Molecular Biology
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References
Hollmann, S., and O. Touster : An enzymatic pathway from L-xyluloseto D-xylulose. J. Amer. chem. Soc. 78, 3544 (1956).
Harden, A., and W. J. Young: The alcoholic ferment of yeast juice. Proc. roy. Soc. B 77, 405 (1906).
Meyerhof, O.: Über das Vorkommen des Coferments der alkoholischen Hefegärung im Muskelgewebe und seine mutmaßliche Bedeutung im Atmungsmechanismus. Hoppe-Seylers Z. physiol. Chem. 101, 165 (1918).
Warburg, O., W. Christian, A. Griese: Wasserstoff übertragendes Co-Ferment, seine Zusammensetzung und Wirkungsweise. Biochem. Z. 282, 157 (1935).
Warburg, O., W. Christian, Abbau von Robisonester durch Triphospho-Pyridin-Nucleotid. Biochem. Z. 292, 287 (1937).
Lipmann, F.: Fermentation of phosphogluconic acid. Nature (Lond.) 588 (1936)
Dickens, F.: CCXI. Oxidation of phosphohexonate and pentose phosphoric acids by yeast enzymes. I. Oxidation of phosphohexonate. II. Oxidation of pentose phosphoric acids. Biochem. J. 32, 1626 (1938).
Haas, E., B. L. Horecker, T. R. Hogness: The enzymatic reduction of cytochrome C. J. biol. Chem. 136, 747 (1940).
Horecker, B. L.: Triphosphopyridine nucleotide-cytochrome C reductase in liver. J. biol. Chem. 183, 593 (1950).
Lehninger, A., in: Phosphorus metabolism ( W. D. McElroy and B. Glass, editors), p. 344. Baltimore, Maryland: Johns Hopkins Press 1951.
Jacobson, K. B., N. O. Kaplan: Pyridine coenzymes of subcellular tissue fractions. J. biol. Chem. 226, 603 (1957).
Carson, P. E., C. L. Flanagan, C. E. Ickes, and A. L. Alving: Enzymatic deficiency in primaquine-sensitive erythrocytes. Science 124, 484 (1956).
13- Wald, G.: The origins of life. Proc. nat. Acad. Sei. (Wash.) 52, 595 (1964).
Englehardt, Y. A., and A. P. Barkash: Oxidative breakdown of phosphor-gluconic acid. Biokhimiya 3, 500 (1938).
Horecker, B. L., P. Z. Smyrniotis, and J. E. Seegmiller: The enzymatic conversion of 6-phosphogluconate to ribulose 5-phosphate and ribose 5-phosphate. J. biol. Chem. 193, 383 (1951).
Dische, Z.: Phosphorylierung der im Adenosin enthaltenen d-Ribose und nachfolgender Zerfall des Esters unter Triosephosphatbildung im Blute. Naturwissenschaften 26, 252 (1938).
Horecker, B. L., M. Gibbs, H. Klenow, and P. Z. Smyrniotis: The mechanism of pentose phosphate conversion to hexose monophosphate. I. With a liver enzyme preparation. J. biol. Chem. 207, 393 (1954).
Pontremoli, S., A. Bonsignore, E. Grazi, and B. L. Horecker: A coupled reaction catalyzed by the enzymes transketolase and transaldolase. J. biol. Chem. 235, 1881 (1960).
Katz, J., and H. G. Wood : The use of glucose-C14 for the evaluation of the Pathways of glucose metabolism. J. biol. Chem. 235, 2165 (I960).
Sowden, J. C., S. Frankel, B. H. Moore, and J. E. McClary: Utilization of 1-C14-D-glucose by Torula utilis yeast. J. biol. Chem. 206, 547 (1954).
Wood, H. G., P. Schambye, and E. J. Peeters: Lactose synthesis. II. The distribution of C14 in lactose of milk from the perfused isolated cow udder. J. biol. Chem. 226, 1023 (1957).
Feingold, D. S., E. F. Neufeld, and W. Z. Hassid: The 4-epimerization and decarboxylation of uridine diphosphate D-glucuronic acid by extracts from Phaseolus aureus seedlings. J. biol. Chem. 235, 940 (1960).
Oparin, I.: Life, its nature, origin and development. London: Oliver and Boyd 1961.
Berkner, L. V., L. C. Marshall: Discussions Faraday Soc. 122 (1964).
Morse, D. E., and B. L. Horecker : The mechanism of action of aldolases. Ad vane. Enzymol. 30 (in press).
De Moss, R. D.: Routes of ethanol formation in bacteria. J. cell. comp. Physiol. 41 (Suppl. 1), 207 (1953).
Hurwitz, J.: Pentose phosphate cleavage by Leuconostoc mesenteroides. Biochim. biophys. Acta (Amst.) 28, 599 (1958).
Eltz, R. W., and P. J. Yandermark: Fructose dissimilation in Lactobacillus brevis. J. Bact. 79, 763 (1967).
Martinez, G., H. A. Barker, B. L. Horecker: A specific mannitol dehydrogenase from Lactobacillus brevis. J. biol. Chem. 238, 1598 (1963).
Scher, B. M., and B. L. Horecker: Pentose metabolism in Candida. III. The TPN-specific polyol dehydrogenase of C. utilis. Arch. Biochem. 116, 117 (1966).
Hers, H. G.: Le metabolisme du fructose. Brussels: Arscia 1957
Szeinberg, A., and P. Marks: Substances stimulating glucose catabolism by the oxidative reactions of the pentose phosphate pathway in human erythrocytes. J. clin. Invest. 40, 914 (1961).
Kinoshita, J. H., S. Futterman, K. Satoh, and L. O. Merola: Factors affecting the formation of sugar alcohols in ocular lens. Biochim. biophys. Acta (Amst.) 74, 340 (1963).
Gabbay, K. H., L. O. Merola, and R. A. Field: Sorbitol pathway: Presence in nerve and cord with substrate accumulation in diabetes. Science 151, 209 (1966).
Kinoshita, J. H.: The stimulation of the phosphogluconate oxidation pathway by pyruvate in bovine corneal epithelium. J. biol. Chem. 228, 247 (1957).
Dische, Z., E. Borenfreund, and G. Zelmenis: Changes in lens proteins of rats during aging. Arch. Ophthal. 55, 471 (1956).
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Horecker, B.L. (1969). The Role of Pentitols and other Polyols in Evolutionary Development. In: Horecker, B.L., Lang, K., Takagi, Y. (eds) International Symposium on Metabolism, Physiology, and Clinical Use of Pentoses and Pentitols. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46191-0_2
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